scholarly journals Effect of Muscarinic Receptor Modulators in the Hypothalamic Supraoptic Nucleus of the Rat

1994 ◽  
Vol 66 (4) ◽  
pp. 413-419 ◽  
Author(s):  
Mayumi Mori ◽  
Hiromi Tsushima ◽  
Toshio Kamiya ◽  
Tomohiro Matsuda
Keyword(s):  
Muscarinic Receptor ◽  
Supraoptic Nucleus ◽  
Receptor Modulators ◽  
Hypothalamic Supraoptic Nucleus

EFFECTS OF CHEMORECEPTOR AND BARORECEPTOR STIMULATION ON THE DISCHARGE OF HYPOTHALAMIC SUPRAOPTIC NEURONES IN RATS

1979 ◽  
Vol 82 (1) ◽  
pp. 115-125 ◽  
Author(s):  
M. C. HARRIS
Keyword(s):  
Supraoptic Nucleus ◽  
Carotid Sinus ◽  
Carotid Bifurcation ◽  
Cardiovascular Reflexes ◽  
Nacl Solution ◽  
Baroreceptor Stimulation ◽  
Vasopressin Secretion ◽  
Carotid Body Chemoreceptors ◽  
Hypothalamic Supraoptic Nucleus ◽  
Slight Inhibition

SUMMARY Experiments have been performed to examine the effects of activating the carotid body chemoreceptors and the arterial baroreceptors on the discharge of neurones within the hypothalamic supraoptic nucleus of the rat. Chemoreceptors were activated by intracarotid injection of 0·9% NaCl solution equilibrated with 100% CO2. The baroreceptors of the carotid sinus and aortic arch were activated by raising the blood pressure with an intravenous injection of phenylephrine. Chemoreceptor stimulation activated and baroreceptor stimulation inhibited the discharge of all the phasically discharging neurones tested. Neither stimulus had any consistent effect on non-phasically discharging neurones, although slight inhibition occasionally occurred. Anaesthesia of the carotid bifurcation abolished the effects of cardiovascular stimulation on the supraoptic neurones. Responses resumed when the anaesthesia wore off. However, the anaesthesia also seemed to alter the phasic pattern of discharge. The results are discussed with reference to the influence of the cardiovascular receptors upon the neurones in the supraoptic nucleus, and with reference to possible roles for the cardiovascular reflexes in control of vasopressin secretion.

Discovery of Novel Muscarinic Receptor Modulators by Integrating a Natural Product Framework and a Bioactive Molecule

ChemMedChem ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. 384-395 ◽  
Author(s):  
Rajesh Varkhedkar ◽  
Shalini Dogra ◽  
Divya Tiwari ◽  
Yusuf Hussain ◽  
Prem Narayan Yadav ◽  
...  
Keyword(s):  
Natural Product ◽  
Muscarinic Receptor ◽  
Bioactive Molecule ◽  
Receptor Modulators

Urocortin 1 administered into the hypothalamic supraoptic nucleus inhibits food intake in freely fed and food-deprived rats

Amino Acids ◽  
2012 ◽  
Vol 44 (3) ◽  
pp. 879-885 ◽  
Author(s):  
A. Fatima ◽  
S. Andrabi ◽  
G. Wolf ◽  
M. Engelmann ◽  
M. G. Spina
Keyword(s):  
Food Intake ◽  
Supraoptic Nucleus ◽  
Urocortin 1 ◽  
Hypothalamic Supraoptic Nucleus
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