Experimental Studies on the Clearance of Indocyanine Green from the Blood : Symposium on Methods for the Study of Hepatic Circulation; Hepatic Circulatory Disturbances in Liver Diseases

1964 ◽  
Vol 28 (1) ◽  
pp. 19-21
Author(s):  
SADAKICHI HIROSE ◽  
HIRONAKA KAWASAKI ◽  
CHISATO HIRAYAMA ◽  
TOMIICHI MASUYA
Keyword(s):  
Indocyanine Green ◽  
Liver Diseases ◽  
Experimental Studies ◽  
Hepatic Circulation ◽  
Circulatory Disturbances

General anesthesia and hepatic circulation

1987 ◽  
Vol 65 (8) ◽  
pp. 1762-1779 ◽  
Author(s):  
Simon Gelman
Keyword(s):  
Blood Flow ◽  
General Anesthesia ◽  
Surgical Procedures ◽  
Hepatic Blood Flow ◽  
Portal Blood Flow ◽  
Arterial Blood Flow ◽  
Hepatic Circulation ◽  
Arterial Blood ◽  
Total Hepatic Blood Flow ◽  
Circulatory Disturbances

This article describes hepatic circulatory disturbances associated with anesthesia and surgical intervention. The material is presented in three parts: part 1 describes the effects of general anesthetics on the hepatic circulation; part 2 deals with different factors related to surgical procedures and anesthesia; and part 3 analyzes the role of hepatic circulatory disturbances and hepatic oxygen deprivation in anesthesia-induced hepatotoxicity. The analysis of available data suggests that general anesthesia affects the splanchnic and hepatic circulation in various directions and to different degrees. The majority of anesthetics decreases portal blood flow in association with a decrease in cardiac output. However, hepatic arterial blood flow can be preserved, decreased, or increased. The increase in hepatic arterial blood flow, when it occurs, is usually not enough to compensate for a decrease in portal blood flow and therefore total hepatic blood flow is usually decreased during anesthesia. This decrease in total hepatic blood flow-has certain pharmacokinetic implications, namely a decrease in clearance of endogenous and exogenous substances with a high hepatic extraction ratio. On the other hand, a reduction in the hepatic oxygen supply might play a certain role in liver dysfunction occurring perioperatively. Surgical procedures–preparations combined with anesthesia have a very complex effect on the splanchnic and hepatic circulation. Within this complex, the surgical procedure–preparation plays the main role in developing circulatory disturbances, while anesthesia plays only a modifying role. Hepatic oxygen deprivation may play an important role in anesthesia-induced hepatotoxicity in different experimental models.

Hepatic clearances of antipyrine, indocyanine green, and galactose in normal subjects and in patients with chronic liver diseases

1988 ◽  
Vol 44 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Seiji Kawasaki ◽  
Yuichi Sugiyama ◽  
Tatsuji Iga ◽  
Manabu Hanano ◽  
Tomoe Beppu ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Liver Diseases ◽  
Normal Subjects ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals 64. Experimental Studies on Hepatic Circulation and Functions in Head Injury

1963 ◽  
Vol 5 (0) ◽  
pp. 93b-94
Author(s):  
Nobuo MORIYASU ◽  
Kohten SATOW ◽  
Torao FUJII ◽  
Masakazu HONMA ◽  
Fumio MIYAUCHI ◽  
...  
Keyword(s):  
Head Injury ◽  
Experimental Studies ◽  
Hepatic Circulation
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