scholarly journals Early life adversity induced third ventricular enlargement in young adult male patients suffered from major depressive disorder: a study of brain morphology

2018 ◽  
Vol 77 (3) ◽  
pp. 428-433 ◽  
Author(s):  
H. Zhao ◽  
T. Wei ◽  
X. Li ◽  
T. Ba
Keyword(s):  
Major Depressive Disorder ◽  
Young Adult ◽  
Depressive Disorder ◽  
Adult Male ◽  
Early Life ◽  
Brain Morphology ◽  
Ventricular Enlargement ◽  
Major Depressive ◽  
Early Life Adversity ◽  
Male Patients

Effects of genetic variants on neural circuits in major depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 2085-2085
Author(s):  
T. Frodl
Keyword(s):  
Major Depressive Disorder ◽  
High Resolution ◽  
Cognitive Control ◽  
Depressive Disorder ◽  
Early Life ◽  
Brain Regions ◽  
High Angular Resolution ◽  
Major Depressive ◽  
Early Life Adversity ◽  
Brain Changes

IntroductionThe underlying neurobiology of major depressive disorder (MDD) is likely to represent an interaction between genetic susceptibility and environmental factors like stress. There is growing evidence that epigenetic processes might mediate the effects of the social environment during childhood on gene expression.ObjectivesWe investigated in multimodal high-resolution MRI-genetic studies whether microstructural and functional brain changes are the result of gene-environment interactions.MethodsPatients with major depressive disorder (MDD), high-risk subjects for developing MDD and healthy participants were investigated using high-resolution magnetic resonance imaging (MRI), high angular resolution diffusion imaging (HARDI) and functional MRI. Furthermore, we assessed early life adversity and measured the serotonin transporter polymorphisms (5-HTTLPR).ResultsWe demonstrated that patients with MDD have smaller hippocampal and frontal cortex volumes associated with gen-environment interactions. Healthy Subjects at risk for developing depression, who manage to stay healthy, show better activation of the frontal cognitive control system. Those who had stronger fibre connections between frontal and temporal brain regions also better managed incidences of adversity in early life.ConclusionsStress x gene interactions seem to account for at least some of the structural brain changes. Resilience against environmental stressors might be associated with stronger neural fibre connections and more effective cognitive control networks.

SU56EPIGENETIC REGULATION OF THE NOVEL EARLY LIFE ADVERSITY RESPONSIVE GENE MORC1 IN MAJOR DEPRESSIVE DISORDER

2019 ◽  
Vol 29 ◽  
pp. S1297
Author(s):  
Mara Thomas ◽  
Vanessa Nieratschker ◽  
Nadine Provençal ◽  
Andressa Coope dos Santos Botezelli
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Early Life ◽  
The Novel ◽  
Major Depressive ◽  
Early Life Adversity ◽  
Responsive Gene

scholarly journals IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

2019 ◽  
Vol 57 ◽  
pp. 46-51 ◽  
Author(s):  
Suhaer Zeki Al-Fadhel ◽  
Hussein Kadhem Al-Hakeim ◽  
Arafat Hussein Al-Dujaili ◽  
Michael Maes
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Opioid Receptor ◽  
Regulatory System ◽  
Mu Opioid Receptor ◽  
Endogenous Opioids ◽  
Major Depressive ◽  
Mu Opioid ◽  
Male Patients ◽  
Drug Free

AbstractObjective:Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) and aberrations in endogenous opioids play a role in the pathophysiology of major depressive disorder (MDD). There are no studies which examined the associations between both systems in MDD. The aim of the present study was to examine the relation between β-Endorphin (β-EP), Endomorphin-2, and their mu-opioid receptor (MOR) as well as interleukin (IL)-6 and IL-10, an anti-inflammatory cytokine, in MDD patients.Method:The study included 60 depressed drug-free male patients and 30 matched controls. Serum β-EP, Endomorphin-2, MOR, IL-6 and IL-10 levels were measured using ELISA techniques.Results:The results revealed a significant increase in serum β-EP, MOR, IL-6 and IL-10 in MDD patients versus healthy controls. MOR levels were strongly associated with IL-10 levels. There were no significant correlations between endogenous opioids and IL-6 and IL-10.Conclusion:The results show that MOR levels may function as a possible component of the CIRS whilst there is no evidence that β-EP and EM-2 may modify the IRS. The significant correlation between MOR levels and IL-10 may be explained through central activation of the HPA-axis and increased B-cell numbers expressing MOR as a response to cytokine over-secretion in MDD.

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