scholarly journals High Blood Pressure, Bone-Mineral Loss and Insulin Resistance in Women

2005 ◽  
Vol 28 (7) ◽  
pp. 565-570 ◽  
Author(s):  
Mitsuhiro GOTOH ◽  
Kenji MIZUNO ◽  
Yoshiaki ONO ◽  
Michihiko TAKAHASHI
2000 ◽  
Vol 55 (2) ◽  
pp. 98
Author(s):  
Francesco P. Cappuccio ◽  
Elaine Meilahn ◽  
Joseph M. Zmuda ◽  
Jane A. Cauley

The Lancet ◽  
1999 ◽  
Vol 354 (9183) ◽  
pp. 971-975 ◽  
Author(s):  
Francesco P Cappuccio ◽  
Elaine Meilahn ◽  
Joseph M Zmuda ◽  
Jane A Cauley

PM&R ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. S155
Author(s):  
Belgin Erhan ◽  
Ebru Yilmaz Yalcinkaya ◽  
Berrin Gunduz ◽  
Hulya Aslan ◽  
Fatih Kahraman

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jenny Eckner ◽  
Charlotte A Larsson ◽  
Lennart Rastam ◽  
Ulf Lindblad

INTRODUCTION The causes of high blood pressure are complex and based on an interaction between multiple biological factors and behaviours. Insulin resistance and inflammation are commonly acknowledged mechanisms in the development of CVD, while insulin resistance and relative body weight correspondingly predict the development of high blood pressure. HYPOTHESIS We aimed to compare insulin resistance, relative body weight, and inflammation in the association with SBP. METHODS In 2001-2005 a random sample of residents aged 30-74 years in the municipalities of Vara and Skövde, South-western Sweden, were invited to a survey of cardiovascular risk factors. In all 1811 participants in Vara (participation rate 81%) and 1005 participants in Skövde (70%) were enrolled. Subjects with a known history of hypertension were excluded for the current study. Specially trained nurses saw all subjects in the morning after a 10 hours over night fast, and venous blood samples were taken. A physical examination included body height and body weight (light cloths and no shoes), blood pressure was measured twice in a supine position after a 5 minutes rest (arm in heart level). The mean of the 2 measurements was used for statistical analyses. Hs-CRP and plasma insulin were analysed, and BMI and HOMA-index were calculated using standard algorithms. The log form of HOMA-ir was used in statistical analyses. Associations were explored in males and females separately using multivariate linear regression. RESULTS In all 2538 subjects, 1266 men (50%) and 1272 women (50%) without known hypertension were included. BMI and HOMA-ir were both significantly associated with SBP in both males and females, while hs-CRP was associated with SBP in women only. These factors were accordingly entered into a multivariate linear regression model also including age. In men HOMA-ir [regression coefficient, (95% confidence interval), and p-value] [5.4 (2.5-8.4), p<0.001], was significantly associated with SBP, while BMI [0.2 (-0.3-0.5), p=0.087], and CRP was not [0.02 (-0.1-0.1), p=0.138]. In women all three mechanisms came out significantly; HOMA-ir [5.4 (2.2-8.6), p<0.001], BMI [0.4 (0.2-0.5), p<0.001], and CRP [0.2 (0.02-0.4), p=0.031]. There were statistically significant interaction terms between gender and CRP (p=0.037), and gender and HOMA-ir (P=0.045), respectively, while no corresponding interaction was found for BMI. CONCLUSIONS Our study confirms a strong impact of insulin resistance and relative body weight on blood pressure levels in both men and women. However, a significant association between hs-CRP and systolic blood pressure in women was not seen in men. Gender differences in insulin resistance and inflammation were statistically confirmed by interaction terms. These findings have implications for future research and for development of clinical practice.


Author(s):  
Saba Shamim ◽  
Manju Lal ◽  
Rana Shamim

Background: Osteoporosis is considered as a major public health issue with fragility fractures of the hip, vertebrae and distal radius being the most important consequences. It has been said to be an age-related degenerative process. However, postmenopausal women develop this disease due to age-related bone mineral loss as well as due to declining levels of estrogen in the body following menopause leading to increased risk of fractures. Objectives of this study were to find out the prevalence of osteoporosis in hysterectomised and non-hysterectomised postmenopausal women in 7th decade of life.Methods: Descriptive cross-sectional study done on a total of 66 postmenopausal women who were in their 7th decade of life. They were divided into two groups, one consisting of 36 women who underwent natural menopause and the other group of 30 women who had surgical menopause. The bone mineral density of both the groups was measured using DEXA scan and comparison was done between these study groups.Results: Out of 30 hysterectomised subjects, 24 (80%) were found to be having osteoporosis, 6 (20%) had osteopenia and none had normal BMD. While out of 36 subjects in the non-hysterectomised group, 14 (38.88%) had osteoporosis, 16 (44.44%) had osteopenia and 6 (16.66%) subjects had normal BMD. Significant relation (p-value 0.001) was found on comparison of the study groups. In addition, significant positive correlation was between BMD and BMI whereas negative correlation was seen between BMD and parity.Conclusions: Hysterectomy was found to increase the incidence of osteoporosis. Obesity was found to have protective effect against bone mineral loss while increasing parity had a negative relation with BMD.


Medicine ◽  
2018 ◽  
Vol 97 (41) ◽  
pp. e12755 ◽  
Author(s):  
Hyun Goo Kang ◽  
Hyun Young Park ◽  
Han Uk Ryu ◽  
Seung-Han Suk

1992 ◽  
Vol 39 (2) ◽  
pp. 155-155
Author(s):  
C Di Carlo ◽  
Z Shoham ◽  
J MacDougall ◽  
A Patel ◽  
ML Hall ◽  
...  

1992 ◽  
Vol 19 ◽  
pp. S49-S56 ◽  
Author(s):  
G.B. Melis ◽  
A.M. Paoletti ◽  
R. Bartolini ◽  
M. Tosti Balducci ◽  
G.B. Massi ◽  
...  

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