scholarly journals Dynamic Computer Tomography Is Useful in the Differential Diagnosis of Juxtaglomerular Cell Tumor and Renal Cell Carcinoma.

2001 ◽  
Vol 24 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Akiyo TANABE ◽  
Mitsuhide NARUSE ◽  
Tetsuya OGAWA ◽  
Fumio ITO ◽  
Sachiko TAKAGI ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Computer Tomography ◽  
Renal Cell ◽  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

773: C-KIT and CK7 Immunohistochemistry in the Differential Diagnosis of Renal Cell Carcinoma, A Study of 111 Cases

2004 ◽  
Vol 171 (4S) ◽  
pp. 205-205
Author(s):  
Jonathan J. Ord ◽  
David Cranston ◽  
Adrian L. Harris ◽  
Leticia Campo ◽  
Helen Turley ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Renal Cell

scholarly journals Differential Diagnosis of Renal Tumors With Clear Cytoplasm: Clinical Relevance of Renal Tumor Subclassification in the Era of Targeted Therapies and Personalized Medicine

2013 ◽  
Vol 137 (4) ◽  
pp. 467-480 ◽  
Author(s):  
Rajen Goyal ◽  
Elizabeth Gersbach ◽  
Ximing J. Yang ◽  
Stephen M. Rohan
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Clear Cell ◽  
Renal Tumor ◽  
Renal Tumors ◽  
Cell Renal Cell Carcinoma ◽  
Immunohistochemical Stains

Context.—The World Health Organization classification of renal tumors synthesizes morphologic, immunohistochemical, and molecular findings to define more than 40 tumor types. Of these, clear cell (conventional) renal cell carcinoma is the most common malignant tumor in adults and—with the exception of some rare tumors—the most deadly. The diagnosis of clear cell renal cell carcinoma on morphologic grounds alone is generally straightforward, but challenging cases are not infrequent. A misdiagnosis of clear cell renal cell carcinoma has clinical consequences, particularly in the current era of targeted therapies. Objective.—To highlight morphologic mimics of clear cell renal cell carcinoma and provide strategies to help differentiate clear cell renal cell carcinoma from other renal tumors and lesions. The role of the pathologist in guiding treatment for renal malignancies will be emphasized to stress the importance of proper tumor classification in patient management. Data Sources.—Published literature and personal experience. Conclusions.—In challenging cases, submission of additional tissue is often an inexpensive and effective way to facilitate a correct diagnosis. If immunohistochemical stains are to be used, it is best to use a panel of markers, as no one marker is specific for a given renal tumor subtype. Selection of limited markers, based on a specific differential diagnosis, can be as useful as a large panel in reaching a definitive diagnosis. For renal tumors, both the presence and absence of immunoreactivity and the pattern of labeling (membranous, cytoplasmic, diffuse, focal) are important when interpreting the results of immunohistochemical stains.

scholarly journals Dual role of KRT17: development of papillary renal cell tumor and progression of conventional renal cell carcinoma

2019 ◽  
Vol 10 (21) ◽  
pp. 5124-5129 ◽  
Author(s):  
Donat Peter Sarlos ◽  
Maria V Yusenko ◽  
Lehel Peterfi ◽  
Arpad Szanto ◽  
Gyula Kovacs
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Dual Role ◽  
Cell Tumor ◽  
Conventional Renal Cell Carcinoma

scholarly journals Renal Tumors in Young Adults: Is Preoperative Computer Tomography Imaging Suggestive for the Nature of the Tumors?

Diagnostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 380
Author(s):  
Andreea Zaharie ◽  
Sorana D. Bolboacă ◽  
Tudor Moisoiu ◽  
Dan Burghelea ◽  
Gheorghita Iacob ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Young Adults ◽  
Cell Carcinoma ◽  
Computer Tomography ◽  
Renal Cell ◽  
Clear Cell ◽  
Renal Tumors ◽  
Tomography Imaging ◽  
Computer Tomography Imaging

Renal cell carcinoma (RCC) accounts for 2–3% of all adult malignant neoplasms and is even rarer in patients under 45 years old. Clear-cell carcinoma represents most of the pathological subtypes. Our study aimed to investigate the association between preoperative computer tomography imagistic evaluation and histopathological diagnosis of renal tumors in young adults. Patients younger than 45 years old with renal tumors who were referred for medical treatment at the Clinical Institute of Urology and Renal Transplantation Cluj-Napoca from 2012 to 2019 were considered eligible for the study. Medical charts were retrospectively reviewed, and patients with complete data regarding preoperative diagnostic, histopathological evaluation, and follow-up data, regardless of gender, were included in the study. Sixteen patients younger than 45 years fulfilled all the inclusion criteria and were evaluated. With two exceptions, the evaluated patients were in a T1 and T2 stage, with no vascular invasion or of the adjacent organs. Two-thirds of our patients had a clear-cell renal cell carcinoma. None of our patients fitted in the low complexity surgery category of the R.E.N.A.L. Nephrometry Score and 37.5% of them benefited from partial nephrectomy. Half of the suppositions made based on imaging were concordant with the histopathology report. Fifteen of the patients showed no recurrence during the respective follow-up interval. Computer tomography imaging reports showed on our sample a higher concordance with the histopathological report in the more common subtypes (namely Renal Clear Cell RCC), with typical appearances.

scholarly journals Synchronous mixed germ cell tumor of testis and renal cell carcinoma: A rare presentation

2019 ◽  
Vol 60 ◽  
pp. 123-125
Author(s):  
Satish Deshmukh ◽  
Sushrut Fulare ◽  
Sanjeev Chowksey ◽  
Angir Soitkar ◽  
Akshay Nagre ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Germ Cell ◽  
Cell Carcinoma ◽  
Germ Cell Tumor ◽  
Renal Cell ◽  
Cell Tumor ◽  
Rare Presentation ◽  
Mixed Germ Cell Tumor

scholarly journals High-Grade Carcinomas Involving the Renal Sinus: Report of a Case and Review of the Differential Diagnosis and Immunohistochemical Expression

2012 ◽  
Vol 136 (8) ◽  
pp. 907-910 ◽  
Author(s):  
Allison Young ◽  
Lakshmi P. Kunju
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Collecting Duct ◽  
Upper Urinary Tract ◽  
High Grade ◽  
Renal Sinus

We report the case of a high-grade carcinoma involving the kidney in a young male with renal vein thrombosis and review the differential diagnosis and immunohistochemical workup. High-grade neoplasms involving the renal sinus include collecting duct carcinomas (CDCs), renal medullary carcinomas (RMCs), invasive high-grade urothelial carcinoma (UC) of the upper urinary tract, clear cell renal cell carcinoma, and type 2 papillary renal cell carcinoma. Distinguishing UC from CDC and RMC is problematic in small biopsy samples. The diagnosis of CDC (a rare, aggressive subtype of renal cell carcinoma) is challenging and requires the exclusion of UC. Renal medullary carcinoma is characterized by an appropriate clinical setting and consistent loss of nuclear expression of integrase interactor 1 (INI-1). A panel consisting of p63, paired box gene 8 (PAX8), and INI-1 is most optimal in distinguishing UC from CDC and RMC. A subset of urothelial carcinoma of upper urinary tract may be positive with PAX8.

scholarly journals Nonfunctioning Juxtaglomerular Cell Tumor

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ryoko Sakata ◽  
Hiroaki Shimoyamada ◽  
Masahiro Yanagisawa ◽  
Takayuki Murakami ◽  
Kazuhide Makiyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Preoperative Diagnosis ◽  
Renal Tumor ◽  
Cell Tumor ◽  
Renal Tumors ◽  
Biological Behavior ◽  
Middle Portion ◽  
Younger Patients ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare. Here, we report a case of nonfunctioning JGCT in a 31-year-old woman. The patient presented with a left renal tumor without hypertension or hypokalemia. Under a clinical diagnosis of renal cell carcinoma, radical nephrectomy was performed. The tumor was located in the middle portion adjacent to the renal pelvis, measuring 2 cm in size. Pathologically, the tumor was composed of cuboidal cells forming a solid arrangement, immunohistochemically positive for renin. Based on these findings, the tumor was diagnosed as JGCT. In cases with hyperreninism, preoperative diagnosis of JGCT is straightforward but difficult in nonfunctioning case. Generally, JGCT presents a benign biological behavior. Therefore, we should take nonfunctioning JGCT into the differential diagnoses for renal tumors, especially in younger patients to avoid excessive surgery.

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