scholarly journals Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults

2018 ◽  
Vol 126 (1) ◽  
pp. 017005 ◽  
Author(s):  
Fen Wu ◽  
Liang Chi ◽  
Hongyu Ru ◽  
Faruque Parvez ◽  
Vesna Slavkovich ◽  
...  
Keyword(s):  
Drinking Water ◽  
Arsenic Exposure

Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water

2018 ◽  
Vol 234 ◽  
pp. 590-600 ◽  
Author(s):  
Xiaoyan Du ◽  
Meiping Tian ◽  
Xiaoxue Wang ◽  
Jie Zhang ◽  
Qingyu Huang ◽  
...  
Keyword(s):  
Drinking Water ◽  
Arsenic Exposure

ANALYSIS OF ABDOMINAL TYPHOID INCIDENCE IN THE SOUTH REGION OF THE KYRGYZ REPUBLIC

2020 ◽  
pp. 43-48
Author(s):  
Zakirova J.S. ◽  
Nadirbekova R.A. ◽  
Zholdoshev S.T.
Keyword(s):  
Drinking Water ◽  
Typhoid Fever ◽  
Risk Groups ◽  
The Body ◽  
Kyrgyz Republic ◽  
Radiation Factor ◽  
High Quality ◽  
Two Generations ◽  
Immunological Deficiency

The article analyze the long-term morbidity, spread of typhoid fever in the southern regions of the Kyrgyz republic, and remains a permanent epidemic focus in the Jalal-Abad region, where against the low availability of the population to high-quality drinking water, an additional factor on the body for more than two generations and radiation factor, which we confirmed by the spread among the inhabitants of Mailuu-Suu of nosological forms of the syndrome of immunological deficiency, as a predictor of risk groups for infectious diseases, including typhoid fever.

In pursuit of sustainable water solutions in emerging regions

2013 ◽  
Vol 3 (4) ◽  
pp. 489-499 ◽  
Author(s):  
Laura R. Brunson ◽  
Lowell W. Busenitz ◽  
David A. Sabatini ◽  
Paul Spicer
Keyword(s):  
Drinking Water ◽  
Technology Development ◽  
Market Development ◽  
Safe Drinking Water ◽  
Water Solutions ◽  
Enabling Environment ◽  
Cultural Assessment

While lack of access to consistent safe drinking water is estimated to affect nearly 2 billion people worldwide, many of the efforts to solve this crisis have proven to be unsustainable. This paper discusses some of the reasons for these challenges and suggests interdisciplinary practices that could be integrated from the very beginning of a water intervention to achieve long-term success. Of key importance for sustainable water implementation is an enabling environment that incorporates aspects such as funding, potential for market development, and supportive governance. While this enabling environment is acknowledged, the focus of this work is on the integration of three key areas: (i) social and cultural assessment of behavior and preferences; (ii) market-based implementation approaches that draw on this knowledge; and (iii) technology development for these markets.

scholarly journals Persistent, mobile and toxic (PMT) and very persistent and very mobile (vPvM) substances pose an equivalent level of concern to persistent, bioaccumulative and toxic (PBT) and very persistent and very bioaccumulative (vPvB) substances under REACH

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Sarah E. Hale ◽  
Hans Peter H. Arp ◽  
Ivo Schliebner ◽  
Michael Neumann
Keyword(s):  
Drinking Water ◽  
Human Health ◽  
Regulatory Decision ◽  
Drinking Water Resources ◽  
Trade Name ◽  
Chemicals Regulation ◽  
Range Transport ◽  
High Concern ◽  
Level Of Concern

Abstract Background Under the EU chemicals regulation REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals EC 1907/2006), registrants are not obliged to provide information related to intrinsic substance properties for substances that pose a threat to the drinking water resources. In 2019, perfluorobutane sulfonic acid (PFBS) and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoic acid (HFPO-DA trade name GenX) were demonstrated to have an equivalent level of concern (ELoC) to persistent, bioaccumulative and toxic or very persistent and very bioaccumulative (PBT/vPvB) substances owing to their persistent, mobile and toxic (PMT) substance properties and very persistent and very mobile (vPvM) substance properties, respectively. They were both subsequently identified as substances of very high concern (SVHC) applying Article 57(f) in REACH. This work follows up on this regulatory decision by presenting a science based, conceptual level comparison that all PMT/vPvM substances pose an ELoC to PBT/vPvB substances. Using the two cases named above, as well as 1,4-dioxane, 16 categories were developed to evaluate a) serious effects on human health, b) serious effects on the environment and c) additional effects. 1,4-dioxane has recently been proposed to be classified as Carcinogenic 1B by the Committee for Risk Assessment (RAC). The aim was to enable an objective and scientifically justified conclusion that these classes of substances have an equivalent level of concern for the environment and human health. Results In all of the categories related to human health, the environment and other effects, the PMT/vPvM case study substances exhibited comparable effects to PBT/vPvB substances. A difference in the human and environmental exposure pathways of PMT/vPvM and PBT/vPvB substances exists as they vary temporally and spatially. However, effects and impacts are similar, with PMT/vPvM substances potentially accumulating in (semi-)closed drinking water cycles and pristine aquatic environments, and PBT/vPvB substances accumulating in humans and the food chain. Both PMT/vPvM and PBT/vPvB substances share the common difficulty that long term and long-range transport and risk of exposure is very difficult to determine in advance and with sufficient accuracy. Conclusion The registration process of substances under REACH should reflect that PMT/vPvM substances pose an equivalent level of concern to PBT/vPvB substances.

scholarly journals Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06409
Author(s):  
Afsaneh Amiri ◽  
Yaser Mokhayeri ◽  
Rasool Mohammadi ◽  
Mohammad Amin Karami ◽  
Mansour Ghaderpoori ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Meta Analysis ◽  
Arsenic Exposure

scholarly journals Drinking Water Arsenic and Adverse Reproductive Outcomes in Men and Women: A Systematic PRISMA Review

Water ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 1885
Author(s):  
Ida M. Barsøe ◽  
Ninna H. Ebdrup ◽  
Hannah S. Clausen ◽  
Julie Lyngsø ◽  
Jörg Schullehner ◽  
...  
Keyword(s):  
Drinking Water ◽  
Spontaneous Abortion ◽  
Semen Quality ◽  
Arsenic Exposure ◽  
Quality Characteristics ◽  
Reproductive Outcomes ◽  
Case Control Studies ◽  
Time To Pregnancy ◽  
Cross Sectional ◽  
Men And Women

Infertility is a worldwide health issue, but mechanisms of both male and female reproductive toxicity remain to be elucidated. So far, a limited focus has been on potentially harmful environmental factors such as arsenic, which is naturally occurring in groundwater. The objective of this review was to systematically investigate the association between arsenic in drinking water and adverse reproductive outcomes in men and women of fertile age. We conducted a systematic literature search and included case-control studies and cohort studies reporting on decreased semen quality characteristics, increased time to pregnancy, infertility, or spontaneous abortion. In total, 433 articles were screened and ultimately, eight studies were included. Included literature was quality assessed with the Newcastle-Ottawa Scale. Findings were reported in a narrative synthesis. Only one study investigated male fertility. An association between increasing arsenic exposure and decreasing semen quality characteristics was found, as well as an indication of arsenic accumulation in seminal plasma. These findings are, however, at high arsenic levels (>1000 µg/L). No consistent evidence was found to support the hypothesis that arsenic exposure from drinking water is a cause of longer waiting time to pregnancy or spontaneous abortion, being the only endpoints investigated in the included literature. In conclusion; the evidence is sparse and of varying quality, however, it does warrant attention, as it conflicts with existing evidence, mainly from cross-sectional or ecologic studies.

scholarly journals Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Claudia Leticia Moreno Ávila ◽  
Jorge H. Limón-Pacheco ◽  
Magda Giordano ◽  
Verónica M. Rodríguez
Keyword(s):  
Drinking Water ◽  
Locomotor Activity ◽  
Dopamine Receptor ◽  
Dopaminergic System ◽  
Arsenic Exposure ◽  
D2 Receptors ◽  
Motor Memory ◽  
Arsenic Toxicity ◽  
D2 Dopamine Receptor ◽  
Cd1 Mice

Arsenic exposure has been associated with sensory, motor, memory, and learning alterations in humans and alterations in locomotor activity, behavioral tasks, and neurotransmitters systems in rodents. In this study, CD1 mice were exposed to 0.5 or 5.0 mg As/L of drinking water for 6 months. Locomotor activity, aggression, interspecific behavior and physical appearance, monoamines levels, and expression of the messenger for dopamine receptors D1 and D2 were assessed. Arsenic exposure produced hypoactivity at six months and other behaviors such as rearing and on-wall rearing and barbering showed both increases and decreases. No alterations on aggressive behavior or monoamines levels in striatum or frontal cortex were observed. A significant decrease in the expression of mRNA for D2 receptors was found in striatum of mice exposed to 5.0 mg As/L. This study provides evidence for the use of dopamine receptor D2 as potential target of arsenic toxicity in the dopaminergic system.

scholarly journals Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study

2011 ◽  
Vol 40 (3) ◽  
pp. 828-835 ◽  
Author(s):  
Y. Chen ◽  
F. Parvez ◽  
M. Liu ◽  
G. R. Pesola ◽  
M. V. Gamble ◽  
...  
Keyword(s):  
Drinking Water ◽  
Longitudinal Study ◽  
Health Effects ◽  
Arsenic Exposure

scholarly journals Design of an Epidemiologic Study of Drinking Water Arsenic Exposure and Skin and Bladder Cancer Risk in a U.S. Population

1998 ◽  
Vol 106 ◽  
pp. 1047 ◽  
Author(s):  
Margaret R. Karagas ◽  
Tor D. Tosteson ◽  
Joel Blum ◽  
J. Steven Morris ◽  
John A. Baron ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Arsenic Exposure ◽  
Epidemiologic Study ◽  
Bladder Cancer Risk
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