scholarly journals Effects of Metal Ions and pH on the Stability of Linoleic Acid Hydroperoxide in the Water Phase

1997 ◽  
Vol 61 (12) ◽  
pp. 1973-1976 ◽  
Author(s):  
Tamako Nishiike ◽  
Satoko Kondo ◽  
Tamae Yamamoto ◽  
Aya Shigeeda ◽  
Yoshimi Yamamoto ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Metal Ions ◽  
Water Phase ◽  
Linoleic Acid Hydroperoxide ◽  
Acid Hydroperoxide ◽  
The Stability

scholarly journals Effects of Amino Acids, Sugars, and Ascorbic Acid on the Stability of Linoleic Acid Hydroperoxide in the Water Phase

1999 ◽  
Vol 63 (11) ◽  
pp. 1997-2000 ◽  
Author(s):  
Tamako NISHIIKE ◽  
Jun ICHIKAWA ◽  
Noriko KIKUGAWA ◽  
Hitoshi TAKAMURA ◽  
Teruyoshi MATOBA
Keyword(s):  
Amino Acids ◽  
Ascorbic Acid ◽  
Linoleic Acid ◽  
Water Phase ◽  
Linoleic Acid Hydroperoxide ◽  
Acid Hydroperoxide ◽  
The Stability

Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles

1969 ◽  
Vol 47 (5) ◽  
pp. 485-492 ◽  
Author(s):  
P. J. O'Brien
Keyword(s):  
Catalytic Activity ◽  
Linoleic Acid ◽  
Metal Ions ◽  
Ph Dependence ◽  
Lipid Peroxide ◽  
Transition Metal Ions ◽  
Complexing Agents ◽  
Linoleic Acid Hydroperoxide ◽  
Hydrogen Donors ◽  
Acid Hydroperoxide

Linoleic acid hydroperoxide was prepared. Two types of mechanisms for its decomposition were found. The hydroperoxide was rapidly decomposed by certain transition metal ions, heme, and hemoprotein to a complex range of products, the decomposition being accompanied by changes in ultraviolet absorption spectra. The production of radical oxidizing species may account for these products. It was also found that the hydroperoxide could be decomposed by nucleophiles presumably in a nonradical reaction to a hydroxy acid without any change in ultraviolet spectra.The kinetics, the pH dependence, and the effects of metal-complexing agents, inhibitors, and hydrogen donors on the catalytic activity of the metal ions and heme compounds were also investigated.

scholarly journals Interaction between Mitochondrial Cytochromes and Linoleic Acid Hydroperoxide

1982 ◽  
Vol 69 (6) ◽  
pp. 1308-1314 ◽  
Author(s):  
Jacques Dupont ◽  
Pierre Rustin ◽  
Claude Lance
Keyword(s):  
Linoleic Acid ◽  
Linoleic Acid Hydroperoxide ◽  
Acid Hydroperoxide ◽  
Mitochondrial Cytochromes

scholarly journals Flavonoids Suppress the Cytotoxicity of Linoleic Acid Hydroperoxide toward PC12 Cells

2002 ◽  
Vol 25 (8) ◽  
pp. 1093-1096 ◽  
Author(s):  
Naoko Sasaki ◽  
Takeshi Toda ◽  
Takao Kaneko ◽  
Naomichi Baba ◽  
Mitsuyoshi Matsuo
Keyword(s):  
Linoleic Acid ◽  
Pc12 Cells ◽  
Linoleic Acid Hydroperoxide ◽  
Acid Hydroperoxide

Intracellular mechanisms for the decomposition of a lipid peroxide. II. Decomposition of a lipid peroxide by subcellular fractions

1969 ◽  
Vol 47 (5) ◽  
pp. 493-499 ◽  
Author(s):  
P. J. O'Brien ◽  
C. Little
Keyword(s):  
Linoleic Acid ◽  
Glutathione Peroxidase ◽  
Ph Dependence ◽  
Lipid Peroxide ◽  
Subcellular Fractions ◽  
Radical Mechanism ◽  
Complexing Agents ◽  
Linoleic Acid Hydroperoxide ◽  
Hydrogen Donors ◽  
Acid Hydroperoxide

The properties of subcellular fractions of rat liver in catalyzing the decomposition of linoleic acid hydroperoxide have been compared with those of transition salts, heme compounds, and nucleophiles. The properties compared included the range of products produced, the pH dependence of the reaction, and the effects of metal-complexing agents, inhibitors, and hydrogen donors. It was concluded that the decomposition of the hydroperoxide in the liver cell was due principally to reaction with the intracellular nucleophile glutathione by a mechanism catalyzed by the enzyme glutathione peroxidase. In the absence of glutathione, however, both the mitochondrial and microsomal fractions decomposed the hydroperoxide presumably by a radical mechanism probably involving the cytochromes.

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