MOTION ACTIVITY OF AIRWAY CILIATED EPITHELIUM IN PATIENTS WITH ASTHMA

2016 ◽  
Vol 1 (62) ◽  
pp. 40-46
Author(s):  
Михаил Луценко ◽  
Mikhail Lutsenko
Keyword(s):  
Inflammatory Process ◽  
Mucociliary Clearance ◽  
Severe Form ◽  
Basal Bodies ◽  
Ciliated Epithelium ◽  
Epithelial Layer ◽  
Bronchial Mucosa ◽  
Ciliated Cells ◽  
Motion Activity ◽  
Mucociliary System

At asthma in bronchial mucous tunic as a result of chronic inflammatory process the working of mucociliary system is disturbed and there is restructuring of epithelial layer. The number of ciliary cells at the severe form of asthma decreases till 70%. The reason of restructuring of ciliated epithelium is the accumulation of a big number of fatty acids peroxides in the mucous tunic. Under their influence there is a decrease of activity of succinate dehydrogenase and ATP in the basal bodies of ciliary cells. Under the severe form of asthma there is a suppression of activity of mucociliary clearance as a result of destruction of a big number of bronchial mucosa ciliated cells.

scholarly journals THE CHARACTERISTIC OF MOTION ACTIVITY OF BRONCHIAL MUCOSA CILIATED EPITHELIUM CILIA AT OSMOTIC STRESS IN THE EXPERIMENT IN VITRO

2017 ◽  
Vol 1 (64) ◽  
pp. 29-36
Author(s):  
Одиреев ◽  
Andrey Odireev ◽  
Безруков ◽  
Nikolay Bezrukov ◽  
Перельман ◽  
...  
Keyword(s):  
Osmotic Stress ◽  
Ciliated Epithelium ◽  
Bronchial Mucosa ◽  
Motion Activity

Ciliary coordination in newt lung cells requires microtubule-based linkages between basal bodies: A correlative light and EM study

1992 ◽  
Vol 50 (1) ◽  
pp. 570-571
Author(s):  
Robert Hard ◽  
Gerald Rupp ◽  
Matthew L. Withiam-Leitch ◽  
Lisa Cardamone
Keyword(s):  
Basal Body ◽  
Untreated Control ◽  
Beat Frequency ◽  
Primary Cultures ◽  
Living Cells ◽  
Power Stroke ◽  
Ultrastructural Changes ◽  
Lung Cells ◽  
Basal Bodies ◽  
Ciliated Cells

In a coordinated field of beating cilia, the direction of the power stroke is correlated with the orientation of basal body appendages, called basal feet. In newt lung ciliated cells, adjacent basal feet are interconnected by cold-stable microtubules (basal MTs). In the present study, we investigate the hypothesis that these basal MTs stabilize ciliary distribution and alignment. To accomplish this, newt lung primary cultures were treated with the microtubule disrupting agent, Colcemid. In newt lung cultures, cilia normally disperse in a characteristic fashion as the mucociliary epithelium migrates from the tissue explant. Four arbitrary, but progressive stages of dispersion were defined and used to monitor this redistribution process. Ciliaiy beat frequency, coordination, and dispersion were assessed for 91 hrs in untreated (control) and treated cultures. When compared to controls, cilia dispersed more rapidly and ciliary coordination decreased markedly in cultures treated with Colcemid (2 mM). Correlative LM/EM was used to assess whether these effects of Colcemid were coupled to ultrastructural changes. Living cells were defined as having coordinated or uncoordinated cilia and then were processed for transmission EM.

Glycerol models of ciliated epithelium of the bronchial mucosa and their use for the diagnosis of chronic nonspecific lung diseases

1986 ◽  
Vol 101 (1) ◽  
pp. 105-107 ◽  
Author(s):  
N. A. Shanina ◽  
V. I. Gel'fand ◽  
I. I. Dykhanov ◽  
N. G. Bronza ◽  
N. N. Rozinova ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Ciliated Epithelium ◽  
Bronchial Mucosa

Influence of topical phenypropanolamine on tachyphylaxis and mucociliary clearance in the human nose

1988 ◽  
Vol 102 (5) ◽  
pp. 408-410 ◽  
Author(s):  
K. Holmberg ◽  
M. Bende
Keyword(s):  
Dose Response ◽  
Mucociliary Clearance ◽  
Mucociliary Transport ◽  
Cent Solution ◽  
Transport Time ◽  
Reduced Dose ◽  
Healthy Humans ◽  
Mucociliary System ◽  
Dose Response Effect ◽  
Human Nose

AbstractTopical nasal phenylpropanolamine in a 2.5 per cent solution (PPA) was used in an evaluation of the possible development of tachyphylaxis and of possible effects on the mucociliary system after one week of treatment in healthy humans. The tendency of PPA to produce tachyphylaxis was evaluated by rhi-nomanometrie measurements of nasal airway resistance after repeated dose-response provocations. The mucociliary transport time was tested with the saccharine-dye test. No reduced dose-response effect or change in mucociliary transport time was found with PPA, thus indicating that one week of treatment does not contribute to such adverse effects.

Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells

2004 ◽  
Vol 286 (4) ◽  
pp. L650-L657 ◽  
Author(s):  
Yingjian You ◽  
Tao Huang ◽  
Edward J. Richer ◽  
Jens-Erik Harboe Schmidt ◽  
Joseph Zabner ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Epithelial Cells ◽  
Basal Body ◽  
Ciliated Cell ◽  
Airway Epithelial Cells ◽  
Cell Phenotype ◽  
Basal Bodies ◽  
Airway Epithelial ◽  
Ciliated Cells ◽  
Wild Type

Factors required for commitment of an undifferentiated airway epithelial cell to a ciliated cell are unknown. Cell ultrastructure analysis indicates ciliated cell commitment activates a multistage program involving synthesis of cilia precursor proteins and assembly of macromolecular complexes. Foxj1 is an f-box transcription factor expressed in ciliated cells and shown to be required for cilia formation by gene deletion in a mouse model. To identify a specific role for foxj1 in directing the ciliated cell phenotype, we evaluated the capacity of foxj1 to induce ciliogenesis and direct cilia assembly. In a primary culture model of wild-type mouse airway epithelial cells, foxj1 expression preceded the appearance of cilia and in cultured foxj1 null cells cilia did not develop. Delivery of foxj1 to polarized epithelial cell lines and primary cultured alveolar epithelial cells failed to promote ciliogenesis. Similarly, delivery of foxj1 to wild-type airway epithelial cells did not enhance the total number of ciliated cells. In contrast, delivery of foxj1 to null cells resulted in the appearance of cilia. Analysis revealed that, in the absence of foxj1, null cells contained cilia precursor basal bodies, indicating prior commitment to ciliogenesis. However, the basal bodies were disorganized within the apical compartment and failed to dock with the apical membrane. Reconstitution of foxj1 in null cells restored normal basal body organization, resulting in axoneme growth. Thus foxj1 functions in late-stage ciliogenesis to regulate programs promoting basal body docking and axoneme formation in cells previously committed to the ciliated cell phenotype.

scholarly journals IV. Further note on the minute anatomy of the thymus

1882 ◽  
Vol 33 (216-219) ◽  
pp. 11-11
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Ciliated Epithelium ◽  
Ciliated Cells ◽  
Ciliated Epithelial Cells

Ciliated epithelial cells are found in the thymus of the dog: this is not the case in quite young animals, but ciliated epithelium can always be demonstrated in the thymus of a dog over thirty months old, and often in those of much younger animals. In the older dogs the ciliated cells are found lining cysts, and the cysts appeal to increase in size with the age of the animal. The ciliated epithelial cells take origin from connective tissue corpuscles. The connective tissue corpuscles forming the network in the medullary poition are in places massed together, forming concentric corpuscles of small size; in these masses small cavities are formed, and the lining cells are transformed into ciliated cells.

Detection of autoantibodies in patients with chronic bronchitis

1982 ◽  
Vol 63 (5) ◽  
pp. 51-53
Author(s):  
Yu. A. Osipov
Keyword(s):  
Chronic Bronchitis ◽  
Inflammatory Process ◽  
Direct Relationship ◽  
Bronchial Mucosa ◽  
Healthy Individuals ◽  
Chronic Inflammatory Process ◽  
Circulating Autoantibodies ◽  
High Level

In 120 patients with chronic bronchitis and 104 healthy individuals, circulating autoantibodies to the bronchial mucosa were studied. Exacerbation of the chronic inflammatory process in the bronchi is accompanied by a significant increase in autoantibody titers. A direct relationship was found between the level of autoantibodies, the severity and duration of the disease. By the time of discharge from the hospital in some patients, autoantibody titers remain at a high level, often up to six months. Determination of anti-bronchial antibodies in the dynamics of chronic bronchitis can be used to recognize the activity of the inflammatory process and predict its outcome.

Tracheal Resection and Mucociliary Clearance

1976 ◽  
Vol 85 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Anthony Giordano ◽  
Douglas S. Holsclaw
Keyword(s):  
Histological Examination ◽  
Functional Impairment ◽  
Mucociliary Clearance ◽  
Tracheal Resection ◽  
Ciliated Epithelium ◽  
Mucociliary Transport ◽  
Beagle Dogs ◽  
Clearance Rates ◽  
Resection And Anastomosis ◽  
Tracheal Mucus

Mucociliary transport following tracheal resection and end-to-end anastomosis was evaluated in beagle dogs, using the movement of 99MTC labeled sodium pertechnetate solution as a marker. Preoperatively, mucociliary clearance was stable, but a three-fold decrease in tracheal mucus movement was found three days postoperatively. Clearance rates had returned to normal by 31 days postoperatively and remained stable over a ten week period of observation. By histological examination, normal ciliated epithelium was seen within six months following resection and anastomosis. Since up to 25% (4 cm or seven tracheal rings) of tracheal length was removed, significant longitudinal loss can take place without functional impairment of mucociliary clearance. Circumferential narrowing, however, was associated with a significant decrease in clearance.

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