scholarly journals Metal Complexes of Oxadiazole Ligands: An Overview

2019 ◽  
Vol 20 (14) ◽  
pp. 3483 ◽  
Author(s):  
Giovanni Salassa ◽  
Alessio Terenzi
Keyword(s):  
Metal Complexes ◽  
Medicinal Chemistry ◽  
Heterocyclic Ring ◽  
Organic Ligands ◽  
Ring Systems ◽  
General Overview ◽  
Research Fields ◽  
Scientific Disciplines ◽  
Synthetic Approaches

Oxadizoles are heterocyclic ring systems that find application in different scientific disciplines, from medicinal chemistry to optoelectronics. Coordination with metals (especially the transition ones) proved to enhance the intrinsic characteristics of these organic ligands and many metal complexes of oxadiazoles showed attractive characteristics for different research fields. In this review, we provide a general overview on different metal complexes and polymers containing oxadiazole moieties, reporting the principal synthetic approaches adopted for their preparation and showing the variety of applications they found in the last 40 years.

One-pot synthesis of 3,5-diaryl substituted-1,2,4-oxadiazoles using gem-dibromomethylarenes

2019 ◽  
Vol 97 (9) ◽  
pp. 690-696 ◽  
Author(s):  
Kambappa Vinaya ◽  
Ganganahalli K. Chandrashekara ◽  
Prasanna D. Shivaramu
Keyword(s):  
Benzoic Acid ◽  
Medicinal Chemistry ◽  
Heterocyclic Ring ◽  
Efficient Synthesis ◽  
One Pot ◽  
Ring Systems ◽  
One Pot Synthesis ◽  
Material Chemistry ◽  
Two Component

1,2,4-Oxadiazole is one of the most promising heterocyclic ring systems in medicinal chemistry. In the present paper, we report the method for an efficient one-pot synthesis of 3,5-diaryl substituted 1,2,4-oxadiazoles using a two-component reaction of gem-dibromomethylarenes with amidoximes in good yields. In this method, gem-dibromomethylarenes are used as benzoic acid equivalents for the efficient synthesis of aryl-substituted 1,2,4-oxadiazoles. It is anticipated that this methodology will have versatile applications in the practical syntheses of various molecules of both medicinal and material chemistry importance.

THE ISSUE OF CONTEXT AND SOCIOLOGICAL POETICS OF THE "BAKHTIN'S CIRCLE"

2020 ◽  
pp. 10-18
Author(s):  
Grigorii I. Nesmeyanov ◽  
Keyword(s):  
Discourse Analysis ◽  
Intellectual History ◽  
Literary Theory ◽  
Philosophical Hermeneutics ◽  
Research Fields ◽  
Interdisciplinary Field ◽  
Scientific Disciplines ◽  
Methodological Approaches ◽  
A Current

The article formulates main questions related to the concept of context. The issue of context is considered as a current-day interdisciplinary field of research. There are many definitions of context in dictionaries and in various humanities (including scientific disciplines). In connection with that issue various methodological approaches arise in the humanities, which can be designated by the umbrella term “contextual”. By the example of one of such approaches to the sociological poetics of the “Bakhtin’s circle”, the author substantiates the possibility of creating an interdisciplinary classification of contextual approaches. That classification may include scientific developments of different years and research fields, including: philosophical hermeneutics, a number of approaches to the Russian and foreign literary theory (M.M. Bakhtin, Yu.M. Lotman, B.M. Eichenbaum, F. Moretti, A. Compagnon, etc.), intellectual history, discourse analysis, etc.

Novel Chemotherapeutic Agents - The Contribution of Scorpionates

2020 ◽  
Vol 26 (41) ◽  
pp. 7452-7475 ◽  
Author(s):  
Marta A. Andrade ◽  
Luísa M.D.R.S. Martins
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Bioinorganic Chemistry ◽  
Chemotherapeutic Agents ◽  
Great Role ◽  
Anticancer Properties ◽  
Scorpionate Ligands

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)

2013 ◽  
Vol 85 (8) ◽  
pp. 1725-1758 ◽  
Author(s):  
Derek R. Buckle ◽  
Paul W. Erhardt ◽  
C. Robin Ganellin ◽  
Toshi Kobayashi ◽  
Thomas J. Perun ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Human Genome ◽  
Human Genome Project ◽  
Medicinal Chemistry ◽  
Genome Project ◽  
Scientific Disciplines ◽  
New Concepts ◽  
Essential Components ◽  
The Many ◽  
The Human Genome Project

The evolution that has taken place in medicinal chemistry practice as a result of major advances in genomics and molecular biology arising from the Human Genome Project has carried with it an extensive additional working vocabulary that has become both integrated and essential terminology for the medicinal chemist. Some of this augmented terminology has been adopted from the many related and interlocked scientific disciplines with which the modern medicinal chemist must be conversant, but many other terms have been introduced to define new concepts and ideas as they have arisen. In this supplementary Glossary, we have attempted to collate and define many of the additional terms that are now considered to be essential components of the medicinal chemist’s expanded repertoire.

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