scholarly journals Effects of Vitamin B12 and Folic Acid on Hyperhomocysteinemia in Patients with Acute Myocardial Infarction

2007 ◽  
Vol 53 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Mohamad Khakid Nusier ◽  
Qasim Abdel El-Dwairi
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Vitamin B12

scholarly journals EVALUATION OF SERUM VITAMIN B12 AND FOLIC ACID IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AMONG SUDANESE’S PATIENT’S

2021 ◽  
Vol 10 (1) ◽  
pp. 88-92
Author(s):  
Mohammed Bilal. A. Bilal ◽  
Tarig.A.M. Hamid ◽  
Makaawi A. Gadir ◽  
Mihad.M. Mahmoud
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Venous Blood ◽  
Serum Vitamin ◽  
High Rate ◽  
Potential Association ◽  
Artery Disease ◽  
Control Study

The Sudanese population has high rate of coronary artery disease (CAD). The potential association between deficiency of vitamin B12 and folic acid, in patients with acute myocardial infarction (AMI), where investigated previously with conflicted results. A case-control study was carried out involving 60 AMI patients (age 39–87 years; 40 men and 20 women) and 40 normal healthy individuals (age 39–84 years; 20 men and 20 women). Fasting venous blood samples were obtained from patients and controls. Serum was analyzed for vitamin B12 and folic acid using radio assays. The mean concentration of serum B12 and folate in AMI patients were found to be significantly lower than in controls. Vitamin B12 and folate deficiency may be considered as a risk factor for CAD development.

scholarly journals ACUTE MYOCARDIAL INFARCTION WITH VITAMIN B12 DEFICIENCY AND MILD HYPERHOMOCYSTEINEMIA: A CASE REPORT AND REVIEW

2016 ◽  
Vol 9 (6) ◽  
pp. 2
Author(s):  
Bijoy Kumar Panda ◽  
Siddhi Pramod Umarje ◽  
Madhu Bansode
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin B12 ◽  
Antiplatelet Agent ◽  
Vitamin B12 Deficiency ◽  
Vascular Diseases ◽  
Antiplatelet Agents ◽  
Adrenergic Blocker ◽  
B12 Deficiency ◽  
Mild Hyperhomocysteinemia

A 38-year old male was diagnosed with acute myocardial infarction (AMI) without a history of any significant clinical conditions. His subjective complaints and objective findings were clearly suggesting an acute ischemic attack along with vitamin B12 deficiency. While managing him for AMI, serology tests for vitamin B12 revealed low levels along with mild elevation of serum homocysteine level. He was managed with thrombolytic agent, β-adrenergic blocker, aspirin, antiplatelet agents, anticoagulants, statin, vitamin B complex and folic acid supplements. The clinical pharmacist intervened by suggesting discontinuation of Clopidogrel as two antiplatelet agents (Clopidogrel and Ticagrelor) were administered along with an anticoagulant, thereby increasing the risk of bleeding in the patient. Clopidogrel was stopped as Ticagrelor is a better antiplatelet agent when given in combination with low dose aspirin. Also, aspirin dose was reduced to enhance the efficacy of Ticagrelor and provide better secondary prevention for vascular diseases.

Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid

1995 ◽  
Vol 237 (4) ◽  
pp. 381-388 ◽  
Author(s):  
F. LANDGREN ◽  
B. ISRAELSSON ◽  
A. LINDGREN ◽  
B. HULTBERG ◽  
A. ANDERSSON ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Plasma Homocysteine ◽  
Lowering Effect

Effect of Folic Acid on Endothelial Function Following Acute Myocardial Infarction

2007 ◽  
Vol 99 (4) ◽  
pp. 476-481 ◽  
Author(s):  
An L. Moens ◽  
Marc J. Claeys ◽  
Floris L. Wuyts ◽  
Inge Goovaerts ◽  
Els Van Hertbruggen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Endothelial Function

scholarly journals Case report of an acute myocardial infarction after high-dose recreational nitrous oxide use: a consequence of hyperhomocysteinaemia?

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Thomas Oomens ◽  
Robert K Riezebos ◽  
Giovanni Amoroso ◽  
Remko S Kuipers
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
High Dose ◽  
Ventricular Ejection Fraction ◽  
Increased Risk ◽  
Very High

Abstract Background Nitrous oxide (N2O, laughing gas) is increasingly used as a recreational drug and is presumed relatively safe and innocent. It is often being used in combination with other substances, such as cannabis. Case summary A young adult attended the emergency room because of chest pain after recreational use of very high-dose nitrous oxide in combination with cannabis. Electrocardiography demonstrated ST-elevation in the anterior leads. Coronary angiography showed thrombus in the proximal and thrombotic occlusion of the distal left anterior descending coronary artery for which primary percutaneous coronary intervention was attempted. Thrombus aspiration was unsuccessful and the patient was further treated with a glycoprotein IIb/IIIa in addition to dual platelet therapy. Blood results showed low vitamin B12 and folic acid status with concomitant hyperhomocysteinaemia, a known cause of hypercoagulation. Transthoracic echocardiogram showed a moderately reduced left ventricular ejection fraction (LVEF). Three months later, an improvement in LVEF and no recurrent angina or symptoms of heart failure were noticed. Discussion We report a case of acute myocardial infarction secondary to very high-dose nitrous oxide abuse in combination with cannabis and possible hypoxia. We propose that severe hyperhomocysteinaemia secondary to nitrous oxide-induced vitamin B12 deficiency together with the vasoconstrictive effects of cannabis might pose a seriously increased risk for intracoronary, among others, thrombus formation. In conclusion, we contest the safety and innocence of recreational nitrous oxide (ab)use, notably in the context of other factors increasing the risk of coagulation.

scholarly journals Effect of Folic Acid Supplementation on Serum Homocystene and Lipid Profile in Acute Myocardial Infarction

1970 ◽  
Vol 5 (2) ◽  
pp. 21-23
Author(s):  
MA Wahab ◽  
F Zafreen ◽  
MA Siddique ◽  
Y Akter ◽  
Z Parveen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Lipid Profile ◽  
Reference Value ◽  
Folic Acid Supplementation ◽  
Double Blind ◽  
Acid Supplementation ◽  
One Year ◽  
Medical University

This double blind randomized placebo controlled experimental study was carried out at the department of Biochemistry and Cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh over a period of one year. A total number of sixty (60) hospitalized acute myocardial infarction (AMI) patients of both sexes, age ranging 35 to 65 years, agreed after informed written consent, were included in the study. Cases were selected purposively on the basis of specified inclusion and exclusion criteria from hospitalized diagnosed patients of AMI. After detail history, clinical examination, physical and anthropometrics measurements study subjects were randomized into two groups and treated with 5 mg folic acid or placebo for 4 weeks. Fasting serum homocysteine (Hcy) and lipid profile of all the study subjects were estimated both before starting the drug and after completion of treatment, Hcy concentration was estimated by fluorescence polarization immunoassay (FPIA) method in 'AxSYM system' (Abbott, USA). Statistical analyses were done by using 'SPSS 12.0, continuous data were expressed as mean ± SEM and categorical data in percentage (%) and frequency. AMI patients Hcy concentration was higher than normal reference value (5 - 15 mmol/L). Folic acid supplementation decreased serum Hcy concentration very significantly (p<0.001) in drug group (from 25.92 ± 2.47 to 15.38 ± 0.68 mmol/L) but effect in placebo group was found no significant (p>0.05). In this study folic acid supplementation at a dose of 5 mg/day decreased Hcy concentration almost by 27%. Folic acid supplementation significantly (p<0.05) increased HDL concentration but shown no significant effect on other parameter of lipid profiles. Key words: Acute myocardial infarction (AMI), homocystein (Hcy), folic acid (Folate). DOI: 10.3329/jafmc.v5i2.4578 JAFMC Bangladesh Vol.5(2) (December) 2009, pp.21-23

scholarly journals Acute Myocardial Infarction in a Young Lady due to Vitamin B12 Deficiency Induced Hyperhomocysteinemia

Heart Views ◽  
2015 ◽  
Vol 16 (1) ◽  
pp. 25 ◽  
Author(s):  
SunilRoy Narayanan ◽  
AnilKumar Rajappan ◽  
WarkaaAl Shamkani ◽  
NaghamSaeed Jafar
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Young Lady ◽  
B12 Deficiency
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