scholarly journals Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and National Toxicology Program (1976-1991).

1991 ◽  
Vol 96 ◽  
pp. 23-31 ◽  
Author(s):  
J Huff ◽  
J Haseman
Keyword(s):  
National Cancer Institute ◽  
Human Cancer ◽  
Chemical Carcinogenesis ◽  
National Toxicology Program

scholarly journals Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4240
Author(s):  
Manar M. Arafeh ◽  
Ebrahim Saeedian Moghadam ◽  
Sirin A. I. Adham ◽  
Raphael Stoll ◽  
Raid J. Abdel-Jalil
Keyword(s):  
Melting Point ◽  
Cytotoxic Activity ◽  
Elemental Analysis ◽  
13C Nmr ◽  
National Cancer Institute ◽  
Polyphosphoric Acid ◽  
Human Cancer ◽  
Indole Derivatives ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using 1H NMR, 13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 µM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.

Structure Activity Relationships of Antiproliferative Rocaglamide Derivatives from Aglaia Species (Meliaceae)

1999 ◽  
Vol 54 (1-2) ◽  
pp. 55-60 ◽  
Author(s):  
Frank I. Bohnenstengel ◽  
Klaus G. Steube ◽  
Corinna Meyer ◽  
Bambang W. Nugroho ◽  
Pham D. Hung ◽  
...  
Keyword(s):  
Cell Lines ◽  
Potential Role ◽  
Human Cancer ◽  
Experimental Medicine ◽  
Dependent Manner ◽  
Pyran Ring ◽  
Human Cancer Cell Lines ◽  
Structure Activity ◽  
High Doses

Eleven rocaglamide derivatives (cyclopentatetrahydrobenzofurans) and one structurally related aglain congener all isolated from different Aglaia species (Meliaceae) were tested for growth inhibiting properties using the human cancer cell lines MONO-MAC-6 and MEL-JUSO. Proliferation of both cell lines was efficiently inhibited in a dose and compound dependent manner. Applying a MTT-Assay, the IC50 of the most active compound didesmethyl-rocaglamide (1) was observed at 0.002 and 0.006 μg/ml (0.004 and 0.013 μM) depending on the cell line investigated. Bulky aminoacyl substituents at C-2, acetylation of the OH substituent at C-1 or insertion of a OH or OMe substituent at C-3 ’of the rocaglamide skeleton all diminished the activity of the compounds investigated. The aglain derivative 12 was inactive up to a concentration of 3 μg/ml (4.6 μᴍ) . This loss of activity is assumed to be mainly due to the presence of a pyran ring in the aglains vs. a furan ring as found in rocaglamide derivatives. Rocaglamide derivatives may act primarily by inhibition of cell proliferation as evidenced by the absence of a significant cytotoxic effect in long-term cultures of MONO-MAC-6 cells treated with high doses of didesmethylrocaglamide. Our data suggest that rocaglamide derivatives could exert a potential role in the treatment of malignant diseases and are worth to be investigated in further studies of experimental medicine and pharmacology

scholarly journals A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent

2020 ◽  
Vol 50 (6) ◽  
pp. 474-490 ◽  
Author(s):  
David A. Jett ◽  
Christopher A. Sibrizzi ◽  
Robyn B. Blain ◽  
Pamela A. Hartman ◽  
Pamela J. Lein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nerve Agent ◽  
Acute Exposure ◽  
Long Term Effects ◽  
National Toxicology Program

scholarly journals A Possible Relationship Between Toxicity and Carcinogenicity

1986 ◽  
Vol 5 (2) ◽  
pp. 137-151 ◽  
Author(s):  
L. Zeise ◽  
E. A.C. Crouch ◽  
R. Wilson
Keyword(s):  
Acute Toxicity ◽  
National Cancer Institute ◽  
Chronic Toxicity ◽  
Positive Finding ◽  
National Toxicology Program ◽  
Technical Report Series ◽  
Technical Report ◽  
Highly Correlated ◽  
Relationship Of ◽  
The Relationship

Carcinogenic response is compared to noncarcinogenic toxicity in that group of chemicals tested by the National Cancer Institute (NCI) and National Toxicology Program (NTP) between 1976 and 1982 and reported in the Carcinogenesis Technical Report Series. A positive finding of carcinogenicity in the bioassay is correlated with the degree of noncarcinogenic chronic toxicity of the dose applied. Comparisons of acute toxicity (LD50) with carcinogenic potency show that they are correlated, but the correlation may in part be an artifact, since doses used in the NCI/NTP carcinogenesis bioassays are toxic and because reliable measures of potency can only be derived for positive carcinogenic responses. The high correlations for certain classes of chemicals and the relationship of chronic toxicity to positive carcinogenic finding suggest that these relationships are more than spurious. Since toxicities in different species are highly correlated, these findings imply that carcinogenicities in different species are also correlated.

Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

2018 ◽  
Author(s):  
Friederike I. Nollmann ◽  
Patricia Perez Galan ◽  
Javier Garcia Fernandez ◽  
Heidi K. Walter ◽  
Johannes P. Magnusson ◽  
...  
Keyword(s):  
Nude Mice ◽  
Human Cancer ◽  
Albumin Binding ◽  
Xenograft Models ◽  
Complete Tumor
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