scholarly journals Solid-Phase Tandem Radical Addition-Cyclization Reaction: Triethylborane-Induced Reaction of Oxime Ethers Anchored to Polymer Support

2004 ◽  
Vol 52 (7) ◽  
pp. 842-847 ◽  
Author(s):  
Hideto Miyabe ◽  
Hirotaka Tanaka ◽  
Takeaki Naito
Keyword(s):  
Solid Phase ◽  
Radical Addition ◽  
Cyclization Reaction ◽  
Polymer Support ◽  
Induced Reaction

scholarly journals Diastereoselective Solid-Phase Radical Addition to Oxime Ether Anchored to Polymer Support

2003 ◽  
Vol 51 (5) ◽  
pp. 540-544 ◽  
Author(s):  
Hideto Miyabe ◽  
Chihiro Konishi ◽  
Takeaki Naito
Keyword(s):  
Solid Phase ◽  
Radical Addition ◽  
Polymer Support ◽  
Oxime Ether

Stereocontrol in Solid-Phase Radical Reactions:  Radical Addition to Oxime Ether Anchored to Polymer Support

2000 ◽  
Vol 2 (10) ◽  
pp. 1443-1445 ◽  
Author(s):  
Hideto Miyabe ◽  
Chihiro Konishi ◽  
Takeaki Naito
Keyword(s):  
Solid Phase ◽  
Radical Addition ◽  
Radical Reactions ◽  
Polymer Support ◽  
Oxime Ether

scholarly journals An Improved Procedure for the Preparation of Thrombin Low Molecular Weight Substrates - Peptide p-Nitroanilides

2018 ◽  
Vol 1 (4) ◽  
pp. e00057 ◽  
Author(s):  
A.A Chistov ◽  
A.V. Talanova ◽  
M.V. Melnikova ◽  
S.S. Kuznetsova ◽  
E.F. Kolesanova
Keyword(s):  
Molecular Weight ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Potassium Sulfate ◽  
Polymer Support ◽  
Low Molecular Weight ◽  
Chromogenic Substrate ◽  
Peptide Substrates ◽  
Terminal Amino ◽  
Hydrolysis Of

Low molecular weight chromogenic thrombin peptide substrates, p-nitroanilides of short peptides protected at their N-terminal amino group, were prepared by solid-phase peptide synthesis on polystyrene-divinylbenzene polymer with trityl groups with preliminary attached p-phenylene diamine moiety. After the cleavage from the resin peptide p-aminoanilides were mildly oxidized to p-nitroanilides with the mixture of potassium sulfate and persulfate. Adsorption onto polymer support Bio-Beads SM-2 with further elution by acetonitrile allowed easy separating peptide p-nitroanilides from the oxidizer and obtaining the thrombin chromogenic substrate preparations with the target substance contents of not less than 95% and yields of 30-40%. Thrombin effectively catalyzed hydrolysis of the prepared substrates with KM and Vmax values of 29-134 mM and 0.03-1/16 mM/s, respectively.

Solid-Phase Free Radical Addition of Thiols to Allyl Ethers

Synlett ◽  
2001 ◽  
Vol 2001 (03) ◽  
pp. 0439-0441 ◽  
Author(s):  
Robert Plourde ◽  
Leland L. Johnson ◽  
Rachel K. Longo
Keyword(s):  
Free Radical ◽  
Solid Phase ◽  
Radical Addition ◽  
Allyl Ethers ◽  
Free Radical Addition

Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: synthesis of 6-alkylated phenanthridines

2020 ◽  
Vol 18 (18) ◽  
pp. 3487-3491 ◽  
Author(s):  
Pedro López-Mendoza ◽  
Luis D. Miranda
Keyword(s):  
Radical Addition ◽  
Cyclization Reaction ◽  
Modular Approach ◽  
Reaction Sequence

A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.

Solid-phase intermolecular radical reactions 1. Sulfonyl radical addition to isolated alkenes and alkynes

1999 ◽  
Vol 40 (40) ◽  
pp. 7285-7288 ◽  
Author(s):  
Stephen Caddick ◽  
Daniel Hamza ◽  
Sjoerd N Wadman
Keyword(s):  
Solid Phase ◽  
Radical Addition ◽  
Radical Reactions

Free radical addition of haloalkanes to polymer bound olefins and its application to the solid-phase synthesis of pyrethroids

2002 ◽  
Vol 43 (43) ◽  
pp. 7817-7819 ◽  
Author(s):  
H.M.S Kumar ◽  
P.Pawan Chakravarthy ◽  
M Shesha Rao ◽  
P.Sunder Ram Reddy ◽  
J.S Yadav
Keyword(s):  
Free Radical ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Radical Addition ◽  
Phase Synthesis ◽  
Free Radical Addition

Solid-phase synthesis of α-amino acids by radical addition to adehydroalanine derivative

1999 ◽  
Vol 40 (24) ◽  
pp. 4535-4538 ◽  
Author(s):  
Anne-Marie Yim ◽  
Yves Vidal ◽  
Philippe Viallefont ◽  
Jean Martinez
Keyword(s):  
Amino Acids ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Radical Addition ◽  
Phase Synthesis
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