scholarly journals Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats

2013 ◽  
Vol 9 (4) ◽  
pp. 406-412 ◽  
Author(s):  
Chang-Youl Park ◽  
Shin-Ho Lee ◽  
Bo-Kyun Kim ◽  
Mal-Soon Shin ◽  
Chang-Ju Kim ◽  
...  
Keyword(s):  
Brain Injury ◽  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability ◽  
Neonatal Rats ◽  
Hypoxic Ischemia

scholarly journals Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats

2017 ◽  
Vol 13 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Jun-Jang Jin ◽  
Il-Gyu Ko ◽  
Sung-Eun Kim ◽  
Lakkyong Hwang ◽  
Man-Gyoon Lee ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability ◽  
Adult Age ◽  
Age Dependent

scholarly journals Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy

2021 ◽  
Vol 17 (2) ◽  
pp. 88-95
Author(s):  
Tae-Woon Kim ◽  
Young Jun Ko ◽  
Ki-Hyok Youn ◽  
Boo-Geun Hwang ◽  
Hyun-Seok Bang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability

scholarly journals Asiatic acid exerts neuroprotective effect against hypoxicischemic brain injury in neonatal rats via inhibition of oxidative damage

2021 ◽  
Vol 20 (9) ◽  
pp. 1903-1908
Author(s):  
Ying Wang ◽  
Huiping Wang ◽  
Pu Zhao ◽  
Jiwen Cheng ◽  
Wei Gong ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Brain ◽  
Caspase 3 ◽  
Brain Cortex ◽  
Neonatal Rat ◽  
Asiatic Acid ◽  
Neonatal Rats ◽  
Expression Levels ◽  
Rat Brain Cortex ◽  
Hypoxic Ischemia

Purpose: To investigate the effect of asiatic acid on hypoxic ischemia-induced injury in neonatal rats, and the underlying mechanism of action.Methods: Hypoxic-ischemia (HI) neonatal rat model was established via permanent ligation of the carotid artery, followed by hypoxia (exposure to 8 % oxygen and 92 % nitrogen) for 24 h. Immunofluorescence, using fluorescence microscope, was used for the determination of expressions of p-TAK1, NeuN and GFAP. Western blotting was used for assaying protein expression levels, while TUNEL assay was employed for the measurement of apoptosis.Results: Treatment of rats with asiatic acid prior to HI effectively prevented up-regulation of pTAK1 and decreased the count of p-TAK1-containing astrocytes. The proportion of NeuN containing p-TAK1 in HI rat brain cortex was significantly reduced by asiatic acid (p < 0.05). Treatment of rats with asiatic acid suppressed HI- induced up-regulation of pJNK expression. The HI-induced increase in the expression levels of caspase-3, p53 and p-c-Jun in rat brain cortex were reversed by asiatic acid (p < 0.05). The HImediated up-regulation of expressions of p- JNK, caspase-3, p53 and p-c-Jun in rat brain cortex were inhibited significantly by NG25. Asiatic acid treatment also significantly alleviated HI-mediated increase in apoptosis of neurons in rat brain cortex, when compared to model group (p < 0.05).Conclusion: These findings suggest that asiatic acid prevents HI-induced brain injury in neonatal rats via inhibition of neuronal apoptosis. Moreover, it inhibits TAK1 activation, suppresses p-JNK expression and targets pro-apoptotic factors in brain cortex. Therefore, asiatic acid may be a therapeutic agent for the management of HI-induced brain injury.

scholarly journals Treadmill exercise ameliorates disturbance of spatial learning ability in scopolamine-induced amnesia rats

2014 ◽  
Vol 10 (3) ◽  
pp. 155-161 ◽  
Author(s):  
Yu-Mi Heo ◽  
Mal-Soon Shin ◽  
Su-Hyun Kim ◽  
Tae-Wook Kim ◽  
Sang-Bin Baek ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability

scholarly journals Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats

2015 ◽  
Vol 11 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Eun-Sang Ji ◽  
You-Mi Kim ◽  
Mal-Soon Shin ◽  
Chang-Ju Kim ◽  
Kwang-Sik Lee ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability ◽  
Hippocampal Apoptosis
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