Augmented energy consumption during early systole as a mechanism of cyclical changes in high-energy phosphates in myocardium assessed by phosphorus nuclear magnetic resonance.

1985 ◽  
Vol 49 (10) ◽  
pp. 1099-1107 ◽  
Author(s):  
HIDEO KUSUOKA ◽  
MICHITOSHI INOUE ◽  
YUTAKA TSUNEOKA ◽  
HIROSHI WATARI ◽  
MASATSUGU HORI ◽  
...  
1988 ◽  
Vol 8 (6) ◽  
pp. 816-821 ◽  
Author(s):  
Kathryn Allen ◽  
Albert L. Busza ◽  
H. Alan Crockard ◽  
Richard S. J. Frackowiak ◽  
David G. Gadian ◽  
...  

CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. At the same time, intracellular pH and the concentrations of lactate and high-energy phosphates were measured in the brain using 1H and 31P nuclear magnetic resonance spectroscopy. Flow and metabolism have been followed during either a 15- or a 30-min ischaemic period (induced by bilateral carotid occlusion) and for up to 1 h of recovery. There was no significant difference between the flow characteristics of the two experimental groups. High-energy phosphate levels and pH returned to control within ∼20 min of the end of the ischaemic period. Lactate clearance, following a 30-min occlusion, was slower than the recovery of pH. The concentration of free ADP, calculated from the creatine kinase equilibrium, was lower during the recovery phase than under control conditions.


1994 ◽  
Vol 7 (7) ◽  
pp. 319-326 ◽  
Author(s):  
Geert A. H. J. Smits ◽  
Erik B. Cornel ◽  
Erik van de Boogert ◽  
Gosse O. N. Oosterhof ◽  
Frans M. J. Debruyne ◽  
...  

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