scholarly journals Whole-body retention and fetal uptake of 65Zn in pregnant mice fed a Zn-deficient diet.

1995 ◽  
Vol 36 (3) ◽  
pp. 196-202 ◽  
Author(s):  
NAONORI MATSUSAKA ◽  
HIDEKI SAKAMOTO ◽  
ITARU SATO ◽  
KUNIHIRO SHINAGAWA ◽  
HARUO KOBAYASHI ◽  
...  
Keyword(s):  
Whole Body ◽  
Deficient Diet ◽  
Body Retention ◽  
Pregnant Mice ◽  
Fetal Uptake

scholarly journals The effects of phytate on intestinal absorption and secretion of zinc, and whole-body retention of Zn, copper, iron and manganese in rats

1975 ◽  
Vol 34 (2) ◽  
pp. 243-258 ◽  
Author(s):  
N. T. Davies ◽  
R. Nightingale
Keyword(s):  
Growth Rate ◽  
Food Intake ◽  
Young Male ◽  
The Body ◽  
Male Rats ◽  
Whole Body ◽  
Zn Deficiency ◽  
Cyclic Pattern ◽  
Deficient Diet ◽  
Body Retention

1. The inclusion of phytate (10 g/kg) in a purified diet containing zinc (15 mg/kg) fed to young male rats significantly reduced growth rate and food intake, and promoted a cyclic pattern of food intake characteristic of an uncomplicated Zn deficiency. The decreased growth rate could be accounted for by the reduced food consumption.2. Rats maintained on a Zn-deficient diet (0.5 mg Zn/kg) were found to have a cyclic pattern of food intake and a very slight weight gain. The addition of phytate (10 g/kg) to the Zn-deficient diet promoted a net loss of mean body-weight.3. Rats maintained on the Zn-supplemented diet containing phytate excreted significantly more Zn in their faeces than either pair-fed or ad lib.-fed control rats. Rats given the Zn-deficient diet supplemented with phytate excreted more Zn in their faeces than Zn-deficient control rats.4. Dietary phytate significantly reduced the average daily accumulation (μg/d) and wholebody retention (relative to dietary intake) of iron, copper, manganese and Zn, whether or not the diet was supplemented with Zn.5. The addition of phytate to the lumen fluid of ligated loops of rat duodenum maintained in situ significantly inhibited 65Zn absorption, compared with the control systems without added phytate.6. Other studies using ligated duodenal and ileal loops indicated that Zn is secreted into the gut lumen and approximately one-third of this is normally reabsorbed. Recycling of endogenous Zn may be a significant process in the over-all body economy of this trace element.7. The absorption of 65Zn added to the diet was significantly reduced by dietary phytate. Dietary phytate also reduced the biological half-life of body 65Zn from 91 to 211 h post-administration, possibly by inhibiting reabsorption of endogenous 65Zn and thus promoting a more rapid loss from the body.

Radioimmunszintigraphie mit SPECT: Methodik, Probleme und klinische Erfahrungen

1987 ◽  
Vol 26 (05) ◽  
pp. 202-205 ◽  
Author(s):  
J. Fass ◽  
S. Truong ◽  
U. Büll ◽  
V. Schumpelick ◽  
R. Bares
Keyword(s):  
Clinical Practice ◽  
The Other ◽  
Whole Body ◽  
Blood Clearance ◽  
Planar Scintigraphy ◽  
Gastrointestinal Carcinomas ◽  
Body Regions ◽  
Other Hand ◽  
Body Retention ◽  
Klinische Erfahrungen

Radioimmunoscintigraphy (RIS) with 111ln- and 131 I-labelled monoclonal anti bodies (MAbs) against CEA and/or CA 19-9 was performed in 83 patients with various gastrointestinal carcinomas. A total of 276 body regions could be examined. The results of planar scintigraphy and SPECT were compared intraindividually. Using 111 In-labelled MAbs the sensitivity of RIS was significantly improved by SPECT (88.9 vs. 52.4% with planar scintigraphy, p <0.01). For131 l-labelled MAbs the effect was smaller (83.9 vs. 65.6% with planar scintigraphy, n.s.). This finding can be explained by different kinetics and biodistribution of the used MAb preparations.111 In-labelled MAbs with long whole-body retention and rapid blood clearance reveal ideal qualities for SPECT; on the other hand, the short whole-body retention of131 l-labelled MAbs leads to small count rates and therefore long counting times that make delayed SPECT unsuitable in clinical practice

scholarly journals Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2169
Author(s):  
Dominique Bayle ◽  
Cécile Coudy-Gandilhon ◽  
Marine Gueugneau ◽  
Sara Castiglioni ◽  
Monica Zocchi ◽  
...  
Keyword(s):  
Gastrocnemius Muscle ◽  
Magnesium Deficiency ◽  
Mitochondrial Dynamics ◽  
Body Weight Gain ◽  
Whole Body ◽  
Muscle Physiology ◽  
Deficient Diet ◽  
Muscle Weight ◽  
Magnesium Homeostasis ◽  
Expression Of Genes

Chronic Mg2+ deficiency is the underlying cause of a broad range of health dysfunctions. As 25% of body Mg2+ is located in the skeletal muscle, Mg2+ transport and homeostasis systems (MgTHs) in the muscle are critical for whole-body Mg2+ homeostasis. In the present study, we assessed whether Mg2+ deficiency alters muscle fiber characteristics and major pathways regulating muscle physiology. C57BL/6J mice received either a control, mildly, or severely Mg2+-deficient diet (0.1%; 0.01%; and 0.003% Mg2+ wt/wt, respectively) for 14 days. Mg2+ deficiency slightly decreased body weight gain and muscle Mg2+ concentrations but was not associated with detectable variations in gastrocnemius muscle weight, fiber morphometry, and capillarization. Nonetheless, muscles exhibited decreased expression of several MgTHs (MagT1, CNNM2, CNNM4, and TRPM6). Moreover, TaqMan low-density array (TLDA) analyses further revealed that, before the emergence of major muscle dysfunctions, even a mild Mg2+ deficiency was sufficient to alter the expression of genes critical for muscle physiology, including energy metabolism, muscle regeneration, proteostasis, mitochondrial dynamics, and excitation–contraction coupling.

scholarly journals Improved zinc and iron absorption from breakfast meals containing malted oats with reduced phytate content

1996 ◽  
Vol 76 (5) ◽  
pp. 677-688 ◽  
Author(s):  
Marie Larsson ◽  
Lena Rossander-Hulthén ◽  
Brittmarie Sandström ◽  
Ann-Sofie Sandberg
Keyword(s):  
Iron Absorption ◽  
Human Subjects ◽  
Vulnerable Groups ◽  
Whole Body ◽  
Absolute Amount ◽  
Average Increase ◽  
Mineral Deficiency ◽  
Breakfast Meal ◽  
Body Retention ◽  
Phytate Content

The absorption of Zn or Fe from breakfast meals containing oat porridge prepared from malted and soaked oats and a control porridge made from untreated oats was measured in human subjects. The effect on Zn and Fe absorption of reducing the phytate content of oat-porridge meals was examined in each subject by extrinsic labelling of porridge with 65Zn and of bread rolls with 55Fe and 59Fe, and measuring whole-body retention and the erythrocyte uptake of isotopes. Each experiment comprised nine to ten subjects. The absorption of Zn from malted-oat porridge with a phytate (inositol hexaphosphate) content of 107 μmol was 18·3%, and significantly higher (P < 0·05) than from the control porridge containing 432 μmol phytate (11·8%). Fe absorption from the meal containing malted-oat porridge with 107 μmol phytate (Expt 2) was also significantly improved (P < 0·05) compared with that from the meal containing control porridge with 437 μmol phytate. The average increase in Fe absorption was 47%, or from 4·4 to 6·0%. In the breakfast meal containing malted porridge with 198 μmol phytate (Expt 3) the increase in Fe absorption was not significantly improved. Even though the phytate content was reduced to a greater extent in Expt 3 than Expt 2, the average increase in Fe absorption in Expt 3 was only 25% more than that from the meal containing control porridge (with 599 μmol phytate), depending on the higher absolute amount of phytate. In conclusion, an improvement in Zn and Fe absorption from oat products can be achieved by practising malting and soaking in the processing of oats. This may be of importance in the prevention of mineral deficiency in vulnerable groups.

Gastrointestinal iron and cobalt absorption and iron status in young rats and guinea pigs

1995 ◽  
Vol 14 (12) ◽  
pp. 949-954 ◽  
Author(s):  
Gpl Naylor ◽  
JD Harrison
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Iron Status ◽  
Age Groups ◽  
Gastrointestinal Absorption ◽  
Whole Body ◽  
Suckling Period ◽  
Young Rats ◽  
Body Retention ◽  
Different Ages

The gastrointestinal absorption of Fe and Co by rats and guinea pigs of different ages was measured by comparing the whole-body retention of 59Fe and 57Co after oral and intraperitoneal administrations. The age-groups studied included newborn, weanlings and adults. The absorption of both Fe and Co decreased markedly with age in both rats and guinea pigs. In the rat, absorption remained ele vated during the suckling period, while in the guinea pig absorption decreased markedly during suckling. In both species, Fe and Co absorption were similar, and remained elevated above adult values for some time after weaning. The generally greater absorption of Fe and Co by rats than by guinea pigs and the longer duration of maximal absorp tion in the rats may have involved differences in Fe status in the two species and differences in the timing of gut mat uration.

scholarly journals Whole-body Retention and Tissue Distribution of Cesium-134 in New-born, Young and Adult Rats

1967 ◽  
Vol 8 (3-4) ◽  
pp. 132-140 ◽  
Author(s):  
Jiro INABA ◽  
Naonori MATSUSAKA ◽  
Ryushi ICHIKAWA
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Adult Rats ◽  
New Born ◽  
Body Retention

scholarly journals Comparison of whole body retention of I-131 in case humans thyroid cancer between model prediction and measurement

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Brudecki Kamil ◽  
Mroz Tomasz ◽  
Janowski Paweł ◽  
Lorenc-Brudecka Jadwiga
Keyword(s):  
Thyroid Cancer ◽  
Model Prediction ◽  
Whole Body ◽  
Body Retention

Blut-Hirn-Schranke und Placentar-Schranke für H-Thymidin und H-Cytidin bei der Maus / Blood-Brain-Barrier and Placental-Barrier for H-Thymidine and H-Cytidine in the Mouse

1972 ◽  
Vol 27 (5) ◽  
pp. 554-558b ◽  
Author(s):  
B. Schultze ◽  
N. Hörning ◽  
W. Maurer
Keyword(s):  
Blood Brain Barrier ◽  
Intravenous Injection ◽  
Brain Barrier ◽  
Whole Body ◽  
Placental Barrier ◽  
Whole Body Autoradiography ◽  
Blood Brain ◽  
Pregnant Mice ◽  
Distribution In The Organism

The distribution in the organism of the mouse of free 3H-thymidine and 3H-cytidine was studied 1, 2½, 5 and 15 minutes after intravenous injection into normal and pregnant mice (20th day) using whole body autoradiography. The grain density measured over brain and fetus is 10 times smaller as compared to other tissues of the organism. This means that a blood brain barrier and placental barrier for thymidine and cytidine exists.

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