scholarly journals Osmolyte Changes the Binding Affinity and Mode of Interaction of Minor Groove Binder Hoechst 33258 with Calf Thymus DNA

2010 ◽  
Vol 58 (11) ◽  
pp. 1447-1454 ◽  
Author(s):  
Anuradha ◽  
Mohammad Sarwar Alam ◽  
Nabo Kumar Chaudhury
Keyword(s):  
Binding Affinity ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Minor Groove Binder ◽  
Hoechst 33258 ◽  
Calf Thymus

scholarly journals Comparative Analysis of [Au(en)2]3+ and [Pt(en)2]2+ non Covalent Binding to Calf Thymus DNA

2000 ◽  
Vol 7 (5) ◽  
pp. 253-256 ◽  
Author(s):  
Giordana Marcon ◽  
Tim O'Connell ◽  
Pierluigi Orioli ◽  
Luigi Messori
Keyword(s):  
Comparative Analysis ◽  
Electrostatic Interactions ◽  
Covalent Binding ◽  
Minor Groove ◽  
Sodium Cyanide ◽  
Calf Thymus Dna ◽  
Minor Groove Binder ◽  
Calf Thymus ◽  
Dna Conformations ◽  
A Minor

Reactions of the complexes bisethylendiammine gold(III) and bisethylendiammine platinum(II) with calfthymus DNA were comparatively analysed. Both complexes bind DNA non-covalently most probably on the basis of electrostatic interactions. Binding of either complex at low ratios results into modest modifications of B-type DNA conformations, as detected by CD. Far larger CD alterations are observed at high ratios. The gold(III) chromophore is scarcely perturbed by DNA addition Binding of [Au(en)2]Cl3 to calf thymus DNA is reversed by sodium cyanide. By analogy with the case of [Pt(en)2]Cl2 it is suggested that Auen acts as a minor groove binder.

Caffeic acid binds to the minor groove of calf thymus DNA: A multi-spectroscopic, thermodynamics and molecular modelling study

2017 ◽  
Vol 98 ◽  
pp. 319-328 ◽  
Author(s):  
Tarique Sarwar ◽  
Hassan Mubarak Ishqi ◽  
Sayeed Ur Rehman ◽  
Mohammed Amir Husain ◽  
Yusra Rahman ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Molecular Modelling ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Study

Changes in binding affinity between ofloxacin and calf thymus DNA in the presence of histone H1: Spectroscopic and molecular modeling investigations

2018 ◽  
Vol 203 ◽  
pp. 599-608 ◽  
Author(s):  
Farzad Dehghani Sani ◽  
Niloufar Shakibapour ◽  
Sima Beigoli ◽  
Hamid Sadeghian ◽  
Maral Hosainzadeh ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Binding Affinity ◽  
Histone H1 ◽  
Calf Thymus Dna ◽  
Calf Thymus

DUPLEX–TRIPLEX TRANSITION IN COMPLEXES OF NUCLEIC ACIDS WITH HOECHST 33258

2021 ◽  
Vol 55 (1 (254)) ◽  
pp. 39-45
Author(s):  
Marine A. Parsadanyan
Keyword(s):  
Ionic Strength ◽  
Nucleic Acids ◽  
Calf Thymus Dna ◽  
Hoechst 33258 ◽  
Groove Binding ◽  
Melting Curves ◽  
Calf Thymus ◽  
High Concentrations

The study of complexes of groove binding ligand Hoechst 33258 (H33258) with Calf Thymus DNA has been carried out. The data obtained revealed that the melting curves of the complexes of H33258 with DNA are monophasic at low ligand concentrations (0 < r ≤ 0.2) and become biphasic at relatively high concentrations (0.2 < r ≤ 0.33). This effect was revealed to depend on the ionic strength of the solution, and can also occur at high concentrations of the ligand. Comparison of the obtained data with the results for poly(rA)-poly(rU) and poly(dA)-poly(dT) shows a coincidence in the case of DNA and poly(rA)-poly(rU), while in the case of poly(dA)-poly(dT) the melting curves become biphasic at low ligand concentrations and actually do not depend on the ionic strength of the solution.

Cholinergic drugs bind at minor groove and reverse induced oxidative stress of calf thymus DNA: A new perspective towards an unexplored therapeutic efficacy

2021 ◽  
Author(s):  
Prayasee Baruah ◽  
Pynskhemborlang Tep Phanrang ◽  
Ibemhanbi Konthoujam ◽  
Kripamoy Aguan ◽  
Sivaprasad Mitra
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Efficacy ◽  
Deoxyribonucleic Acid ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Cholinergic Drugs ◽  
Calf Thymus ◽  
Life Threatening ◽  
Dna Backbone ◽  
New Perspective

Conformational alterations in the structure of deoxyribonucleic acid (DNA) due to oxidative stress in the DNA backbone are known to be at the root of many life-threatening diseases. Clear comprehension...

scholarly journals Interaction of DNA Minor Groove Binder Hoechst 33258 with Bovine Serum Albumin

2009 ◽  
Vol 57 (5) ◽  
pp. 481-486 ◽  
Author(s):  
Himanshu Ojha ◽  
Bhaskar Mohan Murari ◽  
Sneh Anand ◽  
Mohd Imtaiyaz Hassan ◽  
Faizan Ahmad ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Hoechst 33258 ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder
Sign in / Sign up

Export Citation Format

Share Document