scholarly journals Development of Plasma Vitellogenin Assay for Estrogenic Effects of Endocrine-Disrupting Chemicals Using Ovariectomized Goldfish (Carassius auratus)

2004 ◽  
Vol 50 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Hiroshi Ishibashi ◽  
Makito Kobayashi ◽  
Yuki Tomiyasu ◽  
Maki Miyahara ◽  
Katsuyasu Tachibana ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Endocrine Disrupting Chemicals ◽  
Goldfish Carassius Auratus ◽  
Estrogenic Effects ◽  
Endocrine Disrupting

scholarly journals In Vivo Testing System for Determining the Estrogenic Activity of Endocrine-Disrupting Chemicals(EDCs) in Goldfish (Carassius auratus).

2001 ◽  
Vol 47 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Hiroshi Ishibashi ◽  
Katsuyasu Tachibana ◽  
Mutsuyosi Tsuchimoto ◽  
Kiyoshi Soyano ◽  
Yasuhiro Ishibashi ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Testing System ◽  
Goldfish Carassius Auratus ◽  
Endocrine Disrupting ◽  
In Vivo Testing

scholarly journals The distributions, removals and estrogenic effects of selected endocrine disrupting chemicals in two drinking water factories in China

2012 ◽  
Vol 11 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Hong-Chang Zhang ◽  
Ting Xu ◽  
Xia-lin Hu ◽  
Wei-hai Pang ◽  
Da-Qiang Yin
Keyword(s):  
Drinking Water ◽  
Treatment Process ◽  
Limit Of Detection ◽  
Solid Phase ◽  
Endocrine Disrupting Chemicals ◽  
Estrogen Receptor Α ◽  
Raw Water ◽  
Water Treatment Process ◽  
Estrogenic Effects ◽  
Endocrine Disrupting

The distributions and effects of 31 selected endocrine disrupting chemicals (EDCs) in two drinking water factories were analyzed in this study. The distributions of EDCs were analyzed by solid phase extraction (SPE) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS). The concentrations of these EDCs were from lower than the LOD (limit of detection) to 23.13 ng L − 1 in the samples; most of them were lower than 1 ng L − 1. The highest concentration (23.13 ± 1.45 ng L − 1) was detected in the raw water. Twenty-six chemicals were found in the raw water and only five in the finished water of drinking water factory A, while 25 chemicals were detected in the raw water and two in the finished water of drinking water factory B. The results indicate that most of the EDCs can be removed by the water treatment process. In the advanced treatment process, the ozonation processes have the highest removal efficiency. Separate analyses in May and September show similar results. Apart from the chemical analysis, yeast strain transformed when the estrogen receptor α (ERα) gene was employed to test the estrogenic effects of the water samples. Due to the low concentrations of these EDCs, no significant estrogenic effects were found from the samples.

Environmental estrogenic effects and gonadal development in wild goldfish (Carassius auratus)

2008 ◽  
Vol 150 (1-4) ◽  
pp. 397-404 ◽  
Author(s):  
Chun-Ri Li ◽  
Sang-Hoon Lee ◽  
So-Sun Kim ◽  
Andre Kim ◽  
Keun Woo Lee ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Gonadal Development ◽  
Goldfish Carassius Auratus ◽  
Estrogenic Effects

Estrogenic effects of monocrotophos standard on male goldfish, Carassius auratus: induction of vitellogenin synthesis and alteration of testicular ultrastructure and function

2014 ◽  
Vol 64 (4) ◽  
pp. 311-331
Author(s):  
Zhenyu Wang ◽  
Meng Sun ◽  
Hua Tian ◽  
Su Gao ◽  
Wei Wang ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Quantitative Methods ◽  
Gonadosomatic Index ◽  
Qualitative And Quantitative Methods ◽  
Goldfish Carassius Auratus ◽  
Estrogenic Effects ◽  
Endogenous Estrogen ◽  
Vitellogenin Synthesis ◽  
Ultrastructure And Function ◽  
And Function

Monocrotophos has been shown to exert estrogenic effects on teleosts. However, it has not been determined whether monocrotophos itself is the component that is responsible for exerting these estrogenic activities. Therefore, this study was carried out to investigate the estrogenic effects of monocrotophos standard in male goldfish (Carassius auratus), after a 21-day semi-static toxicity test. The induction of vitellogenin synthesis in males exposed to monocrotophos was confirmed with qualitative and quantitative methods. The observed increase in endogenous estrogen levels in males exposed to monocrotophos might explain the induction of vitellogenin. Moreover, we observed a decreased gonadosomatic index, ultrastructure damage of sperm and Sertoli cells, and several alterative testicular enzyme activities in males exposed to monocrotophos, which possibly affect spermatogenesis and male fertility. Our study showed the potential estrogenic effects of monocrotophos standard may act via the induction of vitellogenin synthesis and alteration of testicular ultrastructure and function in male goldfish.

A high throughput screening method for endocrine disrupting chemicals in tap water and milk samples based on estrogen receptor α and gold nanoparticles

2020 ◽  
Vol 12 (2) ◽  
pp. 200-204 ◽  
Author(s):  
Mengyue Liu ◽  
Shengqiang Zhang ◽  
Shuyuan Du ◽  
Shuxue Pang ◽  
Xiaoyu Liu ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Tap Water ◽  
Endocrine Disrupting Chemicals ◽  
Screening Method ◽  
Estrogen Receptor Α ◽  
Food Samples ◽  
Screening Methods ◽  
Estrogenic Effects ◽  
Endocrine Disrupting

Increasing concern over endocrine disrupting chemicals (EDCs) in environmental and food samples has created the demand for rapid and high throughput screening methods to evaluate their estrogenic effects.

Known and emerging factors modulating estrogenic effects of endocrine-disrupting chemicals

2014 ◽  
Vol 22 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Wanglong Zhang ◽  
Yu Luo ◽  
Li Zhang ◽  
Qian Cai ◽  
Xuejun Pan
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Posttranslational Modification ◽  
Splice Variants ◽  
Physiological Responses ◽  
Endocrine Disrupting Chemicals ◽  
Estrogenic Effects ◽  
Endocrine Disrupting ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

A variety of endocrine-disrupting chemicals (EDCs) have estrogenic effects and are termed xenoestrogens (XEs). The genomic pathway mediated by estrogen receptors (ERs) has been considered the major explanation for the estrogenic effects elicited by XEs. Presently, nongenomic pathways have achieved considerably more attention because the genomic pathways cannot fully elucidate many biological and physiological responses. Genomic and nongenomic pathways act either separately or cooperatively. XEs activate a variety of signaling pathways and downstream kinases, which in turn alter the posttranslational modification and activation of ERs. Classical ERs and their splice variants reside at the membrane and mediate rapid effects cooperatively with G protein-coupled estrogen receptor 1 (GPER), G protein, and many other signaling molecules. GPER seems more effective in mediating the synthetic chemical-induced effects. There are also feedback and feedforward mechanisms between both pathways. Numerous factors may affect both pathways. Recently, some new layers of regulation on the estrogenic effects were identified. In this review, we summarize these multiple regulation layers and discuss the newly identified factors.

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