c-Fos expression in the spinal cord after acute sacral segmental nerve stimulation

2002 ◽  
Vol 21 (5) ◽  
pp. 495-501 ◽  
Author(s):  
Manabu Ishigooka ◽  
Teruhiro Nakada ◽  
Tohru Hashimoto ◽  
Dirk-Henrik Zermann ◽  
Richard A. Schmidt
Keyword(s):  
Spinal Cord ◽  
Nerve Stimulation ◽  
Segmental Nerve ◽  
Fos Expression

The effect of stimulus duration on noxious-stimulus induced c-fos expression in the rodent spinal cord

1992 ◽  
Vol 580 (1-2) ◽  
pp. 172-179 ◽  
Author(s):  
Elizabeth Bullitt ◽  
Chong Lam Lee ◽  
Alan R. Light ◽  
Helen Willcockson
Keyword(s):  
Spinal Cord ◽  
Stimulus Duration ◽  
Noxious Stimulus ◽  
Fos Expression

Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin

1995 ◽  
Vol 272 (2-3) ◽  
pp. 249-259 ◽  
Author(s):  
Prisca Honoré ◽  
Jaroslava Buritova ◽  
Jean-Marie Besson
Keyword(s):  
Spinal Cord ◽  
Lumbar Spinal Cord ◽  
Fos Expression ◽  
Lumbar Spinal

scholarly journals Percutaneous peripheral nerve stimulation for treatment of shoulder pain after spinal cord injury: A case report

2017 ◽  
Vol 41 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Daniela Mehech ◽  
Melvin Mejia ◽  
Gregory A. Nemunaitis ◽  
John Chae ◽  
Richard D. Wilson
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Peripheral Nerve ◽  
Shoulder Pain ◽  
Nerve Stimulation ◽  
Peripheral Nerve Stimulation ◽  
Cord Injury

c-Fos expression in rat spinal cord induced by scorpion BmK venom via plantar subcutaneous injection

2002 ◽  
Vol 44 (4) ◽  
pp. 447-454 ◽  
Author(s):  
Zhan-Tao Bai ◽  
Bing Chen ◽  
Xu-Ying Zhang ◽  
Guang-Li Fan ◽  
Yong-Hua Ji
Keyword(s):  
Spinal Cord ◽  
Subcutaneous Injection ◽  
Rat Spinal Cord ◽  
Fos Expression

scholarly journals Cutaneous inputs from perineal region facilitates and modulates spinal locomotor activity and reduces cutaneous reflexes from the foot in spinal cats

2020 ◽  
Author(s):  
Angèle N Merlet ◽  
Jonathan Harnie ◽  
Madalina Macovei ◽  
Adam Doelman ◽  
Nathaly Gaudreault ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nerve Stimulation ◽  
Rhythmic Activity ◽  
Short Latency ◽  
Cutaneous Reflexes ◽  
Excitatory Effect ◽  
Reflex Responses ◽  
Cutaneous Reflex ◽  
Weight Support ◽  
Perineal Region

AbstractIt is well known that mechanically stimulating the perineal region potently facilitates hindlimb locomotion and weight support in mammals with a spinal transection (spinal mammals). However, how perineal stimulation mediates this excitatory effect is poorly understood. We evaluated the effect of mechanically stimulating (vibration or pinch) the perineal region on ipsilateral (9-14 ms onset) and contralateral (14-18 ms onset) short-latency cutaneous reflex responses evoked by electrically stimulating the superficial peroneal or distal tibial nerve in seven adult spinal cats where hindlimb movement was restrained. Cutaneous reflexes were evoked before, during, and after mechanical stimulation of the perineal region. We found that vibration or pinch of the perineal region effectively triggered rhythmic activity, unilateral and bilateral to nerve stimulation. When electrically stimulating nerves, adding perineal stimulation modulated rhythmic activity by decreasing cycle and burst durations and by increasing the amplitude of flexors and extensors. Perineal stimulation also disrupted the timing of the ipsilateral rhythm, which had been entrained by nerve stimulation. Mechanically stimulating the perineal region decreased ipsilateral and contralateral short-latency reflex responses evoked by cutaneous inputs, a phenomenon we observed in muscles crossing different joints and located in different limbs. The results suggest that the excitatory effect of perineal stimulation on locomotion and weight support is not mediated by increasing cutaneous reflex gain and instead points to an excitation of central pattern-generating circuitry. Our results are consistent with a state-dependent modulation of reflexes by spinal interneuronal circuits.Significance StatementMechanically stimulating the skin of the perineal region strongly facilitates hindlimb locomotion in mammals following a complete spinal cord injury (SCI). Despite its remarkable effectiveness in promoting hindlimb locomotion in spinal cord-injured mammals, we do not know how this is mediated. The present study provides data on how inputs from the perineal region interact with neuronal circuits that generate locomotor-like activity and reflexes from the foot. A better understanding of how inputs from the perineal region interact with neuronal circuits of the spinal cord could lead to non-invasive approaches to restore walking in people with SCI.

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