scholarly journals Hemodynamic Analysis on the Liver in Portal Hypertension : Symposium on Methods for the Study of Hepatic Circulation; Hepatic Circulatory Disturbances in Liver Diseases

1964 ◽  
Vol 28 (1) ◽  
pp. 17-19
Author(s):  
YASUO KUROYANAGI ◽  
YASUHISA YOKOYAMA
Keyword(s):  
Portal Hypertension ◽  
Liver Diseases ◽  
Hepatic Circulation ◽  
Circulatory Disturbances

General anesthesia and hepatic circulation

1987 ◽  
Vol 65 (8) ◽  
pp. 1762-1779 ◽  
Author(s):  
Simon Gelman
Keyword(s):  
Blood Flow ◽  
General Anesthesia ◽  
Surgical Procedures ◽  
Hepatic Blood Flow ◽  
Portal Blood Flow ◽  
Arterial Blood Flow ◽  
Hepatic Circulation ◽  
Arterial Blood ◽  
Total Hepatic Blood Flow ◽  
Circulatory Disturbances

This article describes hepatic circulatory disturbances associated with anesthesia and surgical intervention. The material is presented in three parts: part 1 describes the effects of general anesthetics on the hepatic circulation; part 2 deals with different factors related to surgical procedures and anesthesia; and part 3 analyzes the role of hepatic circulatory disturbances and hepatic oxygen deprivation in anesthesia-induced hepatotoxicity. The analysis of available data suggests that general anesthesia affects the splanchnic and hepatic circulation in various directions and to different degrees. The majority of anesthetics decreases portal blood flow in association with a decrease in cardiac output. However, hepatic arterial blood flow can be preserved, decreased, or increased. The increase in hepatic arterial blood flow, when it occurs, is usually not enough to compensate for a decrease in portal blood flow and therefore total hepatic blood flow is usually decreased during anesthesia. This decrease in total hepatic blood flow-has certain pharmacokinetic implications, namely a decrease in clearance of endogenous and exogenous substances with a high hepatic extraction ratio. On the other hand, a reduction in the hepatic oxygen supply might play a certain role in liver dysfunction occurring perioperatively. Surgical procedures–preparations combined with anesthesia have a very complex effect on the splanchnic and hepatic circulation. Within this complex, the surgical procedure–preparation plays the main role in developing circulatory disturbances, while anesthesia plays only a modifying role. Hepatic oxygen deprivation may play an important role in anesthesia-induced hepatotoxicity in different experimental models.

Hepatic Circulation and Portal Hypertension

1973 ◽  
Vol 53 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Willem tenHove ◽  
Carroll M. Leevy
Keyword(s):  
Portal Hypertension ◽  
Hepatic Circulation

Liver disorders

2016 ◽  
Author(s):  
Chris Verslype ◽  
David Cassiman ◽  
Johan Verhaeghe
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Liver Failure ◽  
Liver Diseases ◽  
Systematic Approach ◽  
Liver Disorders ◽  
Diagnostic Characteristics ◽  
Mother And Child ◽  
Prognostic Implications ◽  
In Pregnancy

Liver disease can complicate 5% of pregnancies, putting mother and child at risk for increased morbidity and mortality. Cholestasis, portal hypertension, and liver failure represent three major clinical entities that should be recognized early because of the prognostic implications. Liver disease in pregnancy is generally separated into disorders that are unique to pregnancy and those that coincide with pregnancy. This chapter recommends a systematic approach that focuses on the major differential diagnostic characteristics of pregnancy-related liver diseases and a limited set of tests for pregnancy-unrelated liver diseases. Management of these conditions should be performed by a multidisciplinary team and ranges from simple medical therapies to immediate termination of the pregnancy.

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