scholarly journals Synthetic approaches to fumitremorgins. III. Synthesis of optically active pentacyclic ring systems, and their oxidation at ring C.

1989 ◽  
Vol 37 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Masako NAKAGAWA ◽  
Hiroshi FUKUSHIMA ◽  
Tomohiko KAWATE ◽  
Mitsuya HONGU ◽  
Teruaki UNE ◽  
...  
Keyword(s):  
Optically Active ◽  
Ring Systems ◽  
Synthetic Approaches

scholarly journals Metal Complexes of Oxadiazole Ligands: An Overview

2019 ◽  
Vol 20 (14) ◽  
pp. 3483 ◽  
Author(s):  
Giovanni Salassa ◽  
Alessio Terenzi
Keyword(s):  
Metal Complexes ◽  
Medicinal Chemistry ◽  
Heterocyclic Ring ◽  
Organic Ligands ◽  
Ring Systems ◽  
General Overview ◽  
Research Fields ◽  
Scientific Disciplines ◽  
Synthetic Approaches

Oxadizoles are heterocyclic ring systems that find application in different scientific disciplines, from medicinal chemistry to optoelectronics. Coordination with metals (especially the transition ones) proved to enhance the intrinsic characteristics of these organic ligands and many metal complexes of oxadiazoles showed attractive characteristics for different research fields. In this review, we provide a general overview on different metal complexes and polymers containing oxadiazole moieties, reporting the principal synthetic approaches adopted for their preparation and showing the variety of applications they found in the last 40 years.

scholarly journals Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Joseph C. Sloop
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Synthetic Methods ◽  
Ring Systems ◽  
Heterocyclic Molecules ◽  
The Past ◽  
Ring Assembly ◽  
Metal Catalyzed ◽  
Synthetic Approaches ◽  
Isoquinoline Derivatives

Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the incorporation of fluorine-containing functional groups. Specifically, efficient synthetic methods and regioselectivity in the incorporation of functional groups into isoquinoline ring systems are examined.

scholarly journals Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Takuya Imaoka ◽  
Makoto Iwata ◽  
Takafumi Akimoto ◽  
Kazuo Nagasawa
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Activity ◽  
Biological Activities ◽  
Structural Complexity ◽  
Marine Alkaloids ◽  
Ring Systems ◽  
Agonistic Activity ◽  
Synthetic Approaches

Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been carried out to develop strategies for the synthesis of these natural products. Members of PIAs ( eg., 2-7) which contain tetracyclic ring systems possessing characteristic cyclic guanidine or urea moieties show significant biological activities including anticancer activity and agonistic activity against the adrenoceptor. In this review investigations of the total synthesis of the representative tetracyclic PIAs dibromophakellin (2) and dibromophakellstatin (3) are described.

Synthetic Approaches to Optically Active Macrolides Containing Hydrazide Fragments of L-(+)-Tartaric Acid from (+)-3-Carene, (+)-α-Pinene, and S-(–)-Limonene

2014 ◽  
Vol 50 (4) ◽  
pp. 658-660 ◽  
Author(s):  
G. Yu. Ishmuratov ◽  
M. P. Yakovleva ◽  
M. A. Shutova ◽  
R. R. Muslukhov ◽  
N. M. Ishmuratova ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Optically Active ◽  
Synthetic Approaches

scholarly journals General Synthesis of Cyclopropanols via Organometallic Addition to 1-Sulfonylcyclopropanols as Cyclopropanone Precursors

2020 ◽  
Author(s):  
Roger Machín Rivera ◽  
Yujin Jang ◽  
Christopher M. Poteat ◽  
Vincent Lindsay
Keyword(s):  
Optically Active ◽  
Organometallic Reagents ◽  
Tertiary Alcohols ◽  
Mild Conditions ◽  
Synthetic Approaches ◽  
General Synthesis

The addition of organometallic reagents to ketones constitutes one of the most straightforward synthetic approaches to tertiary alcohols. However, due to the absence of a well-behaved class of cyclopropanone surrogates accessible in enantioenriched form, such a trivial synthetic disconnection has only received very little attention in the literature for the formation of tertiary cyclopropanols. In this work, we report a simple and high-yielding synthesis 1-substituted cyclopropanols via the addition of diverse organometallic reagents to 1- phenylsulfonylcyclopropanols, acting here as in situ precursors of the corresponding cyclopropanones.The transformation is shown to be amenable to sp, sp2 or sp3 -hybridized organometallic C-nucleophiles under mild conditions, and the use of enantioenriched substrates led to highly diastereoselective additions and the formation of optically active cyclopropanols.

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