scholarly journals Comparative Analysis of [Au(en)2]3+ and [Pt(en)2]2+ non Covalent Binding to Calf Thymus DNA

2000 ◽  
Vol 7 (5) ◽  
pp. 253-256 ◽  
Author(s):  
Giordana Marcon ◽  
Tim O'Connell ◽  
Pierluigi Orioli ◽  
Luigi Messori
Keyword(s):  
Comparative Analysis ◽  
Electrostatic Interactions ◽  
Covalent Binding ◽  
Minor Groove ◽  
Sodium Cyanide ◽  
Calf Thymus Dna ◽  
Minor Groove Binder ◽  
Calf Thymus ◽  
Dna Conformations ◽  
A Minor

Reactions of the complexes bisethylendiammine gold(III) and bisethylendiammine platinum(II) with calfthymus DNA were comparatively analysed. Both complexes bind DNA non-covalently most probably on the basis of electrostatic interactions. Binding of either complex at low ratios results into modest modifications of B-type DNA conformations, as detected by CD. Far larger CD alterations are observed at high ratios. The gold(III) chromophore is scarcely perturbed by DNA addition Binding of [Au(en)2]Cl3 to calf thymus DNA is reversed by sodium cyanide. By analogy with the case of [Pt(en)2]Cl2 it is suggested that Auen acts as a minor groove binder.

Ce(IV)-mediated formation of benzenediazonium ion from a non-aminoazo dye, 1-phenylazo-2-hydroxy-naphthalene (Sudan I) and its binding to DNA

1989 ◽  
Vol 54 (7) ◽  
pp. 2021-2026
Author(s):  
Marie Stiborová ◽  
Befekadu Asfaw ◽  
Pavel Anzenbacher
Keyword(s):  
Azo Dyes ◽  
Acidic Medium ◽  
Model System ◽  
Calf Thymus Dna ◽  
Suitable Model ◽  
Principal Product ◽  
Calf Thymus ◽  
Sudan I ◽  
A Minor

Ce(IV) ions in acidic medium convert a carcinogenic non-aminoazo dye, 1-phenylazo-2-hydroxy-naphthalene (Sudan I) into an ultimate carcinogen, which binds to calf thymus DNA. The principal product of Sudan I oxidation by the Ce(IV) system is the benzenediazonium ion. A minor product is the dihydroxyderivative of Sudan I, 1-(4-hydroxyphenylazo)-2,6-dihydroxynaphthalene. Other minor coloured products (yellow and brown) were not identified. The principal product (the benzenediazonium ion) is responsible for the carcinogenicity of Sudan I, as it covalently binds to DNA. Ce(IV) ions in acidic medium represent a suitable model system, which imitates the activation route of carcinogenic azo dyes.

Specific DNA Recognition by a Synthetic, Monomeric Cys2His2 Zinc-Finger Peptide Conjugated to a Minor-Groove Binder

2007 ◽  
Vol 119 (36) ◽  
pp. 7010-7014 ◽  
Author(s):  
Olalla Vázquez ◽  
M. Eugenio Vázquez ◽  
Juan B. Blanco ◽  
Luis Castedo ◽  
José L. Mascareñas
Keyword(s):  
Zinc Finger ◽  
Dna Recognition ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
A Minor ◽  
Zinc Finger Peptide

scholarly journals Fluorescence and Molecular Simulation Studies on the Interaction between Imidazolium-Based Ionic Liquids and Calf Thymus DNA

Processes ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 13
Author(s):  
Khairulazhar Jumbri ◽  
Mohd Azlan Kassim ◽  
Normawati M. Yunus ◽  
Mohd Basyaruddin Abdul Rahman ◽  
Haslina Ahmad ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Double Helix ◽  
Structural Features ◽  
Docking Studies ◽  
Calf Thymus Dna ◽  
Valuable Insight ◽  
Screening Model ◽  
Calf Thymus ◽  
A Minor ◽  
Insight Into

This work presents a molecular level investigation on the nature and mode of binding between imidazolium-based ionic liquids (ILs) ([Cnbim]Br where n = 2, 4, 6) with calf thymus DNA. This investigation offers valuable insight into the mechanisms of interactions that can affect the structural features of DNA and possibly cause the alteration or inhibition of DNA function. To expedite analysis, the study resorted to using molecular docking and COnductor like Screening MOdel for Real Solvents (COSMO-RS) in conjunction with fluorescence spectroscopic data for confirmation and validation of computational results. Both the fluorescence and docking studies consistently revealed a weak interaction between the two molecules, which corresponded to the binding energy of a stable docking conformation in the range of −5.19 to −7.75 kcal mol−1. As predicted, the rod-like structure of imidazolium-based ILs prefers to bind to the double-helix DNA through a minor groove. Interestingly, the occurrence of T-shape π-π stacking was observed between the amine group in adenine that faces the aromatic ring of imidazole. In addition, data of COSMO-RS for the interaction of individual nucleic acid bases to imidazolium-based ILs affirmed that ILs showed a propensity to bind to different bases, the highest being guanine followed by cytosine, thymine, uracil, and adenine.

scholarly journals Detection of the Bacillus anthracis gyrA Gene by Using a Minor Groove Binder Probe

2004 ◽  
Vol 42 (1) ◽  
pp. 179-185 ◽  
Author(s):  
W. Hurtle ◽  
E. Bode ◽  
D. A. Kulesh ◽  
R. S. Kaplan ◽  
J. Garrison ◽  
...  
Keyword(s):  
Bacillus Anthracis ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Gyra Gene ◽  
Minor Groove Binder Probe ◽  
A Minor

scholarly journals Sensitive Assay for Quantification of Hepatitis B Virus Mutants by Use of a Minor Groove Binder Probe and Peptide Nucleic Acids

2010 ◽  
Vol 48 (12) ◽  
pp. 4487-4494 ◽  
Author(s):  
Shuhei Hige ◽  
Yoichi Yamamoto ◽  
Shigeru Yoshida ◽  
Tomoe Kobayashi ◽  
Hiromasa Horimoto ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Minor Groove ◽  
Sensitive Assay ◽  
Minor Groove Binder ◽  
B Virus ◽  
Minor Groove Binder Probe ◽  
A Minor

Caffeic acid binds to the minor groove of calf thymus DNA: A multi-spectroscopic, thermodynamics and molecular modelling study

2017 ◽  
Vol 98 ◽  
pp. 319-328 ◽  
Author(s):  
Tarique Sarwar ◽  
Hassan Mubarak Ishqi ◽  
Sayeed Ur Rehman ◽  
Mohammed Amir Husain ◽  
Yusra Rahman ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Molecular Modelling ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Study
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