scholarly journals Diastereoselective Solid-Phase Radical Addition to Oxime Ether Anchored to Polymer Support

2003 ◽  
Vol 51 (5) ◽  
pp. 540-544 ◽  
Author(s):  
Hideto Miyabe ◽  
Chihiro Konishi ◽  
Takeaki Naito
Keyword(s):  
Solid Phase ◽  
Radical Addition ◽  
Polymer Support ◽  
Oxime Ether

Stereocontrol in Solid-Phase Radical Reactions:  Radical Addition to Oxime Ether Anchored to Polymer Support

2000 ◽  
Vol 2 (10) ◽  
pp. 1443-1445 ◽  
Author(s):  
Hideto Miyabe ◽  
Chihiro Konishi ◽  
Takeaki Naito
Keyword(s):  
Solid Phase ◽  
Radical Addition ◽  
Radical Reactions ◽  
Polymer Support ◽  
Oxime Ether

Tandem Radical-Addition—Aldol-Type Reaction of an α,β-Unsaturated Oxime Ether.

ChemInform ◽  
2006 ◽  
Vol 37 (5) ◽  
Author(s):  
Masafumi Ueda ◽  
Hideto Miyabe ◽  
Hisako Sugino ◽  
Okiko Miyata ◽  
Takeaki Naito
Keyword(s):  
Radical Addition ◽  
Oxime Ether ◽  
Type Reaction

scholarly journals An Improved Procedure for the Preparation of Thrombin Low Molecular Weight Substrates - Peptide p-Nitroanilides

2018 ◽  
Vol 1 (4) ◽  
pp. e00057 ◽  
Author(s):  
A.A Chistov ◽  
A.V. Talanova ◽  
M.V. Melnikova ◽  
S.S. Kuznetsova ◽  
E.F. Kolesanova
Keyword(s):  
Molecular Weight ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Potassium Sulfate ◽  
Polymer Support ◽  
Low Molecular Weight ◽  
Chromogenic Substrate ◽  
Peptide Substrates ◽  
Terminal Amino ◽  
Hydrolysis Of

Low molecular weight chromogenic thrombin peptide substrates, p-nitroanilides of short peptides protected at their N-terminal amino group, were prepared by solid-phase peptide synthesis on polystyrene-divinylbenzene polymer with trityl groups with preliminary attached p-phenylene diamine moiety. After the cleavage from the resin peptide p-aminoanilides were mildly oxidized to p-nitroanilides with the mixture of potassium sulfate and persulfate. Adsorption onto polymer support Bio-Beads SM-2 with further elution by acetonitrile allowed easy separating peptide p-nitroanilides from the oxidizer and obtaining the thrombin chromogenic substrate preparations with the target substance contents of not less than 95% and yields of 30-40%. Thrombin effectively catalyzed hydrolysis of the prepared substrates with KM and Vmax values of 29-134 mM and 0.03-1/16 mM/s, respectively.

Solid-Phase Free Radical Addition of Thiols to Allyl Ethers

Synlett ◽  
2001 ◽  
Vol 2001 (03) ◽  
pp. 0439-0441 ◽  
Author(s):  
Robert Plourde ◽  
Leland L. Johnson ◽  
Rachel K. Longo
Keyword(s):  
Free Radical ◽  
Solid Phase ◽  
Radical Addition ◽  
Allyl Ethers ◽  
Free Radical Addition

Development of radical addition–cyclization–elimination reaction of oxime ether and its application to formal synthesis of (±)-martinelline

Tetrahedron ◽  
2007 ◽  
Vol 63 (40) ◽  
pp. 10092-10117 ◽  
Author(s):  
Okiko Miyata ◽  
Atsushi Shirai ◽  
Shintaro Yoshino ◽  
Toshiki Nakabayashi ◽  
Yoshifumi Takeda ◽  
...  
Keyword(s):  
Radical Addition ◽  
Elimination Reaction ◽  
Oxime Ether ◽  
Formal Synthesis

ChemInform Abstract: Carbon Radical Addition to Glyoxylic Oxime Ether via Iodine Atom-Transfer Process.

ChemInform ◽  
2010 ◽  
Vol 30 (30) ◽  
pp. no-no
Author(s):  
Hideto Miyabe ◽  
Masafumi Ueda ◽  
Naoko Yoshioka ◽  
Takeaki Naito
Keyword(s):  
Transfer Process ◽  
Iodine Atom ◽  
Radical Addition ◽  
Atom Transfer ◽  
Oxime Ether

Carbon Radical Addition to Glyoxylic Oxime Ether via Iodine Atom-Transfer Process

Synlett ◽  
1999 ◽  
Vol 1999 (4) ◽  
pp. 465-467 ◽  
Author(s):  
Hideto Miyabe ◽  
Masafumi Ueda ◽  
Naoko Yoshioka ◽  
Takeaki Naito
Keyword(s):  
Transfer Process ◽  
Iodine Atom ◽  
Radical Addition ◽  
Atom Transfer ◽  
Oxime Ether

Tandem Radical-Addition-Aldol-Type Reaction of an α,β-Unsaturated Oxime Ether

2005 ◽  
Vol 117 (38) ◽  
pp. 6346-6349 ◽  
Author(s):  
Masafumi Ueda ◽  
Hideto Miyabe ◽  
Hisako Sugino ◽  
Okiko Miyata ◽  
Takeaki Naito
Keyword(s):  
Radical Addition ◽  
Oxime Ether ◽  
Type Reaction

Asymmetric Synthesis of α-Amino Acids Based on Carbon Radical Addition to Glyoxylic Oxime Ether

2000 ◽  
Vol 65 (1) ◽  
pp. 176-185 ◽  
Author(s):  
Hideto Miyabe ◽  
Chikage Ushiro ◽  
Masafumi Ueda ◽  
Kumiko Yamakawa ◽  
Takeaki Naito
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Radical Addition ◽  
Oxime Ether
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