scholarly journals Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4240
Author(s):  
Manar M. Arafeh ◽  
Ebrahim Saeedian Moghadam ◽  
Sirin A. I. Adham ◽  
Raphael Stoll ◽  
Raid J. Abdel-Jalil
Keyword(s):  
Melting Point ◽  
Cytotoxic Activity ◽  
Elemental Analysis ◽  
13C Nmr ◽  
National Cancer Institute ◽  
Polyphosphoric Acid ◽  
Human Cancer ◽  
Indole Derivatives ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using 1H NMR, 13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 µM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.

Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines

2013 ◽  
Vol 6 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Justin T. Fischedick ◽  
Milica Pesic ◽  
Ana Podolski-Renic ◽  
Jasna Bankovic ◽  
Ric C.H. de Vos ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Sesquiterpene Lactones ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Inula Britannica

Diterpenoids from Leaves of Cultivated Plectranthus ornatus

Planta Medica ◽  
2020 ◽  
Author(s):  
Lidivânia Silva Freitas Mesquita ◽  
Taynara Simão Matos ◽  
Fábio do Nascimento Ávila ◽  
Alison da Silva Batista ◽  
Andréa Felinto Moura ◽  
...  
Keyword(s):  
Guinea Pig ◽  
13C Nmr ◽  
Intestinal Motility ◽  
Spectroscopic Analysis ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Guinea Pig Ileum ◽  
Atomic Orbitals ◽  
Human Cancer Cell Lines ◽  
Hct 116

AbstractTwo new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3–13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.

Cytotoxic Activity of Flavonoids and Extracts from Retama sphaerocarpa Boissier

2000 ◽  
Vol 55 (1-2) ◽  
pp. 40-43 ◽  
Author(s):  
Miguel López-Lázaro ◽  
Carmen Martín-Cordero ◽  
Felipe Cortés ◽  
Joaquín Piñero ◽  
María Jesús Ayuso
Keyword(s):  
Ethyl Acetate ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Srb Assay ◽  
Retama Sphaerocarpa ◽  
Human Cancer Cell Lines ◽  
Aerial Parts ◽  
Dependent Inhibition

Abstract Seven flavonoids isolated from chloroform , ethyl acetate and butanol extracts, obtained from the aerial parts of Retama sphaerocarpa, have been assessed for cytotoxic activity against three human cancer cell lines: TK-10 (renal adenocarcinom a), MCF-7 (breast adenocarcinom a) and UACC-62 (m elanom a), using the SRB assay. All of them , extracts and flavonoids, were actives in, at least, one of the three cell lines at the recom m ended N ational C ancer Institute doses. They produce a d ose-dependent inhibition of cell grow th at concentrations in the 10-6-10-4 ᴍ and 25 -250 μg/ml range for the flavonoids and extracts respectively, being the flavonol rhamnazin the most cytotoxic.

scholarly journals Alkaloids From Zanthoxylum nitidum and Their Cytotoxic Activity

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984413
Author(s):  
Thi Hong Van Nguyen ◽  
Thi Tuyen Tran ◽  
Thi Inh Cam ◽  
Minh Quan Pham ◽  
Quoc Long Pham ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Spectroscopy Data ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Zanthoxylum Nitidum ◽  
Mcf 7

Zanthoxylum nitidum (Roxb.) DC (Rutaceae) is a traditional medicine used for the treatment of various diseases like toothache, gingivitis, fever, colic vomiting, diarrhea, and cholera. Three new alkaloids, zanthocadinanine C (1), 7-methoxy-8-demethoxynitidine (2), and zanthonitiside I (3) were isolated from the stems and twigs of Z. nitidum. Their structures were determined on the basis of extensive spectroscopic, including 1-dimensional and 2-dimensional nuclear magnetic resonance and mass spectroscopy data. Compounds 1–3 were evaluated for cytotoxic activity against 5 human cancer cell lines, KB, MCF-7, LNCaP, HepG-2, and LU-1. Compound 2 showed significant cytotoxic activity against all tested human cancer cell lines with IC50 values ranging from 10.3 to 12.6 µM.

Synthesis, crystal structure, and cytotoxic activity of novel cyclic systems in [1,2,4]thiadiazolo[2,3-a]pyridine benzamide derivatives and their copper(ii) complexes

2014 ◽  
Vol 43 (21) ◽  
pp. 7945-7957 ◽  
Author(s):  
Forogh Adhami ◽  
Maliheh Safavi ◽  
Maryam Ehsani ◽  
Sussan K. Ardestani ◽  
Franziska Emmerling ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Planar Structure ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Square Planar ◽  
Benzamide Derivatives

Novel Cu2+complexes with a square planar structure synthesized from benzamide derivatives showed cytotoxic activity against different human cancer cell lines.

Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines

2004 ◽  
Vol 203 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Krzysztof Polkowski ◽  
Joanna Popiołkiewicz ◽  
Piotr Krzeczyński ◽  
Jan Ramza ◽  
Wiesław Pucko ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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