Hyperhomocysteinemia in a cohort of young patients with acute myocardial infarction from Western India: Pattern of response to oral folic acid, vitamin B12, B6 therapy

2007 ◽  
Vol 377 (1-2) ◽  
pp. 281-282
Author(s):  
Kanjaksha Ghosh ◽  
Amit Khare ◽  
Shrimati Shetty ◽  
Bipin Kulkarni
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Young Patients ◽  
Western India

scholarly journals EVALUATION OF SERUM VITAMIN B12 AND FOLIC ACID IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AMONG SUDANESE’S PATIENT’S

2021 ◽  
Vol 10 (1) ◽  
pp. 88-92
Author(s):  
Mohammed Bilal. A. Bilal ◽  
Tarig.A.M. Hamid ◽  
Makaawi A. Gadir ◽  
Mihad.M. Mahmoud
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Venous Blood ◽  
Serum Vitamin ◽  
High Rate ◽  
Potential Association ◽  
Artery Disease ◽  
Control Study

The Sudanese population has high rate of coronary artery disease (CAD). The potential association between deficiency of vitamin B12 and folic acid, in patients with acute myocardial infarction (AMI), where investigated previously with conflicted results. A case-control study was carried out involving 60 AMI patients (age 39–87 years; 40 men and 20 women) and 40 normal healthy individuals (age 39–84 years; 20 men and 20 women). Fasting venous blood samples were obtained from patients and controls. Serum was analyzed for vitamin B12 and folic acid using radio assays. The mean concentration of serum B12 and folate in AMI patients were found to be significantly lower than in controls. Vitamin B12 and folate deficiency may be considered as a risk factor for CAD development.

C0347 Thrombin binding to platelets of young patients with a history of acute myocardial infarction

2012 ◽  
Vol 130 ◽  
pp. S104
Author(s):  
Grazia Loredana Mendolicchio ◽  
Monica Bacci ◽  
Dennis Zavalloni ◽  
Lidia Rota ◽  
Zaverio Marcello Ruggeri
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Patients ◽  
History Of

Acute myocardial infarction in young patients

2021 ◽  
Vol 79 (10) ◽  
pp. 1093-1098
Author(s):  
Wojciech Zasada ◽  
Beata Bobrowska ◽  
Krzysztof Plens ◽  
Artur Dziewierz ◽  
Zbigniew Siudak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Patients

scholarly journals ACUTE MYOCARDIAL INFARCTION WITH VITAMIN B12 DEFICIENCY AND MILD HYPERHOMOCYSTEINEMIA: A CASE REPORT AND REVIEW

2016 ◽  
Vol 9 (6) ◽  
pp. 2
Author(s):  
Bijoy Kumar Panda ◽  
Siddhi Pramod Umarje ◽  
Madhu Bansode
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin B12 ◽  
Antiplatelet Agent ◽  
Vitamin B12 Deficiency ◽  
Vascular Diseases ◽  
Antiplatelet Agents ◽  
Adrenergic Blocker ◽  
B12 Deficiency ◽  
Mild Hyperhomocysteinemia

A 38-year old male was diagnosed with acute myocardial infarction (AMI) without a history of any significant clinical conditions. His subjective complaints and objective findings were clearly suggesting an acute ischemic attack along with vitamin B12 deficiency. While managing him for AMI, serology tests for vitamin B12 revealed low levels along with mild elevation of serum homocysteine level. He was managed with thrombolytic agent, β-adrenergic blocker, aspirin, antiplatelet agents, anticoagulants, statin, vitamin B complex and folic acid supplements. The clinical pharmacist intervened by suggesting discontinuation of Clopidogrel as two antiplatelet agents (Clopidogrel and Ticagrelor) were administered along with an anticoagulant, thereby increasing the risk of bleeding in the patient. Clopidogrel was stopped as Ticagrelor is a better antiplatelet agent when given in combination with low dose aspirin. Also, aspirin dose was reduced to enhance the efficacy of Ticagrelor and provide better secondary prevention for vascular diseases.

scholarly journals Acute myocardial infarction in young adults: features of pathogenesis, disease course and justification of strategy for prevention of complications

2019 ◽  
Vol 26 (4) ◽  
pp. 32-43
Author(s):  
O. M. Parkhomenko ◽  
Ya. M. Lutay ◽  
O. I. Irkin ◽  
D. O. Bilyi ◽  
A. O. Stepura ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Adults ◽  
Young Patients ◽  
Coronary Vessels ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Premature Coronary Artery Disease ◽  
Ventricular Ejection Fraction ◽  
Arrhythmogenic Substrate

We retrospectively and prospectively studied 835 patients with acute myocardial infarction (AMI) under the age of 45 and older. Depending on age, patients were divided into two groups: < 45 years and ≥ 45 years. In 189 patients under 45 years of age, the main risk factors leading to the development of ST-elevation myocardial infarction were male sex (OR 6.58; 95 % CI (2.64–16.41), smoking (OR 2.02; 95 % CI (1.44–2.82) and family history of premature coronary artery disease (OR 1.75; 95 % CI (1.21–2.54). According to coronary angiography, AMI patients under 45 years of age in most cases showed no hemodynamically significant coronary vessels damage and had a different course of AMI caused by other reasons – aneurysms of the coronary arteries, muscle bridges, coronary spasm, spontaneous dissections. It was found that 10 % of young patients who did not have obstructive lesions of coronary vessels, according to magnetic resonance imaging (MRI) had focal myocarditis. However, it is noted that in patients under 45 years of age, the presence of familial hypercholesterolemia (FH) may affect the development of AMI. Thus, according to the DLCNS criteria, FH was more frequently reported in young patients than in patients older than 45 years (7.34 % vs 1.32 % (p<0.05)). Hospital course of AMI in young adults was more favorable, with fewer complications. Data from studies of flow-dependent vasodilation have shown that young patients have worse endothelial function on the 1st day of AMI (p=0.043), but better recovery of it in the dynamics of observation. However, in young patients, early (day 7, p=0.029) and late (day 90, p=0.041) left ventricular dilatation was more commonly reported compared with older patients. According to the MRI data on day 1 and in the dynamics (90 days), it was found that, despite the higher prevalence of AMI, young patients have better recovery of contractile myocardial function. The arrhythmogenic substrate (according to late ventricular potential) for life-threatening arrhythmias was more commonly recorded in the older age group at the beginning of the development of AMI, but it was detected with the same frequency in both groups during prolonged observation (6–12 months). Despite better survival and fewer complications during long-term follow-up (4.9 years on average), the greatest impact on the development of the combined endpoint (cardiovascular death / recurrent myocardial infarction / stroke) and death from any cause was made by the patients’ age up to 35 years (best prognosis), concomitant hypertension (worsens prognosis) and low left ventricular ejection fraction (increases complications). The study indicates the possibility of implementing a secondary prevention system in AMI patients of young age through careful (active) observation and control of adherence to treatment and the adequacy of its implementation.

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