scholarly journals Measurement of Blood Flow in Intra- and Extra-hepatic Shunt : Symposium on Methods for the Study of Hepatic Circulation; Hepatic Circulatory Disturbances in Liver Diseases

1964 ◽  
Vol 28 (1) ◽  
pp. 13-17
Author(s):  
SHOZO NAKAMURA
Keyword(s):  
Blood Flow ◽  
Liver Diseases ◽  
Hepatic Circulation ◽  
Circulatory Disturbances

General anesthesia and hepatic circulation

1987 ◽  
Vol 65 (8) ◽  
pp. 1762-1779 ◽  
Author(s):  
Simon Gelman
Keyword(s):  
Blood Flow ◽  
General Anesthesia ◽  
Surgical Procedures ◽  
Hepatic Blood Flow ◽  
Portal Blood Flow ◽  
Arterial Blood Flow ◽  
Hepatic Circulation ◽  
Arterial Blood ◽  
Total Hepatic Blood Flow ◽  
Circulatory Disturbances

This article describes hepatic circulatory disturbances associated with anesthesia and surgical intervention. The material is presented in three parts: part 1 describes the effects of general anesthetics on the hepatic circulation; part 2 deals with different factors related to surgical procedures and anesthesia; and part 3 analyzes the role of hepatic circulatory disturbances and hepatic oxygen deprivation in anesthesia-induced hepatotoxicity. The analysis of available data suggests that general anesthesia affects the splanchnic and hepatic circulation in various directions and to different degrees. The majority of anesthetics decreases portal blood flow in association with a decrease in cardiac output. However, hepatic arterial blood flow can be preserved, decreased, or increased. The increase in hepatic arterial blood flow, when it occurs, is usually not enough to compensate for a decrease in portal blood flow and therefore total hepatic blood flow is usually decreased during anesthesia. This decrease in total hepatic blood flow-has certain pharmacokinetic implications, namely a decrease in clearance of endogenous and exogenous substances with a high hepatic extraction ratio. On the other hand, a reduction in the hepatic oxygen supply might play a certain role in liver dysfunction occurring perioperatively. Surgical procedures–preparations combined with anesthesia have a very complex effect on the splanchnic and hepatic circulation. Within this complex, the surgical procedure–preparation plays the main role in developing circulatory disturbances, while anesthesia plays only a modifying role. Hepatic oxygen deprivation may play an important role in anesthesia-induced hepatotoxicity in different experimental models.

Influence of sodium pentobarbital on splanchnic blood flow and related functions

1959 ◽  
Vol 197 (3) ◽  
pp. 624-626 ◽  
Author(s):  
Ann Evringham ◽  
Edith M. Brenneman ◽  
Steven M. Horvath
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Intravenous Injection ◽  
Anesthetic Agent ◽  
Splanchnic Blood Flow ◽  
Sodium Pentobarbital ◽  
Hepatic Circulation ◽  
Blood Flows

Eleven mongrel dogs were trained to lie quietly while splanchnic blood flows and splanchnic metabolisms were determined. They were then anesthetized by means of intravenous injection of 28.4 mg/kg of sodium pentobarbital and studies of the hepatic circulation continued for an additional 70 minutes. Only minor, transitory alterations were observed in the parameters being measured. It was concluded that with this particular anesthetic agent splanchnic blood flows and oxygen consumption were essentially at control unanesthetized levels within 30–45 minutes postanesthesia.

Dose-Dependent Effects of Meclofenamate on Peripheral Vasculature of Conscious Rabbits

1983 ◽  
Vol 64 (5) ◽  
pp. 471-474 ◽  
Author(s):  
R. A. Banks ◽  
L. J. Beilin ◽  
J. Soltys
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Organ Blood Flow ◽  
Hepatic Circulation ◽  
Peripheral Vasculature ◽  
Conscious Rabbits ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
The Brain ◽  
Intravenous Sodium

1. Changes in systemic haemodynamics and organ blood flow were measured in conscious rabbits after various doses of intravenous sodium meclofenamate, an inhibitor of prostaglandin cyclo-oxygenase. 2. Meclofenamate had no effect on arterial pressure or cardiac output but caused a dose-dependent fall in renal blood flow. 3. Meclofenamate also reduced adrenal perfusion but, in contrast, caused a dose-dependent increase in blood flow to the brain, bronchial and hepatic circulation and to the testis. No effect was demonstrated on other organs studied. 4. The effect on the cerebral circulation was observed at the lowest dose of meclofenamate (0.75 mg/kg). Higher total doses were necessary for an effect on the renal and bronchial (3 mg/kg) and testicular and hepatic arteries (6 mg/kg). 5. The results suggest a variety of local vasomotor influences of renal and non-renal prostaglandins in conscious rabbits.

scholarly journals Effect of histamine H2-receptor antagonists on the total hepatic blood flow in patients with chronic liver diseases.

Kanzo ◽  
1986 ◽  
Vol 27 (7) ◽  
pp. 908-914 ◽  
Author(s):  
Kouichi AKAMATSU ◽  
Souichiro MIYAUCHI ◽  
Kenya MURASE ◽  
Yuji WATANABE ◽  
Nobuo NISHIMURA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Total Hepatic Blood Flow
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