scholarly journals Design of an Epidemiologic Study of Drinking Water Arsenic Exposure and Skin and Bladder Cancer Risk in a U.S. Population

1998 ◽  
Vol 106 ◽  
pp. 1047 ◽  
Author(s):  
Margaret R. Karagas ◽  
Tor D. Tosteson ◽  
Joel Blum ◽  
J. Steven Morris ◽  
John A. Baron ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Arsenic Exposure ◽  
Epidemiologic Study ◽  
Bladder Cancer Risk

scholarly journals Design of an epidemiologic study of drinking water arsenic exposure and skin and bladder cancer risk in a U.S. population.

1998 ◽  
Vol 106 (suppl 4) ◽  
pp. 1047-1050 ◽  
Author(s):  
M R Karagas ◽  
T D Tosteson ◽  
J Blum ◽  
J S Morris ◽  
J A Baron ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Arsenic Exposure ◽  
Epidemiologic Study ◽  
Bladder Cancer Risk

056-S: Lifetime Exposure to Arsenic in Drinking Water and Bladder Cancer Risk in Michigan

2005 ◽  
Vol 161 (Supplement_1) ◽  
pp. S14-S14
Author(s):  
J R Meliker ◽  
M J Slotnick ◽  
G A AvRuskin ◽  
S A Fedewa ◽  
D Schottenfeld ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Bladder Cancer Risk ◽  
Lifetime Exposure

Low-level arsenic exposure is associated with bladder cancer risk and cigarette smoking: a case–control study among men in Tunisia

2012 ◽  
Vol 20 (6) ◽  
pp. 3923-3931 ◽  
Author(s):  
Molka Feki-Tounsi ◽  
Pablo Olmedo ◽  
Fernando Gil ◽  
Rim Khlifi ◽  
Mohamed-Nabil Mhiri ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Arsenic Exposure ◽  
Case Control ◽  
Bladder Cancer Risk ◽  
Low Level ◽  
Control Study

Nitrate in drinking water and bladder cancer risk in Spain

2015 ◽  
Vol 137 ◽  
pp. 299-307 ◽  
Author(s):  
Nadia Espejo-Herrera ◽  
Kenneth P. Cantor ◽  
Nuria Malats ◽  
Debra T. Silverman ◽  
Adonina Tardón ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Bladder Cancer Risk

scholarly journals Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor

2022 ◽  
Vol 2022 ◽  
pp. 1-26
Author(s):  
Sonalika Singhal ◽  
Nathan A. Ruprecht ◽  
Donald Sens ◽  
Kouhyar Tavakolian ◽  
Kevin L. Gardner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Bladder Cancer ◽  
Cancer Risk ◽  
Prediction Model ◽  
Differentially Expressed Genes ◽  
Expression Profiles ◽  
Arsenic Exposure ◽  
Gene Expression Profiles ◽  
Bladder Cancer Risk

The IARC classified arsenic (As) as “carcinogenic to humans.” Despite the health consequences of arsenic exposure, there is no molecular signature available yet that can predict when exposure may lead to the development of disease. To understand the molecular processes underlying arsenic exposure and the risk of disease development, this study investigated the functional relationship between high arsenic exposure and disease risk using gene expression derived from human exposure. In this study, a three step analysis was employed: (1) the gene expression profiles obtained from two diverse arsenic-exposed Asian populations were utilized to identify differentially expressed genes associated with arsenic exposure in human subjects, (2) the gene expression profiles induced by arsenic exposure in four different myeloma cancer cell lines were used to define common genes and pathways altered by arsenic exposure, and (3) the genetic profiles of two publicly available human bladder cancer studies were used to test the significance of the common association of genes, identified in step 1 and step 2, to develop and validate a predictive model of primary bladder cancer risk associated with arsenic exposure. Our analysis shows that arsenic exposure to humans is mainly associated with organismal injury and abnormalities, immunological disease, inflammatory disease, gastrointestinal disease, and increased rates of a wide variety of cancers. In addition, arsenic exerts its toxicity by generating reactive oxygen species (ROS) and increasing ROS production causing the imbalance that leads to cell and tissue damage (oxidative stress). Oxidative stress activates inflammatory pathways leading to transformation of a normal cell to tumor cell specifically; there is significant evidence of the advancing changes in oxidative/nitrative stress during the progression of bladder cancer. Therefore, we examined the relation of differentially expressed genes due to exposure of arsenic in human and bladder cancer and developed a bladder cancer risk prediction model. In this study, integrin-linked kinase (ILK) was one of the most significant pathways identified between both arsenic exposed population which plays a key role in eliciting a protective response to oxidative damage in epidermal cells. On the other hand, several studies showed that arsenic trioxide (ATO) is useful for anticancer therapy although the mechanisms underlying its paradoxical effects are still not well understood. ATO has shown remarkable efficacy for the treatment of multiple myeloma; therefore, it will be helpful to understand the underlying cancer biology by which ATO exerts its inhibitory effect on the myeloma cells. Our study found that MAPK is one of the most active network between arsenic gene and ATO cell line which is involved in indicative of oxidative/nitrosative damage and well associated with the development of bladder cancer. The study identified a unique set of 147 genes associated with arsenic exposure and linked to molecular mechanisms of cancer. The risk prediction model shows the highest prediction ability for recurrent bladder tumors based on a very small subset (NKIRAS2, AKTIP, and HLA-DQA1) of the 147 genes resulting in AUC of 0.94 (95% CI: 0.744-0.995) and 0.75 (95% CI: 0.343-0.933) on training and validation data, respectively.

scholarly journals DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk☆

2009 ◽  
Vol 187 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Angeline S. Andrew ◽  
Rebecca A. Mason ◽  
Karl T. Kelsey ◽  
Alan R. Schned ◽  
Carmen J. Marsit ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Arsenic Exposure ◽  
Bladder Cancer Risk

LINE-1 methylation, lifetime trihalomethane exposure from drinking water and bladder cancer risk

2013 ◽  
Vol 2013 (1) ◽  
pp. 4189
Author(s):  
Lucas A. Salas ◽  
Cristina M. Villanueva ◽  
Salman M. Tajuddin ◽  
André F. S. Amaral ◽  
Agustín F. Fernandez ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Bladder Cancer Risk

131-S: Drinking Water and Toenail Arsenic Concentrations as Predictors of Bladder Cancer Risk

2005 ◽  
Vol 161 (Supplement_1) ◽  
pp. S33-S33
Author(s):  
M J Slotnick ◽  
J R Meliker ◽  
G A AvRuskin ◽  
D Schottenfeld ◽  
J O Nriagu
Keyword(s):  
Bladder Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Bladder Cancer Risk

856: Dietary Carotenoids and Genetic Instability Modify Bladder Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 233-233
Author(s):  
Xifeng Wu ◽  
H. Barton Grossman ◽  
George L. Delclos ◽  
Ladia M. Hernandez ◽  
R. Sue Day ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Genetic Instability ◽  
Bladder Cancer Risk

Low vitamin D is associated with increased bladder cancer risk; a systematic review and evidence of a potential mechanism

2016 ◽  
Author(s):  
Rosemary Bland ◽  
Corina Chivu ◽  
Kieran Jefferson ◽  
Donald MacDonald ◽  
Gulnaz Iqbal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Bladder Cancer ◽  
Cancer Risk ◽  
Potential Mechanism ◽  
Bladder Cancer Risk
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