scholarly journals Recognition of major depressive disorder and its correlates among adult male patients in primary care

2018 ◽  
Vol 20 (3) ◽  
pp. 55-62 ◽  
Author(s):  
Sutanaya Pal ◽  
Rajat Oswal ◽  
Ganpat Vankar
Keyword(s):  
Primary Care ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Adult Male ◽  
Major Depressive ◽  
Male Patients

scholarly journals IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

2019 ◽  
Vol 57 ◽  
pp. 46-51 ◽  
Author(s):  
Suhaer Zeki Al-Fadhel ◽  
Hussein Kadhem Al-Hakeim ◽  
Arafat Hussein Al-Dujaili ◽  
Michael Maes
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Opioid Receptor ◽  
Regulatory System ◽  
Mu Opioid Receptor ◽  
Endogenous Opioids ◽  
Major Depressive ◽  
Mu Opioid ◽  
Male Patients ◽  
Drug Free

AbstractObjective:Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) and aberrations in endogenous opioids play a role in the pathophysiology of major depressive disorder (MDD). There are no studies which examined the associations between both systems in MDD. The aim of the present study was to examine the relation between β-Endorphin (β-EP), Endomorphin-2, and their mu-opioid receptor (MOR) as well as interleukin (IL)-6 and IL-10, an anti-inflammatory cytokine, in MDD patients.Method:The study included 60 depressed drug-free male patients and 30 matched controls. Serum β-EP, Endomorphin-2, MOR, IL-6 and IL-10 levels were measured using ELISA techniques.Results:The results revealed a significant increase in serum β-EP, MOR, IL-6 and IL-10 in MDD patients versus healthy controls. MOR levels were strongly associated with IL-10 levels. There were no significant correlations between endogenous opioids and IL-6 and IL-10.Conclusion:The results show that MOR levels may function as a possible component of the CIRS whilst there is no evidence that β-EP and EM-2 may modify the IRS. The significant correlation between MOR levels and IL-10 may be explained through central activation of the HPA-axis and increased B-cell numbers expressing MOR as a response to cytokine over-secretion in MDD.

scholarly journals Cost-effectiveness of collaborative care for the treatment of major depressive disorder in primary care. A systematic review

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Kirsten M van Steenbergen-Weijenburg ◽  
Christina M van der Feltz-Cornelis ◽  
Eva K Horn ◽  
Harm WJ van Marwijk ◽  
Aartjan TF Beekman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Primary Care ◽  
Major Depressive Disorder ◽  
Cost Effectiveness ◽  
Depressive Disorder ◽  
Collaborative Care ◽  
Major Depressive
Sign in / Sign up

Export Citation Format

Share Document