Scale-up of L-lactic acid production by mutant strain Rhizopus sp. MK-96-1196 from 0.003 m3 to 5 m3 in airlift bioreactors

2006 ◽  
Vol 101 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Tiejun Liu ◽  
Shigenobu Miura ◽  
Masaaki Yaguchi ◽  
Tomohiro Arimura ◽  
Enock Y. Park ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Mutant Strain ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Scale Up ◽  
Airlift Bioreactors ◽  
Rhizopus Sp

Optimization and scale-up of l-lactic acid fermentation by mutant strain Rhizopus sp. MK-96-1196 in airlift bioreactors

2003 ◽  
Vol 96 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Shigenobu Miura ◽  
Tomohiro Arimura ◽  
Minako Hoshino ◽  
Mami Kojima ◽  
Lies Dwiarti ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Mutant Strain ◽  
Scale Up ◽  
Lactic Acid Fermentation ◽  
Acid Fermentation ◽  
Airlift Bioreactors ◽  
Rhizopus Sp

scholarly journals Effects of temperature and neutralizing agent on lactic acid production by Rhizopus sp. fermentation

2021 ◽  
Author(s):  
Whiny Erliana ◽  
Tri Widjaja ◽  
Tectona Indah ◽  
Daryl Susilo ◽  
Annisa Dewi
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Neutralizing Agent ◽  
Effects Of Temperature ◽  
Rhizopus Sp

Optimization and scale-up of a new bacterial bioprocess for lactic acid production

2016 ◽  
Vol 231 ◽  
pp. S7
Author(s):  
Anita Slavica ◽  
Renata Teparic ◽  
Bozidar Šantek ◽  
Srdjan Novak
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Scale Up

scholarly journals CO-PRODUCTION OF LACTIC ACID AND ETHANOL USING RHIZOPUS SP. FROM HYDROLYZED INEDIBLE CASSAVA STARCH AND LEAVES

2016 ◽  
Vol 17 (2) ◽  
pp. 1-10 ◽  
Author(s):  
Azlin Suhaida Azmi ◽  
Nurlisa Yusuf ◽  
Dzun Noraini Jimat ◽  
Noor Illi Mohamad Puad
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Cassava Starch ◽  
Optimum Conditions ◽  
Glucose Yield ◽  
Cassava Leaves ◽  
Ethanol Yields ◽  
Rhizopus Sp ◽  
Hydrolysis Of

Production of lactic acid and ethanol from inedible cassava starch and leaves was investigated. Prior to fermentation, hydrolysis of the starch and leaves was conducted. Hydrolysis was optimized by manipulating at three levels each four particular factors, namely acid concentration, starch concentration, temperature, and reaction time. Maximum glucose yield of 0.96 g/g was obtained when 2.5% (w/v) of cassava leaves with 2.5% (w/v) of starch was hydrolyzed using 0.20 M of nitric acid at 160oC of temperature for 10 min. The potential of hydrolyzed cassava starch and leaves was then investigated for lactic acid production using fungal Rhizopus sp. The fermentation process was then conducted in shake flask by varying four factors at three levels each. Maximum lactic acid and ethanol yields of 0.95 g/g and 0.52 g/g, respectively, were achieved at different optimum conditions.  Lactic acid production was found to be linked to a decrease in ethanol production. Design Expert v6.0.8 was used to aid in the design of the experiment using Taguchi’s methodology.

scholarly journals Upscale fermenter design for lactic acid production from cheese whey permeate focusing on impeller selection and energy optimization

2021 ◽  
Author(s):  
Maneesh Kumar Mediboyina ◽  
Nicholas M. Holden ◽  
Simon O’Neill ◽  
Kai Routledge ◽  
Bill Morrissey ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Energy Consumption ◽  
Acid Production ◽  
Cheese Whey ◽  
Lactic Acid Production ◽  
Scale Up ◽  
Specific Energy Consumption ◽  
Accurate Estimation ◽  
Whey Permeate ◽  
Cheese Whey Permeate

AbstractThis study focusses on the design and scale-up of industrial lactic acid production by fermentation of dairy cheese whey permeate based on standard methodological parameters. The aim was to address the shortcomings of standard scale-up methodologies and provide a framework for fermenter scale-up that enables the accurate estimation of energy consumption by suitable selection of turbine and speed for industrial deployment. Moreover, life cycle assessment (LCA) was carried out to identify the potential impacts and possibilities to reduce the operation associated emissions at an early stage. The findings showed that a 3000 times scale-up strategy assuming constant geometric dimensions and specific energy consumption (P/Vw) resulted in lower impeller speed and energy demand. The Rushton turbine blade (RTB) and LightninA315 four-blade hydrofoil (LA315) were found to have the highest and lowest torque output, respectively, at a similar P/Vw of 2.8 kWm−3, with agitation speeds of 1.33 and 2.5 s−1, respectively. RTB demonstrating lower shear damage towards cells (up to 1.33 s−1) was selected because it permits high torque, low-power and acceptable turbulence. The LCA results showed a strong relation between the number of impellers installed and associated emissions suggesting a trade-off between mixing performance and environmental impacts.

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