scholarly journals High Survivin and Low Zinc Finger of the Cerebellum 1 Expression Indicates Poor Prognosis in Triple-negative Breast Carcinoma

2019 ◽  
Vol 22 (2) ◽  
pp. 248 ◽  
Author(s):  
Chun-Tao Shi ◽  
Jun Ma ◽  
Qi-Feng Shi ◽  
Ye Zhang ◽  
Hao-Nan Wang
Keyword(s):  
Breast Carcinoma ◽  
Zinc Finger ◽  
Poor Prognosis ◽  
Triple Negative ◽  
Triple Negative Breast Carcinoma

Higher CD1a Levels Correlate with PD-L1 Expression and Predict Worse Overall Survival in Triple-Negative Breast Carcinoma

Breast Care ◽  
2021 ◽  
pp. 1-9
Author(s):  
Jian Zheng ◽  
Yuntao Wei ◽  
Xiaoxi Li ◽  
Zhan Shen ◽  
Yong Zhang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Triple Negative ◽  
Carcinoma Tissue ◽  
Kaplan Meier ◽  
Immature Dendritic Cells ◽  
Triple Negative Breast Carcinoma ◽  
High Median

Objective: The aim of this study was to measure the expression of PD-L1, CD1a (a marker for immature dendritic cells), and CD83 (a marker for mature dendritic cells) and further examine the associations of PD-L1, CD83, and CD1a with overall survival (OS) in triple-negative breast carcinoma patients. Methods: PD-L1, CD1a, and CD83 expression in breast carcinoma tissues and CD83 expression in lymph node tissues were examined by immunohistochemistry and tissue microarray in 159 patients. Patients were classified into the low, medium, and high PD-L1, CD1a, and CD83 levels. Pearson χ2 test was used to analyze the correlations between PD-L1, CD1a, and CD83. The Kaplan-Meier method was used to calculate the OS. Multivariate analysis was used to identify determinants of 3- and 5-year OS. Results: 25.1, 25.8, and 49.1% of the patients had low, medium, and high PD-L1 levels, respectively. PD-L1 levels significantly correlated with CD1a (r = 0.30409, p < 0.001) and CD83 levels (r = 0.6146, p < 0.001) in breast carcinoma tissue, as well as CD83 levels (r = 0.17508, p = 0.027) in lymph node. The median OS was 83 months (range 12–106), and the 3- and 5-year OS rates were 94.97% (95% CI 91.57–98.37) and 86.79% (95% CI 81.53–92.06), respectively. Moreover, patients with high median CD1a levels had a significantly lower 5-year OS rate (75.6%) than those with low median CD1a levels (93.5%, p = 0.038). Conclusion: PD-L1, CD1a, and CD83 are variably expressed in triple-negative breast carcinoma tissues, and PD-L1 expression correlates with CD1a and CD83. Higher CD1a levels correlate with PD-L1 expression and predict worse OS in triple-negative breast carcinoma.

scholarly journals A STUDY ON THE HISTONE METHYLTRANSFERASE ENHANCER OF ZESTE HOMOLOG 2 EXPRESSION IN BREAST CARCINOMA

2020 ◽  
pp. 66-68
Author(s):  
Rubaiya Ahmad ◽  
Syed Meraj Imam ◽  
Debarshi Jana
Keyword(s):  
Breast Carcinoma ◽  
Breast Tumor ◽  
Triple Negative ◽  
Histone Methyltransferase ◽  
Expression Level ◽  
High Grade ◽  
Over Expression ◽  
Ezh2 Expression ◽  
Triple Negative Breast Carcinoma ◽  
Enhancer Of Zeste

The over expression of EZH2 in Breast Carcinoma. Compare EZH2 expression in different immunophenotypes of breast carcinoma(basal, luminal, triple-negative). The study EZH2 expression level in association to staging and grading of breast carcinoma Patients attending the Dept of Pathology, Sri Krishna Medical Collage Muzaffarpur, Bihar with epithelial breast tumor. We found that EZH2 in Breast Carcinoma was significantly associated with grade of the tumour. EZH2 was significantly associated with stage of the tumour. It was found that EZH2 was significantly correlated with ki67 in Breast Carcinoma patients. Triple negative Breast Carcinoma patient was significantly associated with high grade of EZH2 tumour.

scholarly journals Subtyping Of Triple Negative Breast Carcinoma On The Basis Of RTK Expression

2018 ◽  
Vol 9 (15) ◽  
pp. 2589-2602 ◽  
Author(s):  
Harald Hessel ◽  
Manuela Poignée-Heger ◽  
Sabine Lohmann ◽  
Bianca Hirscher ◽  
Andrea Herold ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Triple Negative ◽  
Triple Negative Breast Carcinoma

scholarly journals Cytologic features of triple-negative breast carcinoma

2012 ◽  
Vol 120 (6) ◽  
pp. 401-409 ◽  
Author(s):  
Mariella Bonzanini ◽  
Luca Morelli ◽  
Elena Maria Bonandini ◽  
Elena Leonardi ◽  
Riccardo Pertile ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Triple Negative ◽  
Triple Negative Breast Carcinoma
Sign in / Sign up

Export Citation Format

Share Document