scholarly journals In Normoglycemic Koreans, Insulin Resistance and Adipocity are Independently Correlated With High Blood Pressure

2004 ◽  
Vol 68 (10) ◽  
pp. 898-902 ◽  
Author(s):  
Ki Chul Sung ◽  
Byung Jin Kim ◽  
Bum Su Kim ◽  
Jin Ho Kang ◽  
Man Ho Lee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
High Blood Pressure

Abstract P051: Inflammation is Significantly Associated With High Blood Pressure in Females Only

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jenny Eckner ◽  
Charlotte A Larsson ◽  
Lennart Rastam ◽  
Ulf Lindblad
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Weight ◽  
Linear Regression ◽  
High Blood Pressure ◽  
Statistical Analyses ◽  
Interaction Terms ◽  
Relative Body Weight ◽  
Males And Females ◽  
Hs Crp

INTRODUCTION The causes of high blood pressure are complex and based on an interaction between multiple biological factors and behaviours. Insulin resistance and inflammation are commonly acknowledged mechanisms in the development of CVD, while insulin resistance and relative body weight correspondingly predict the development of high blood pressure. HYPOTHESIS We aimed to compare insulin resistance, relative body weight, and inflammation in the association with SBP. METHODS In 2001-2005 a random sample of residents aged 30-74 years in the municipalities of Vara and Skövde, South-western Sweden, were invited to a survey of cardiovascular risk factors. In all 1811 participants in Vara (participation rate 81%) and 1005 participants in Skövde (70%) were enrolled. Subjects with a known history of hypertension were excluded for the current study. Specially trained nurses saw all subjects in the morning after a 10 hours over night fast, and venous blood samples were taken. A physical examination included body height and body weight (light cloths and no shoes), blood pressure was measured twice in a supine position after a 5 minutes rest (arm in heart level). The mean of the 2 measurements was used for statistical analyses. Hs-CRP and plasma insulin were analysed, and BMI and HOMA-index were calculated using standard algorithms. The log form of HOMA-ir was used in statistical analyses. Associations were explored in males and females separately using multivariate linear regression. RESULTS In all 2538 subjects, 1266 men (50%) and 1272 women (50%) without known hypertension were included. BMI and HOMA-ir were both significantly associated with SBP in both males and females, while hs-CRP was associated with SBP in women only. These factors were accordingly entered into a multivariate linear regression model also including age. In men HOMA-ir [regression coefficient, (95% confidence interval), and p-value] [5.4 (2.5-8.4), p<0.001], was significantly associated with SBP, while BMI [0.2 (-0.3-0.5), p=0.087], and CRP was not [0.02 (-0.1-0.1), p=0.138]. In women all three mechanisms came out significantly; HOMA-ir [5.4 (2.2-8.6), p<0.001], BMI [0.4 (0.2-0.5), p<0.001], and CRP [0.2 (0.02-0.4), p=0.031]. There were statistically significant interaction terms between gender and CRP (p=0.037), and gender and HOMA-ir (P=0.045), respectively, while no corresponding interaction was found for BMI. CONCLUSIONS Our study confirms a strong impact of insulin resistance and relative body weight on blood pressure levels in both men and women. However, a significant association between hs-CRP and systolic blood pressure in women was not seen in men. Gender differences in insulin resistance and inflammation were statistically confirmed by interaction terms. These findings have implications for future research and for development of clinical practice.

High blood pressure and insulin resistance: influence of ethnic background

1991 ◽  
Vol 21 (3) ◽  
pp. 280-287 ◽  
Author(s):  
E. FERRANNINI ◽  
S.M. HAFFNER ◽  
M.P. STERN ◽  
B.D. MITCHELL ◽  
A. NATALI ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Ethnic Background

scholarly journals Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure

2008 ◽  
Vol 81 (2) ◽  
pp. 231-237 ◽  
Author(s):  
Jennifer L. Kimbell ◽  
Tanya A. Koropatnick ◽  
John S. Grove ◽  
Yung-Hsiang Huang ◽  
Fu-Tien Chiang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Asian Population ◽  
Gene Variants ◽  
Absence Of Evidence

scholarly journals High Blood Pressure, Bone-Mineral Loss and Insulin Resistance in Women

2005 ◽  
Vol 28 (7) ◽  
pp. 565-570 ◽  
Author(s):  
Mitsuhiro GOTOH ◽  
Kenji MIZUNO ◽  
Yoshiaki ONO ◽  
Michihiko TAKAHASHI
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Bone Mineral ◽  
Bone Mineral Loss ◽  
Mineral Loss

Abstract P398: Uric Acid And Prehypertension: Salt Intake in Addition to Insulin Resistance are not Mediators.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Paulo A Lotufo ◽  
Itamar S Santos ◽  
Isabela M Bensenor
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Body Mass ◽  
High Blood Pressure ◽  
Urinary Sodium ◽  
Full Model

Introduction: The association "uric acid and high blood pressure" is still matter of debate. Therefore, to distinguish serum uric acid as an independent factor for high blood pressure can start new trials to prevent hypertension. A paleoantropological rationale for this association was a knockout of uricase occurred during the Miocene among hominids that induced high levels of uric acid. As consequence, during food shortage times, high uric acid had an evolutionary benefit increasing salt-sensitivity for keep blood pressure and rising insulin resistance that maintaining high blood glucose levels provided fuel for the brain. Nowadays, the average levels of uric acid are substantially higher compared to chimpanzees, a uricase-deficient primate, and among remote populations as the yanomamo. Hypothesis: we assessed the hypothesis that the link between uric acid and blood pressure in individuals without hypertension is independent of sex, age, race, salt and alcohol intakes, glucose homeostasis, body-mass index and renal function. Methods: from the 15105 participants of the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) aged 35-74 years, we selected 7954 individuals (median age = 48 years-old; women =58.1; White = 56.6%) without hypertension, diabetes, previous cardiovascular diseases. The presence or not of prehypertension (7th JNC criteria) was the dependent variable and quartiles (Q) of serum uric acid, the independent variable. We applied an unconditional logistic regression adjusted for age and sex. After this, according to our hypothesis, we added the following variables: (1) 24-hour urinary sodium; (2) log Homeostasis Model Assessment (fasting blood glucose (mg/dL) х fasting insulin (mg/dL)/450), and (3) a full model, adding race, body-mass index, alcohol intake, and glomerular filtration rate by CKD-epi). Results: the uric acid quartiles ranges (md/dL) were Q1 ≤ 4.1; Q2:4.2-5.0; Q3:5.1-6.0; Q4: ≥ 6.1 and the number of participants were Q1= 1909; Q2=2029; Q3=2000; Q4= 2016. Considering Q1 as reference, the age-sex adjusted odds ratios (95% Confidence Interval) through the quartiles were: Q2= 1.22 (1.05-1.41); Q3= 1.40 (1.20-1.63); Q4= 2.03 (1.71-2.39) [P for trend <0.001]. Adding 24 hour urinary sodium, the ORs (95% CI) were: Q2= 1.19 (1.01-1.40); Q3= 1.37 (1.16-1.62); and 1.94 (1.61-2.33) [P for trend <0.001]. Adding HOMA-IR, the ORs (95% CI) were: Q2= 1.14 (0.97-1.34); Q3= 1.25(1.05-1.48); and Q4=1.62(1.34-1.96) [P for trend <0.001]. Finally, for the full model the ORs were Q2= 1.04 (0.88-1.23); Q3= 1.05 (0.88-1.26) and Q4= 1.32(1.08-1.62) [P for trend <0. 01]. Conclusion: Uric acid levels were correlated to prehypertension among a middle-aged urban population. It occurred independently of other variables classically associated to high blood pressure or the origin of higher uric acid in hominids.

scholarly journals Effects of recommendations to follow the Dietary Approaches to Stop Hypertension (DASH) diet v. usual dietary advice on childhood metabolic syndrome: a randomised cross-over clinical trial

2013 ◽  
Vol 110 (12) ◽  
pp. 2250-2259 ◽  
Author(s):  
Parvane Saneei ◽  
Mahin Hashemipour ◽  
Roya Kelishadi ◽  
Somayeh Rajaei ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Clinical Trial ◽  
Waist Circumference ◽  
Vitamin C ◽  
High Blood Pressure ◽  
Adolescent Girls ◽  
Dietary Advice ◽  
Dash Diet

The effects of the Dietary Approaches to Stop Hypertension (DASH) eating plan on childhood metabolic syndrome (MetS) and insulin resistance remain to be determined. The present study aimed to assess the effects of recommendations to follow the DASH diet v. usual dietary advice (UDA) on the MetS and its features in adolescents. In this randomised cross-over clinical trial, sixty post-pubescent adolescent girls with the MetS were randomly assigned to receive either the recommendations to follow the DASH diet or UDA for 6 weeks. After a 4-week washout period, the participants were crossed over to the alternate arm. The DASH group was recommended to consume a diet rich in fruits, vegetables and low-fat dairy products and low in saturated fats, total fats and cholesterol. UDA consisted of general oral advice and written information about healthy food choices based on healthy MyPlate. Compliance was assessed through the quantification of plasma vitamin C levels. In both the groups, fasting venous blood samples were obtained at baseline and at the end of each phase of the intervention. The mean age and weight of the participants were 14·2 (sd 1·7) years and 69 (sd 14·5) kg, respectively. Their mean BMI and waist circumference were 27·3 kg/m2 and 85·6 cm, respectively. Serum vitamin C levels tended to be higher in the DASH phase than in the UDA phase (860 (se 104) v. 663 (se 76) ng/l, respectively, P= 0·06). Changes in weight, waist circumference and BMI were not significantly different between the two intervention phases. Although changes in systolic blood pressure were not statistically significant between the two groups (P= 0·13), recommendations to follow the DASH diet prevented the increase in diastolic blood pressure compared with UDA (P= 0·01). We found a significant within-group decrease in serum insulin levels (101·4 (se 6·2) v. 90·0 (se 5·5) pmol/l, respectively, P= 0·04) and a non-significant reduction in the homeostasis model assessment for insulin resistance score (P= 0·12) in the DASH group. Compared with the UDA group, the DASH group experienced a significant reduction in the prevalence of the MetS and high blood pressure. Recommendations to follow the DASH eating pattern for 6 weeks among adolescent girls with the MetS led to reduced prevalence of high blood pressure and the MetS and improved diet quality compared with UDA. This type of healthy diet can be considered as a treatment modality for the MetS and its components in children.

Insulin Resistance and Abnormal Electrocardiograms in Patients With High Blood Pressure

1992 ◽  
Vol 5 (7) ◽  
pp. 444-448 ◽  
Author(s):  
Wayne H.-H. Sheu ◽  
Chii-Y. Jeng ◽  
Shyh-M. Shieh ◽  
Martin M.-T. Fuh ◽  
David D.-C. Shen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
High Blood Pressure
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