scholarly journals Nonfunctioning Juxtaglomerular Cell Tumor

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ryoko Sakata ◽  
Hiroaki Shimoyamada ◽  
Masahiro Yanagisawa ◽  
Takayuki Murakami ◽  
Kazuhide Makiyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Preoperative Diagnosis ◽  
Renal Tumor ◽  
Cell Tumor ◽  
Renal Tumors ◽  
Biological Behavior ◽  
Middle Portion ◽  
Younger Patients ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare. Here, we report a case of nonfunctioning JGCT in a 31-year-old woman. The patient presented with a left renal tumor without hypertension or hypokalemia. Under a clinical diagnosis of renal cell carcinoma, radical nephrectomy was performed. The tumor was located in the middle portion adjacent to the renal pelvis, measuring 2 cm in size. Pathologically, the tumor was composed of cuboidal cells forming a solid arrangement, immunohistochemically positive for renin. Based on these findings, the tumor was diagnosed as JGCT. In cases with hyperreninism, preoperative diagnosis of JGCT is straightforward but difficult in nonfunctioning case. Generally, JGCT presents a benign biological behavior. Therefore, we should take nonfunctioning JGCT into the differential diagnoses for renal tumors, especially in younger patients to avoid excessive surgery.

scholarly journals Juxtaglomerular cell tumor diagnosed preoperatively by renal tumor biopsy

2021 ◽  
Author(s):  
Takashi Ueda ◽  
Yukiko Morinaga ◽  
Kai Inoue ◽  
Sojiro Hirano ◽  
Hiroki Matsubara ◽  
...  
Keyword(s):  
Renal Tumor ◽  
Cell Tumor ◽  
Tumor Biopsy ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

scholarly journals Dynamic Computer Tomography Is Useful in the Differential Diagnosis of Juxtaglomerular Cell Tumor and Renal Cell Carcinoma.

2001 ◽  
Vol 24 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Akiyo TANABE ◽  
Mitsuhide NARUSE ◽  
Tetsuya OGAWA ◽  
Fumio ITO ◽  
Sachiko TAKAGI ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Computer Tomography ◽  
Renal Cell ◽  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

Juxtaglomerular Cell Tumor With Atypical Pathological Features: Report of a Case and Review of Literature

2019 ◽  
Vol 28 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Ashley Hagiya ◽  
Ming Zhou ◽  
Andrew Hung ◽  
Manju Aron
Keyword(s):  
Lymphovascular Invasion ◽  
Renal Tumor ◽  
Clinical Course ◽  
Cell Tumor ◽  
Pathological Features ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor ◽  
Mitotic Figures

Juxtaglomerular cell tumor (JGCT) is a rare renal tumor with a predominantly benign clinical course. It affects young adults, who often present with hypertension, hypokalemia, and hyperaldosteronism. The tumor cells are round to spindle-shaped with occasional mild to moderate atypia, but mitotic figures are usually absent. Surgical resection is the treatment of choice. Typically, the blood pressure and renin levels normalize after removal of the tumor. Rare cases of metastatic and recurrent JGCT have been reported including cases with vascular invasion. These cases typically occur in older adults and present with larger tumor size (9-15 cm). We report a case of JGCT, 5.5 cm in greatest dimension, with atypical pathological features including invasion of the renal vein, lymphovascular invasion, and significant pleomorphism with rhabdoid morphology, along with a brief review of the literature.

Juxtaglomerular Cell Tumor of Kidney With CD34 and CD117 Immunoreactivity: Report of 5 Cases

2006 ◽  
Vol 130 (5) ◽  
pp. 707-711 ◽  
Author(s):  
Hyun-Jung Kim ◽  
Chul Hwan Kim ◽  
Yeong-Jin Choi ◽  
Alberto G. Ayala ◽  
Mojgan Amirikachi ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Smooth Muscle Actin ◽  
Cell Tumor ◽  
Renal Tumors ◽  
Renal Neoplasm ◽  
Electron Microscopic ◽  
Primary Methods ◽  
Juxtaglomerular Cell ◽  
Eosinophilic Cytoplasm ◽  
Juxtaglomerular Cell Tumor

Abstract Context.—Juxtaglomerular cell tumor is a rare renal neoplasm. Renin immunohistochemistry and electron microscopic documentation of rhomboid crystals are the primary methods of diagnosing this benign tumor. Objectives.—In this retrospective study, we evaluated the morphologic, immunohistochemical, and ultrastructural features of 5 cases of juxtaglomerular cell tumor to determine the effectiveness of CD34 and CD117 immunohistochemistry for the diagnosis of this tumor. Design.—We reviewed 5 cases with clinical, histologic, immunohistochemical, and ultrastructural aspects. Results.—Three women and 2 men with a mean age of 37.8 years (range, 16–60 years) were included in this study. All patients presented with severe hypertension. All tumors were well circumscribed and ranged from 1.5 cm to 8.5 cm (mean, 4.4 cm). On light microscopic examination, we found solid sheets and nests of tumor cells with oval-to-round nuclei and eosinophilic cytoplasm. Low-power microscopic examination disclosed a hemangiopericytic vascular pattern. Immunohistochemistry results were as follows: vimentin (positive), renin (weakly positive), smooth muscle actin (focal immunoreactivity), and cytokeratin (negative). All 5 tumors were immunoreactive for CD34 and CD117. Electron microscopy revealed rhomboid crystals in the cytoplasm. Postoperatively, 4 patients were normotensive and 1 patient experienced persistent mild hypertension. Conclusions.—Our findings indicate that immunohistochemistry for CD34 and CD117 are effective at diagnosing juxtaglomerular cell tumor. Juxtaglomerular cell tumor should be considered in the diagnosis of any renal tumors with epithelioid cells and negative initial cytokeratin immunohistochemistry.

Metastatic Juxtaglomerular Cell Tumor in a 52-Year-Old Man

2004 ◽  
Vol 28 (8) ◽  
pp. 1098-1102 ◽  
Author(s):  
Xiuzhen Duan ◽  
Patrick Bruneval ◽  
Rasheed Hammadeh ◽  
Raoul Fresco ◽  
John N Eble ◽  
...  
Keyword(s):  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

Juxtaglomerular Cell Tumor of the Kidney

2020 ◽  
pp. 164-165
Author(s):  
Anna Caliò ◽  
Diego Segala ◽  
Guido Martignoni
Keyword(s):  
Cell Tumor ◽  
Juxtaglomerular Cell ◽  
Juxtaglomerular Cell Tumor

scholarly journals Differential Diagnosis of Renal Tumors With Clear Cytoplasm: Clinical Relevance of Renal Tumor Subclassification in the Era of Targeted Therapies and Personalized Medicine

2013 ◽  
Vol 137 (4) ◽  
pp. 467-480 ◽  
Author(s):  
Rajen Goyal ◽  
Elizabeth Gersbach ◽  
Ximing J. Yang ◽  
Stephen M. Rohan
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell ◽  
Clear Cell ◽  
Renal Tumor ◽  
Renal Tumors ◽  
Cell Renal Cell Carcinoma ◽  
Immunohistochemical Stains

Context.—The World Health Organization classification of renal tumors synthesizes morphologic, immunohistochemical, and molecular findings to define more than 40 tumor types. Of these, clear cell (conventional) renal cell carcinoma is the most common malignant tumor in adults and—with the exception of some rare tumors—the most deadly. The diagnosis of clear cell renal cell carcinoma on morphologic grounds alone is generally straightforward, but challenging cases are not infrequent. A misdiagnosis of clear cell renal cell carcinoma has clinical consequences, particularly in the current era of targeted therapies. Objective.—To highlight morphologic mimics of clear cell renal cell carcinoma and provide strategies to help differentiate clear cell renal cell carcinoma from other renal tumors and lesions. The role of the pathologist in guiding treatment for renal malignancies will be emphasized to stress the importance of proper tumor classification in patient management. Data Sources.—Published literature and personal experience. Conclusions.—In challenging cases, submission of additional tissue is often an inexpensive and effective way to facilitate a correct diagnosis. If immunohistochemical stains are to be used, it is best to use a panel of markers, as no one marker is specific for a given renal tumor subtype. Selection of limited markers, based on a specific differential diagnosis, can be as useful as a large panel in reaching a definitive diagnosis. For renal tumors, both the presence and absence of immunoreactivity and the pattern of labeling (membranous, cytoplasmic, diffuse, focal) are important when interpreting the results of immunohistochemical stains.

Claudin-7 Immunohistochemistry in Renal Tumors: A Candidate Marker for Chromophobe Renal Cell Carcinoma Identified by Gene Expression Profiling

2007 ◽  
Vol 131 (10) ◽  
pp. 1541-1546 ◽  
Author(s):  
Christopher D. Hornsby ◽  
Cynthia Cohen ◽  
Mahul B. Amin ◽  
Maria M. Picken ◽  
Diane Lawson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Clear Cell ◽  
Renal Tumor ◽  
Renal Tumors ◽  
Tumor Subtypes ◽  
Chromophobe Rcc ◽  
Clear Cell Rccs ◽  
Expression Marker

Abstract Context.—The differential diagnosis of eosinophilic renal tumors can be difficult by light microscopy. In particular, chromophobe renal cell carcinoma (RCC) is difficult to distinguish from oncocytoma. This differential diagnosis is important because chromophobe RCC is malignant, whereas oncocytoma is benign. Furthermore, chromophobe RCC has distinct malignant potential and prognosis compared with eosinophilic variants of other RCC subtypes. Immunohistochemistry is useful for distinguishing chromophobe RCC from other subtypes of renal carcinoma, but no expression marker reliably separates chromophobe RCC from oncocytoma. Objective.—In a previous gene expression microarray analysis of renal tumor subtypes, we found the distal nephron markers claudin-7 and claudin-8 to be overexpressed in chromophobe RCC versus oncocytoma and other tumor subtypes. We have confirmed similar findings in independent microarray data and validated differential claudin-7 protein expression by immunohistochemistry. Design.—Immunohistochemical analysis of claudin-7 in 36 chromophobe RCCs, 43 oncocytomas, 42 clear cell RCCs, and 29 papillary RCCs. Results.—Membranous claudin-7 expression was detected in 67% chromophobe RCCs, compared with 0% clear cell RCCs, 28% papillary RCCs, and 26% oncocytomas (P < .001). Conclusions.—Based on microarray and immunohistochemical data, we propose claudin-7 to be a candidate expression marker for distinguishing chromophobe RCC from other renal tumor subtypes, including the morphologically similar oncocytoma. The clinical utility of claudin-7 should be validated in independent studies of renal tumors, possibly in combination with additional targets in a multiplex immunohistochemical panel.

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