scholarly journals The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program.

1991 ◽  
Vol 96 ◽  
pp. 11-15 ◽  
Author(s):  
L S Gold ◽  
T H Slone ◽  
N B Manley ◽  
G B Garfinkel ◽  
E S Hudes ◽  
...  
Keyword(s):  
National Cancer Institute ◽  
Carcinogenic Potency ◽  
National Toxicology Program ◽  
The U.S

AIDS-Antiviral Natural Products Research at The U.S. National Cancer Institute

1992 ◽  
pp. 57-67 ◽  
Author(s):  
Kirk R. Gustafson ◽  
John H. Cardellina ◽  
Kirk P. Manfredi ◽  
John A. Beutler ◽  
James B. McMahon ◽  
...  
Keyword(s):  
Natural Products ◽  
National Cancer Institute ◽  
The U.S

scholarly journals A Possible Relationship Between Toxicity and Carcinogenicity

1986 ◽  
Vol 5 (2) ◽  
pp. 137-151 ◽  
Author(s):  
L. Zeise ◽  
E. A.C. Crouch ◽  
R. Wilson
Keyword(s):  
Acute Toxicity ◽  
National Cancer Institute ◽  
Chronic Toxicity ◽  
Positive Finding ◽  
National Toxicology Program ◽  
Technical Report Series ◽  
Technical Report ◽  
Highly Correlated ◽  
Relationship Of ◽  
The Relationship

Carcinogenic response is compared to noncarcinogenic toxicity in that group of chemicals tested by the National Cancer Institute (NCI) and National Toxicology Program (NTP) between 1976 and 1982 and reported in the Carcinogenesis Technical Report Series. A positive finding of carcinogenicity in the bioassay is correlated with the degree of noncarcinogenic chronic toxicity of the dose applied. Comparisons of acute toxicity (LD50) with carcinogenic potency show that they are correlated, but the correlation may in part be an artifact, since doses used in the NCI/NTP carcinogenesis bioassays are toxic and because reliable measures of potency can only be derived for positive carcinogenic responses. The high correlations for certain classes of chemicals and the relationship of chronic toxicity to positive carcinogenic finding suggest that these relationships are more than spurious. Since toxicities in different species are highly correlated, these findings imply that carcinogenicities in different species are also correlated.

Supplement to the Carcinogenic Potency Database (CPDB): Results of Animal Bioassays Published in the General Literature through 1997 and by the National Toxicology Program in 1997–1998

2005 ◽  
Vol 85 (2) ◽  
pp. 747-808 ◽  
Author(s):  
Lois Swirsky Gold ◽  
Neela B. Manley ◽  
Thomas H. Slone ◽  
Lars Rohrbach ◽  
Georganne Backman Garfinkel
Keyword(s):  
Carcinogenic Potency ◽  
National Toxicology Program
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