Pedagogical Conditions for Developing Structural Components of Students’ Genealogical Culture

10.12737/2868 ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 31-35
Author(s):  
Извеков ◽  
Igor Izvekov
Keyword(s):  
Family History ◽  
Character Education ◽  
Educational System ◽  
Publishing House ◽  
Educational Process ◽  
Structural Components ◽  
Teaching Aid ◽  
The Family ◽  
History Of

The paper discussed how to optimize moral and spiritual upbringing of competent to-be specialists in the student environment. The potential of genealogy (family) as a means of character education, yet-uninvolved by the educational system, is considered. According to the author’s viewpoint, this potential helps to nurture morality and spirituality through scientifically grounded study of the family history in the context of National History. The author also explores the teaching aid and educational program named «A History of Family in the National History: genealogy in the higher school educational process» published by INFRA-M publishing house (2013).

scholarly journals Novel SCN5A p.Val1667Asp Missense Variant Segregation and Characterization in a Family with Severe Brugada Syndrome and Multiple Sudden Deaths

2021 ◽  
Vol 22 (9) ◽  
pp. 4700
Author(s):  
Michelle M. Monasky ◽  
Emanuele Micaglio ◽  
Giuseppe Ciconte ◽  
Ilaria Rivolta ◽  
Valeria Borrelli ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Family History ◽  
Risk Stratification ◽  
Brugada Syndrome ◽  
Electrophysiological Study ◽  
Functional Characterization ◽  
The Family ◽  
Novel Variant ◽  
History Of ◽  
Scn5a Gene

Genetic testing in Brugada syndrome (BrS) is still not considered to be useful for clinical management of patients in the majority of cases, due to the current lack of understanding about the effect of specific variants. Additionally, family history of sudden death is generally not considered useful for arrhythmic risk stratification. We sought to demonstrate the usefulness of genetic testing and family history in diagnosis and risk stratification. The family history was collected for a proband who presented with a personal history of aborted cardiac arrest and in whom a novel variant in the SCN5A gene was found. Living family members underwent ajmaline testing, electrophysiological study, and genetic testing to determine genotype-phenotype segregation, if any. Patch-clamp experiments on transfected human embryonic kidney 293 cells enabled the functional characterization of the SCN5A novel variant in vitro. In this study, we provide crucial human data on the novel heterozygous variant NM_198056.2:c.5000T>A (p.Val1667Asp) in the SCN5A gene, and demonstrate its segregation with a severe form of BrS and multiple sudden deaths. Functional data revealed a loss of function of the protein affected by the variant. These results provide the first disease association with this variant and demonstrate the usefulness of genetic testing for diagnosis and risk stratification in certain patients. This study also demonstrates the usefulness of collecting the family history, which can assist in understanding the severity of the disease in certain situations and confirm the importance of the functional studies to distinguish between pathogenic mutations and harmless genetic variants.

Association between gastric cancer and the family history of gastric cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hyo Geun Choi ◽  
Wook Chun ◽  
Kuk Hyun Jung
Keyword(s):  
Gastric Cancer ◽  
Family History ◽  
The Family ◽  
History Of

scholarly journals Prostate cancer screening characteristics in men with BRCA1/2 mutations attending a high-risk prevention clinic

2014 ◽  
Vol 8 (11-12) ◽  
pp. 783 ◽  
Author(s):  
Richard Walker ◽  
Alyssa Louis ◽  
Alejandro Berlin ◽  
Sheri Horsburgh ◽  
Robert G. Bristow ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
High Risk ◽  
Prostate Cancer Screening ◽  
Brca2 Mutation ◽  
Aggressive Disease ◽  
Mutation Carriers ◽  
The Family ◽  
History Of ◽  
Prevention Clinic

Introduction: The prostate-specific antigen (PSA) era and resultant early detection of prostate cancer has presented clinicians with the challenge of distinguishing indolent from aggressive tumours. Mutations in the BRCA1/2 genes have been associated with prostate cancer risk and prognosis. We describe the prostate cancer screening characteristics of BRCA1/2 mutation carriers, who may be classified as genetically-defined high risk, as compared to another high-risk cohort of men with a family history of prostate cancer to evaluate the utility of a targeted screening approach for these men.Methods: We reviewed patient demographics, clinical screening characteristics, pathological features, and treatment outcomes between a group of BRCA1 or BRCA2 mutation carriers and age-matched men with a family history of prostate cancer followed at our institutional Prostate Cancer Prevention Clinic from 1995 to 2012.Results: Screening characteristics were similar between the mutation carriers (n = 53) and the family history group (n = 53). Some cancers would be missed in both groups by using a PSA cut-off of >4 ug/L. While cancer detection was higher in the family history group (21% vs. 15%), the mutation carrier group was more likely to have intermediate- or high-risk disease (88% vs. 36%). BRCA2 mutation carriers were more likely to have aggressive disease, biological recurrence, and distant metastasis.Conclusions: In our cohort, regular screening appears justified for detecting prostate cancer in BRCA1 and BRCA2 carriers and other high-risk populations. Lowering PSA cut-offs and defining monitoring of PSA velocity as part of the screening protocol may be useful. BRCA2 is associated with more aggressive disease, while the outcome for BRCA1 mutation carriers requires further study. Large multinational studies will be important to define screening techniques for this unique high-risk population.

scholarly journals The structure of the patriotic consciousness of youth: the pedagogical aspect

2019 ◽  
Vol 8 (3) ◽  
pp. 304-310
Author(s):  
Oksana Konstantinovna Pozdnyakova ◽  
Elena Leonidovna Krylova
Keyword(s):  
Structural Components ◽  
Family Work ◽  
Behavioral Component ◽  
Consciousness Development ◽  
The Family ◽  
Patriotic Education ◽  
History Of ◽  
Pedagogical Aspect ◽  
Systemic Development ◽  
Value Relations

In the framework of the younger generation patriotic education, a pedagogical task of young peoples patriotic consciousness development is being actualized. It is substantiated that the solution of this task requires clarification of the content of the notion young peoples patriotic consciousness, the meaning of which is understood when its structure and structural components content are revealed. Interpretations of patriotic consciousness are offered. They are proposed by modern Russian scientists who present it as a systemic development with its own structure. Structural components of the patriotic consciousness of youth are determined: a worldview component (knowledge, ideas, and views), an axiological component (values), a behavioral component (value relations). The possibility and necessity of the separation of these components is proved. The choice of specific concepts, values, and value relationships that form the content of the worldview, axiological, and behavioral components of the patriotic consciousness of youth is substantiated. The content of the ideological component of the patriotic consciousness of young people is revealed; it is formed by the knowledge, ideas, views on the concepts of patriotism, love for the Motherland, Motherland, small Motherland, Fatherland, patriot. In the context of understanding patriotism as a complex value represented through a set of values, it is proved that the content of the axiological component of youth patriotic consciousness is developed by the values of loyalty, heroism, pride in the Fatherland, duty, dignity, interest in the history of the Fatherland, culture, love of the country, courage, responsibility, family, tolerance, work, respect, honor. Valuable attitudes to the family, work, the Fatherland, culture are singled out as developing the content of the behavioral component of young peoples patriotic consciousness.

HEREDITARY AND ENVIRONMENTAL FACTORS IN THE PATHOGENESIS OF RHEUMATIC FEVER

PEDIATRICS ◽  
1957 ◽  
Vol 19 (5) ◽  
pp. 908-915
Author(s):  
Eugene F. Diamond
Keyword(s):  
Family History ◽  
Rheumatic Fever ◽  
Autosomal Recessive ◽  
Positive Family History ◽  
Recessive Gene ◽  
Environmental Groups ◽  
Environmental Group ◽  
The Family ◽  
History Of ◽  
Unfavorable Environmental Factor

A study of cases of rheumatic fever admitted to La Rabida Sanitarium over a 5-year period was carried out to evaluate heredity and environment as etiologic factors in rheumatic disease. The incidence of rheumatic fever was shown to be higher in families where one or both parents were known to have a positive family history of rheumatic fever. The incidence of rheumatic fever was compared in environmental groups. A totally unfavorable environment was shown to increase the incidence of rheumatic fever. No single unfavorable environmental factor changed the incidence of rheumatic fever. The incidence of rheumatic fever in each environmental group was higher when there was a positive family history for rheumatic fever, indicating an hereditary factor in the family incidence of rheumatic fever. Analysis of the various mating types in the families with a positive rheumatic trait was carried out. Agreement with a simple autosomal recessive gene inheritance was obtained in families where both parents had a definite family history, but no agreement was obtained in cases where only one parent gave a positive family history.

A Sax Is Born

2019 ◽  
pp. 3-10
Author(s):  
Con Chapman
Keyword(s):  
Family History ◽  
Birth Certificate ◽  
The South ◽  
The Family ◽  
History Of

This chapter provides data regarding Cornelius Hodges’s birth and traces his family history to his grandparents’ generation. Confusion as to the exact spelling of his last name (“Hodges,” not “Hodge”) is resolved by reference to his birth certificate. Census records reveal that, contrary to prior accounts of his life, he had not one sister but three, all older. The change in his name from “Cornelius” to “Johnny” is discussed, along with the seven nicknames that he was given by colleagues. The chapter also details the history of the Cambridge, Massachusetts, neighborhood where he was born—Cambridgeport—and of the South End of Boston, to which the family would move when he was twelve, after a stop in North Cambridge that has been overlooked in prior accounts of his life.

Plot and Theme in the Book of Ruth

2018 ◽  
Author(s):  
J. Andrew Dearman
Keyword(s):  
Family History ◽  
Short Story ◽  
Narrative Analysis ◽  
National History ◽  
The Family ◽  
History Of ◽  
The Town

This chapter explores plot and theme in the book of Ruth as an example of narrative analysis. The book is identified as a short story with a dilemma facing the family of Elimelech from the town of Bethlehem and the tribe of Judah. The family history of Elimelech and the role of the Moabite Ruth in it are examined first as a self-contained narrative and then in the context of Israel’s national history. The family dilemma is resolved with the birth of an heir for the family of Elimelech and the contribution of the family to the tribe of Judah to Israel’s national storyline is further revealed in the kingship of David, a descendant of Elimelech and Ruth.

scholarly journals P1.11-23 The Impact of the Family History of Different Cancers on Lung Cancer

2019 ◽  
Vol 14 (10) ◽  
pp. S524-S525
Author(s):  
J. Li ◽  
C. Li ◽  
B. Cheng ◽  
J. He ◽  
W. Liang
Keyword(s):  
Lung Cancer ◽  
Family History ◽  
The Family ◽  
History Of ◽  
The Impact
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