scholarly journals Acupoint Stimulation Using Bee Venom Attenuates Formalin-Induced Pain Behavior and Spinal Cord Fos Expression in Rats

2003 ◽  
Vol 65 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Hyun-Woo KIM ◽  
Young-Bae KWON ◽  
Tae-Won HAM ◽  
Dae-Hyun ROH ◽  
Seo-Yeon YOON ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Pain Behavior ◽  
Bee Venom ◽  
Fos Expression ◽  
Acupoint Stimulation

scholarly journals Neuronal Activity Stimulated by Liquid Substrates Injection at Zusanli (ST36) Acupoint: The Possible Mechanism ofAquapuncture

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chun-Yen Chen ◽  
Chao-Nan Lin ◽  
Rey-Shyong Chern ◽  
Yu-Chuan Tsai ◽  
Yung-Hsien Chang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuronal Activity ◽  
Spatial Configuration ◽  
The Other ◽  
Bee Venom ◽  
Neuronal Signaling ◽  
Fos Protein ◽  
Configuration Changes ◽  
Acupoint Stimulation ◽  
Stimulation Of

Aquapunctureis a modified acupuncture technique and it is generally accepted that it has a greater therapeutic effect than acupuncture because of the combination of the acupoint stimulation and the pharmacological effect of the drugs. However, to date, the mechanisms underlying the effects ofaquapunctureremain unclear. We hypothesized that both the change in the local spatial configuration and the substrate stimulation ofaquapuncturewould activate neuronal signaling. Thus, bee venom, normal saline, and vitamins B1 and B12 were injected into a Zusanli (ST36) acupoint as substrate ofaquapuncture, whereas a dry needle was inserted into ST36 as a control. Afteraquapuncture, activated neurons expressing Fos protein were mainly observed in the dorsal horn of the spinal cord in lumbar segments L3–5, with the distribution nearly identical among all groups. However, the bee venom injection induced significantly more Fos-expressing neurons than the other substrates. Based on these data, we suggest that changes in the spatial configuration of the acupoint activate neuronal signaling and that bee venom may further strengthen this neuronal activity. In conclusion, the mechanisms for the effects ofaquapunctureappear to be the spatial configuration changes occurring within the acupoint and the ability of injected substrates to stimulate neuronal activity.

Intrathecal CGRP 8-37 attenuates formalin-induced pain behavior and spinal cord fos expression in rats

2011 ◽  
Vol 44 (13) ◽  
pp. S67
Author(s):  
Takhshid Mohammad Ali ◽  
Owji Ali Akbar ◽  
Khoshdel Zahra
Keyword(s):  
Spinal Cord ◽  
Pain Behavior ◽  
Fos Expression

The effect of stimulus duration on noxious-stimulus induced c-fos expression in the rodent spinal cord

1992 ◽  
Vol 580 (1-2) ◽  
pp. 172-179 ◽  
Author(s):  
Elizabeth Bullitt ◽  
Chong Lam Lee ◽  
Alan R. Light ◽  
Helen Willcockson
Keyword(s):  
Spinal Cord ◽  
Stimulus Duration ◽  
Noxious Stimulus ◽  
Fos Expression

Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin

1995 ◽  
Vol 272 (2-3) ◽  
pp. 249-259 ◽  
Author(s):  
Prisca Honoré ◽  
Jaroslava Buritova ◽  
Jean-Marie Besson
Keyword(s):  
Spinal Cord ◽  
Lumbar Spinal Cord ◽  
Fos Expression ◽  
Lumbar Spinal

c-Fos expression in rat spinal cord induced by scorpion BmK venom via plantar subcutaneous injection

2002 ◽  
Vol 44 (4) ◽  
pp. 447-454 ◽  
Author(s):  
Zhan-Tao Bai ◽  
Bing Chen ◽  
Xu-Ying Zhang ◽  
Guang-Li Fan ◽  
Yong-Hua Ji
Keyword(s):  
Spinal Cord ◽  
Subcutaneous Injection ◽  
Rat Spinal Cord ◽  
Fos Expression

c-Fos expression in the spinal cord after acute sacral segmental nerve stimulation

2002 ◽  
Vol 21 (5) ◽  
pp. 495-501 ◽  
Author(s):  
Manabu Ishigooka ◽  
Teruhiro Nakada ◽  
Tohru Hashimoto ◽  
Dirk-Henrik Zermann ◽  
Richard A. Schmidt
Keyword(s):  
Spinal Cord ◽  
Nerve Stimulation ◽  
Segmental Nerve ◽  
Fos Expression

The Effect of a Thoracic Spinal Block on Fos Expression in the Lumbar Spinal Cord of the Rat Induced by a Noxious Electrical Stimulus at the Hindpaw

2009 ◽  
Vol 109 (5) ◽  
pp. 1659-1665
Author(s):  
Janneke L. P. Giele ◽  
Anneke F. Nabers ◽  
Jan G. Veening ◽  
Jan van Egmond ◽  
Kris C. P. Vissers
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulus ◽  
Lumbar Spinal Cord ◽  
Spinal Block ◽  
Thoracic Spinal ◽  
Fos Expression ◽  
Lumbar Spinal

Role of NMDA and AMPA glutamatergic transmission in spinal c-fos expression after urinary tract irritation

1996 ◽  
Vol 270 (5) ◽  
pp. R990-R996 ◽  
Author(s):  
H. Kakizaki ◽  
M. Yoshiyama ◽  
W. C. de Groat
Keyword(s):  
Spinal Cord ◽  
Urinary Tract ◽  
Nmda Antagonist ◽  
Early Gene ◽  
Mk 801 ◽  
Sacral Parasympathetic Nucleus ◽  
Fos Expression ◽  
Dose Dependent Decrease ◽  
Nociceptive Input

Chemical irritation of the lower urinary tract (LUT) of the rat increases the expression of the immediate early gene c-fos within neurons in the dorsal horn (DH), dorsal commissure (DCM), and intermediolateral region, including sacral parasympathetic nucleus (SPN) of the spinal cord (L6-S1). A previous study indicated the involvement of the N-methyl-D-aspartic acid (NMDA) receptor in this c-fos expression after LUT irritation. The role of glutamatergic synapses was further investigated using a selective and competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor antagonist (LY-215490). Systemic administration of LY-215490 produced a dose-dependent decrease in the number of Fos-positive cells after LUT irritation in the DCM and SPN areas, whereas in the DH only the highest dose (10 mg/kg) of LY-215490 decreased the number of Fos-positive cells. A low dose (1 mg/kg) of either MK-801 (an NMDA antagonist) or LY-215490 alone did not alter c-fos expression. However, a combined administration of low doses of MK-801 and LY-215490 significantly decreased the number of Fos-positive cells in all regions of the spinal cord. These results indicate that AMPA as well as NMDA receptors are involved in the spinal processing of nociceptive input from the LUT and that these glutamatergic receptors play a synergistic role in visceral nociceptive processing.

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