Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon

2011 ◽  
Vol 236 (9) ◽  
pp. 1005-1011 ◽  
Author(s):  
Khalid S Al-Numair ◽  
Mostafa I Waly ◽  
Amanat Ali ◽  
Mohamed M Essa ◽  
Mohamed F Farhat ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aberrant Crypt Foci ◽  
Rat Colon ◽  
Dietary Folate ◽  
And Oxidative Stress

Styrax camporum, a typical species of the Brazilian cerrado, attenuates DNA damage, preneoplastic lesions and oxidative stress in experimental rat colon carcinogenesis

2021 ◽  
pp. 1-11
Author(s):  
Pollyanna Francielli De Oliveira ◽  
Luis Fernando Leandro ◽  
Ricardo Andrade Furtado ◽  
Natália Helen Ferreira ◽  
Patrícia Mendonça Pauletti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Colon Carcinogenesis ◽  
Rat Colon ◽  
Brazilian Cerrado ◽  
Preneoplastic Lesions ◽  
Typical Species ◽  
And Oxidative Stress

scholarly journals Annona crassiflora Mart. fruit pulp effects on biochemical parameters and rat colon carcinogenesis

2013 ◽  
Vol 37 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Vinícius Paula Venâncio ◽  
Eric Batista Ferreira ◽  
Maísa Ribeiro Pereira Lima Brigagão ◽  
Fernanda Borges de Araújo Paula ◽  
Luis Fernando Barbisan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cellular Localization ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Colon Carcinogenesis ◽  
Aberrant Crypt Foci ◽  
Nuclear Antigen ◽  
Rat Colon ◽  
Commercial Diet

A. crassiflora Mart. a Brazilian savannah fruit, is a source of phytochemical compounds that possess a wide array of biological activities, including free radical scavenging. This native fruit proved to potentialize the mutagenic process in previous in vivo investigations. The aim of the present study was to investigate the effects of A. crassiflora Mart. pulp intake on colonic cell proliferation and on the development of Aberrant Crypt Foci (ACF) in male Wistar rats. The animals were fed with either a commercial diet or a diet supplemented with A. crassiflora Mart. pulp mixed in 1%, 10% or 20% (w/w) for 4 weeks or 20 weeks. The carcinogen 1,2-dimethylhydrazine dihydrochloride (4 doses, 40 mg kg-1 each) was used to induce colonic ACF. After euthanasia, the blood, liver and colon samples were collected for biochemical determinations, oxidative stress or ACF development analysis, respectively. Immunohistochemical analyses of the colonic mucosa were performed using antibodies against proliferating cell nuclear antigen (PCNA) in normal-appearing colonic crypt and β-catenin in ACF. There was no ACF development in the colon from groups treated with A. crassiflora Mart. pulp. Also, the biochemical and oxidative stress analysis, PCNA labeling and ACF development (number, multiplicity or cellular localization of β-catenin) were unchanged as a result of marolo pulp intake. Thus, the present results suggest that A. crassiflora Mart. pulp intake did not exert any protective effect in the colon carcinogenesis induced by DMH in rats.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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