scholarly journals High SET Domain Bifurcated 1 (SETDB1) Expression Predicts Poor Prognosis in Breast Carcinoma

2020 ◽  
Vol 26 ◽  
Author(s):  
Zhaoping Zhou ◽  
Baojin Wu ◽  
Xinjie Tang ◽  
Wenlin Yang ◽  
Qiang Zou ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Set Domain ◽  
High Set

Expression ofRPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis

2005 ◽  
Vol 117 (6) ◽  
pp. 934-941 ◽  
Author(s):  
Selina Raguz ◽  
Manuela Tamburo De Bella ◽  
Martin J. Slade ◽  
Christopher F. Higgins ◽  
R. Charles Coombes ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Interacting Protein

scholarly journals SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma

2014 ◽  
Vol 15 (15) ◽  
pp. 6065-6070 ◽  
Author(s):  
Anongruk Chim-ong ◽  
Charin Thawornkuno ◽  
Porntip Chavalitshewinkoon-Petmitr ◽  
Phaibul Punyarit ◽  
Songsak Petmitr
Keyword(s):  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma

scholarly journals The multiple myeloma–associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity

Blood ◽  
2008 ◽  
Vol 111 (2) ◽  
pp. 856-864 ◽  
Author(s):  
Josh Lauring ◽  
Abde M. Abukhdeir ◽  
Hiroyuki Konishi ◽  
Joseph P. Garay ◽  
John P. Gustin ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Poor Prognosis ◽  
Target Genes ◽  
Hematologic Malignancy ◽  
Growth Factor Receptor ◽  
Cellular Adhesion ◽  
Tumor Formation ◽  
Set Domain ◽  
Cycle Arrest

Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal translocations. Patients with t(4;14)(p16;q32) are the worst prognostic subgroup in MM, although the basis for this poor prognosis is unknown. The t(4;14) is unusual in that it involves 2 potential target genes: fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET). MMSET is universally overexpressed in t(4;14) MM, whereas FGFR3 expression is lost in one-third of cases. Nonetheless, the role of MMSET in t(4;14) MM has remained unclear. Here we demonstrate a role for MMSET in t(4;14) MM cells. Down-regulation of MMSET expression in MM cell lines by RNA interference and by selective disruption of the translocated MMSET allele using gene targeting dramatically reduced colony formation in methylcellulose but had only modest effects in liquid culture. In addition, MMSET knockdown led to cell-cycle arrest of adherent MM cells and reduced the ability of MM cells to adhere to extracellular matrix. Finally, MMSET knockdown and knockout reduced tumor formation by MM xenografts. These results provide the first direct evidence that MMSET plays a significant role in t(4;14) MM and suggest that therapies targeting this gene could impact this particular subset of poor-prognosis patients.

IMP3 contributes to poor prognosis of patients with metaplastic breast carcinoma: A clinicopathological study

2017 ◽  
Vol 31 ◽  
pp. 30-35 ◽  
Author(s):  
Ryuji Ohashi ◽  
Maoka Sangen ◽  
Shigeki Namimatsu ◽  
Hiroyuki Takei ◽  
Zenya Naito
Keyword(s):  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Clinicopathological Study ◽  
Metaplastic Breast Carcinoma

scholarly journals Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Kaouther Snoussi ◽  
A Donny Strosberg ◽  
Noureddine Bouaouina ◽  
Slim Ben Ahmed ◽  
A Noureddine Helal ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Leptin Receptor ◽  
Increased Risk
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