scholarly journals Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute.

1982 ◽  
Vol 45 ◽  
pp. 129-133 ◽  
Author(s):  
W M Kluwe ◽  
E E McConnell ◽  
J E Huff ◽  
J K Haseman ◽  
J F Douglas ◽  
...  
Keyword(s):  
National Cancer Institute ◽  
Phthalate Esters ◽  
National Toxicology Program ◽  
Related Compounds

scholarly journals A Possible Relationship Between Toxicity and Carcinogenicity

1986 ◽  
Vol 5 (2) ◽  
pp. 137-151 ◽  
Author(s):  
L. Zeise ◽  
E. A.C. Crouch ◽  
R. Wilson
Keyword(s):  
Acute Toxicity ◽  
National Cancer Institute ◽  
Chronic Toxicity ◽  
Positive Finding ◽  
National Toxicology Program ◽  
Technical Report Series ◽  
Technical Report ◽  
Highly Correlated ◽  
Relationship Of ◽  
The Relationship

Carcinogenic response is compared to noncarcinogenic toxicity in that group of chemicals tested by the National Cancer Institute (NCI) and National Toxicology Program (NTP) between 1976 and 1982 and reported in the Carcinogenesis Technical Report Series. A positive finding of carcinogenicity in the bioassay is correlated with the degree of noncarcinogenic chronic toxicity of the dose applied. Comparisons of acute toxicity (LD50) with carcinogenic potency show that they are correlated, but the correlation may in part be an artifact, since doses used in the NCI/NTP carcinogenesis bioassays are toxic and because reliable measures of potency can only be derived for positive carcinogenic responses. The high correlations for certain classes of chemicals and the relationship of chronic toxicity to positive carcinogenic finding suggest that these relationships are more than spurious. Since toxicities in different species are highly correlated, these findings imply that carcinogenicities in different species are also correlated.

scholarly journals Spontaneous Tumors of the Meninges in Rats

1987 ◽  
Vol 24 (1) ◽  
pp. 50-58 ◽  
Author(s):  
K. Mitsumori ◽  
R. R. Maronpot ◽  
G. A. Boorman
Keyword(s):  
National Cancer Institute ◽  
Spindle Cell ◽  
Granular Cell ◽  
Granular Cells ◽  
Spontaneous Tumors ◽  
National Toxicology Program ◽  
Anatomic Location ◽  
Arachnoid Cell

Histologic brain sections from 107 rats reported to have granular cell tumors or meningiomas in 2-year carcinogenicity studies conducted by the National Toxicology Program (NTP) or the National Cancer Institute (NCI) were reexamined microscopically. There were 62 rats with granular cell tumors, 26 with benign meningiomas, and 19 with meningeal sarcomas. Granular cell tumors were compatible with previous descriptions of this tumor. Meningeal sarcomas were subclassified into nine spindle cell sarcomas and ten fibrosarcomas. Among the rats with benign meningiomas, five were typical meningiomas (three fibroblastic meningiomas, and two meningothelial meningiomas) and 21 were meningothelial meningiomas containing cells with granules identical to those in granular cell tumors. There was a transition from epithelial-like cells of the meningothelial meningiomas to granular cells in these 21 cases. Based upon anatomic location, cytomorphologic similarities, and the occurrence of transitional or mixed forms of meningothelial meningiomas and granular cell tumors, it is suggested that these two tumors are related and may both originate from a common progenitor meningothelial arachnoid cell.

scholarly journals Hepatic Effects of Phthalate Esters and Related Compounds. In Vivo and In Vitro Correlations

1986 ◽  
Vol 67 ◽  
pp. 283 ◽  
Author(s):  
Brian G. Lake ◽  
Tim J. B. Gray ◽  
Sharat D. Gangolli
Keyword(s):  
Phthalate Esters ◽  
Related Compounds

Biological Activities of Steroids in Relation to Cancer

PEDIATRICS ◽  
1961 ◽  
Vol 27 (5) ◽  
pp. 754-754
Keyword(s):  
Cancer Chemotherapy ◽  
National Cancer Institute ◽  
Biological Activities ◽  
National Service ◽  
Service Center ◽  
Present Volume ◽  
And Function ◽  
Related Compounds

The cancer chemotherapy program of the National Cancer Institute (Cancer Chemotherapy National Service Center, CCNSC) includes a study of steroids in the treatment of various cancers, especially of the breast and prostrate. Within the first 2 years of formal activity of the nation-wide program, it became evident that intensive review and evaluation would be necessary to clarify its scope and function. To achieve this a conference was held, the proceedings of which form the present volume. To the pediatrician the word "steroid" probably means first and foremost "adrenocortical steroid" and may indicate to him that this book will deal primarily with cortisone and related compounds.

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