scholarly journals The Role of Pharmaceutical Care in Intractable Epilepsy

2010 ◽  
Vol 6 (1) ◽  
pp. 34-39
Author(s):  
Hiroyuki Ura ◽  
Ichiro Takumi ◽  
Osamu Fujino ◽  
Keiko Fukuda ◽  
Shiro Kobayashi ◽  
...  
Keyword(s):  
Pharmaceutical Care ◽  
Intractable Epilepsy

Potential effect of pharmaceutical care to improve outcomes in patients with chronic kidney disease-mineral bone disorder in Sulaimani dialysis centers

2020 ◽  
pp. 82-94
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pharmaceutical Care ◽  
Biochemical Parameters ◽  
Positive Impact ◽  
Potential Effect ◽  
Care Group ◽  
Mineral Bone Disorder ◽  
Bone Disorder

Objective: the present study was aimed to evaluate the role of pharmaceutical services in improving the outcome of mineral bone disorder in patients with advanced chronic kidney disease. Methodology: One hundred and twenty patients with chronic kidney disease-mineral bone disorder (CKD-MBD) screened for eligibility, seventy-six patients enrolled in the study and randomly allocated into two groups: pharmaceutical care and usual care, both groups interviewed by the pharmacist using specific questionnaire for assessing the quality of life (QoL). All the drug related problems (DRPs) including drug-drug interactions (DDIs) were recorded by the pharmacist. Blood samples were collected and utilized for analyzing the levels of vitamin D, phosphorous, calcium, albumin and parathyroid hormone at baseline and three months after. The pharmaceutical care group received all the educations about their medications and how to minimize DRPs; improve the QoL. Additionally, the pharmaceutical intervention included correcting the biochemical parameters. Results: Pharmaceutical care significantly improved patients QoL and minimized DRPs and DDIs. It was also effective in improving the biochemical parameters. Conclusion: Pharmaceutical care has a positive impact on improving the outcome of patients with CKD-MBD through attenuating DRPs, improving the biochemical parameters and the QoL.

scholarly journals The Neuroinflammatory Role of Pericytes in Epilepsy

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 759
Author(s):  
Gaku Yamanaka ◽  
Fuyuko Takata ◽  
Yasufumi Kataoka ◽  
Kanako Kanou ◽  
Shinichiro Morichi ◽  
...  
Keyword(s):  
Proinflammatory Cytokines ◽  
Current Knowledge ◽  
Morphological Changes ◽  
Cell Damage ◽  
Neurovascular Unit ◽  
Experimental Studies ◽  
Intractable Epilepsy ◽  
In Vivo Studies

Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of epilepsy has been investigated, and links between epilepsy and pericytes have been identified. Here, we review current knowledge about the role of pericytes in epilepsy. Clinical evidence has shown an accumulation of pericytes with altered morphology in the cerebral vascular territories of patients with intractable epilepsy. In vitro, proinflammatory cytokines, including IL-1β, TNFα, and IL-6, cause morphological changes in human-derived pericytes, where IL-6 leads to cell damage. Experimental studies using epileptic animal models have shown that cerebrovascular pericytes undergo redistribution and remodeling, potentially contributing to BBB permeability. These series of pericyte-related modifications are promoted by proinflammatory cytokines, of which the most pronounced alterations are caused by IL-1β, a cytokine involved in the pathogenesis of epilepsy. Furthermore, the pericyte-glial scarring process in leaky capillaries was detected in the hippocampus during seizure progression. In addition, pericytes respond more sensitively to proinflammatory cytokines than microglia and can also activate microglia. Thus, pericytes may function as sensors of the inflammatory response. Finally, both in vitro and in vivo studies have highlighted the potential of pericytes as a therapeutic target for seizure disorders.

scholarly journals PERSEPSI DOKTER TERHADAP PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI RUMAH SAKIT ROBERT WOLTER MONGISIDI MANADO

PHARMACON ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 357
Author(s):  
Ni Nengah S. Indiyani ◽  
Widya A. Lolo ◽  
Gerald Rundengan
Keyword(s):  
Pharmaceutical Care ◽  
Health Workers ◽  
Therapeutic Process ◽  
Health Sector ◽  
Care Physician ◽  
Data Collection Tool ◽  
Average Value ◽  
Quantitative Descriptive ◽  
Physician Perception

ABSTRACTServices in the health sector are one of the services that are needed by the community, one of them is service in the field of pharmacy. The therapeutic process of a patient needs collaboration between the pharmacist, physician and other health workers. In some hospitals in Indonesia, they have not implementing all pharmaceutical care activities as regulated in Permenkes No. 72 of 2016. This studied aims to know the opinions and expectations of physician to the role of pharmacist in pharmaceutical care. This research was a quantitative descriptive study and data collection tool used was a questionnaire about the opinions and expectations given to 63 physician. Based on the research results obtained, it was known that the perception of physician tend to agree with an average value of 94,55% for the opinion and for the expectation of 91,78%. So that can be concluded that physician had good opinions and expectation to the role of pharmacists in accordance with Pharmaceutical Care Standards.Key words : Pharmaceutical Care, Physician Perception, Pharmacists.ABSTRAK Pelayanan dalam bidang kesehatan merupakan salah satu pelayanan yang banyak di butuhkan oleh masyarakat, salah satunya adalah pelayanan dalam bidang kefarmasian. Proses terapi seorang pasien perlu adanya kerjasama antara apoteker, dokter dan tenaga kesehatan lainnya. Pada beberapa rumah sakit di Indonesia belum melakukan seluruh kegiatan pelayanan farmasi sebagaimana yang sudah di atur dalam Permenkes No. 72 Tahun 2016. Penelitian ini bertujuan untuk mengetahui pendapat dan harapan dokter terhadap peran apoteker dalam pelayanan kefarmasian. Penelitian ini merupakan penelitian deskriptif kuantitatif dan alat pengumpulan data yang digunakan berupa kuesioner tentang pendapat dan harapan yang diberikan kepada 63 dokter. Berdasarkan hasil penelitian yang diperoleh, diketahui bahwa  persepsi dokter cenderung setuju dengan nilai rata-rata untuk pendapat sebesar 94,55% dan untuk harapan sebesar 91,78%. Sehingga dapat disimpulkan bahwa dokter memiliki pendapat dan harapan yang baik terhadap peran apoteker sesuai dengan Standar Pelayanan Kefarmasian. Kata kunci : Pelayanan Kefarmasian, Persepsi Dokter, Apoteker.

Role of Reflexology and Antiepileptic Drugs in Managing Intractable Epilepsy - a Randomized Controlled Trial

2013 ◽  
Vol 20 (2) ◽  
pp. 6-6 ◽  
Author(s):  
Krishna Dalal ◽  
Elanchezhiyan Devarajan ◽  
Ravindra Mohan Pandey ◽  
Vivekanandan Subbiah ◽  
Manjari Tripathi
Keyword(s):  
Randomized Controlled Trial ◽  
Antiepileptic Drugs ◽  
Controlled Trial ◽  
Intractable Epilepsy ◽  
Randomized Controlled

Role of pharmaceutical care for self-administered pulmonary tuberculosis treatment in Thailand

2017 ◽  
Vol 42 (3) ◽  
pp. 337-344 ◽  
Author(s):  
P. Tanvejsilp ◽  
E. Pullenayegum ◽  
M. Loeb ◽  
J. Dushoff ◽  
F. Xie
Keyword(s):  
Pulmonary Tuberculosis ◽  
Pharmaceutical Care ◽  
Tuberculosis Treatment

Effective Pharmacist led interventional strategies to improve outcomes in hypertensive patients: a narrative review

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Samra Bashir ◽  
Akash Syed
Keyword(s):  
Pharmaceutical Care ◽  
Cost Effective ◽  
Pharmacist Intervention ◽  
Care Plan ◽  
Hypertensive Patients ◽  
Disease Outcomes ◽  
Cost Effective Alternative ◽  
The Impact

The role of pharmacist intervention as a cost-effective alternative to physician in disease management is increasingly been recognized. Studies have demonstrated that pharmaceutical care can improve drug therapy as well as patient satisfaction in chronic health conditions including cardiovascular diseases. This study is aimed to review and outline a comprehensive pharmaceutical care plan from the randomized controlled trials previously conducted to assess the impact of pharmacist-managed care on disease outcomes in hypertensive patients. Compared with usual care, the pharmaceutical intervention involved patient evaluation, patient education and counselling, medication review and management, patient monitoring and follow-up, and feedback to the primary physician as major strategies.

scholarly journals Pharmaceutical care in a school pharmacy: from consultation to resolution of drug-related problems

2019 ◽  
Vol 41 (1) ◽  
pp. 42470
Author(s):  
Amanda Thiemy Chiozzi Watanabe ◽  
Fernando Henrique Zonzini ◽  
Maurício Fumio Sybui ◽  
Angela Maria Campanha
Keyword(s):  
Pharmaceutical Care ◽  
Anatomical Therapeutic Chemical ◽  
Descriptive Analysis ◽  
State University ◽  
Drug Related Problems ◽  
Relevant Role ◽  
Professional Information ◽  
General Community

This study aimed to provide pharmaceutical care for the general community served by Pharmacy students from the Pharmacy School of the State University of Maringá [Universidade Estadual do Maringá] (UEM). Pharmacotherapeutic follow-up was performed with the identification, classification and resolution of drug-related problems (DRPs) through pharmaceutical consultations. A descriptive analysis was conducted. A total of 59 patients were interviewed; they were mostly women (75%) with average age of 63 years, and each of them was taking 8 medicines on average. The most frequently mentioned drugs were classified according to the Anatomical Therapeutic Chemical Code and related to cardiovascular system (28%), alimentary tract and metabolism (23%), and nervous system (20%). An average of 1.49 DRP per patient was detected (88), and treatment non-compliance was the most frequent DRPs found (45%). In view of this, 63 pharmaceutical interventions were carried out, with most of them (52%) being related to patient education on the treatment; approximately 20% of the patients were referred to another health professional. Information supplied by this study shows the relevant role of pharmacists face the lack of pharmacotherapeutic follow-up of polymedicated patients.

scholarly journals Pharmaceutical Care in Sports

Pharmacy ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 218
Author(s):  
José Henrique Gialongo Gonçales Bomfim
Keyword(s):  
Physical Activity ◽  
Adverse Events ◽  
Pharmaceutical Care ◽  
Herbal Drugs ◽  
Clinical Services ◽  
Drug Related Problems ◽  
Health Team ◽  
As Doping

Pharmaceutical care in sports is a new field of work to clinical pharmacists, focused on promoting pharmacotherapeutic follow up and clinical services to athletes, physical activity practitioners and enthusiasts of any sports modality. A broad range of pharmaceuticals, dietary supplements and herbal drugs have been used historically as performance promoters, doping or ergogenic aids. In this context, the role of pharmacists in prevent adverse events, drug interactions or any drug related problems, as doping issues, was described. Its actions can be important to contribute with a multi professional clinical health team, leading athletes to use these resources in a rational way, promoting and optimizing the therapeutic when its necessary.

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