Correlation between molecular orbital distributions in drug-receptor interaction: Diels-Alder reaction systems and dihydrofolate reductase system.

HIDEO KUBODERA; HIDEAKI UMEYAMA

doi:10.1248/cpb.35.4377

Correlation between molecular orbital distributions in drug-receptor interaction: Diels-Alder reaction systems and dihydrofolate reductase system.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.35.4377 ◽

1987 ◽

Vol 35 (11) ◽

pp. 4377-4394

Author(s):

HIDEO KUBODERA ◽

HIDEAKI UMEYAMA

Keyword(s):

Molecular Orbital ◽

Dihydrofolate Reductase ◽

Alder Reaction ◽

Diels Alder ◽

Receptor Interaction ◽

Reaction Systems ◽

Diels Alder Reaction ◽

Drug Receptor ◽

Drug Receptor Interaction

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Correlation between molecular orbital distributions in the intermolecular interaction: Diels-alder reaction systems.

Journal of Synthetic Organic Chemistry Japan ◽

10.5059/yukigoseikyokaishi.45.1073 ◽

1987 ◽

Vol 45 (11) ◽

pp. 1073-1086

Author(s):

Hideo KUBODERA ◽

Hideaki UMEYAMA

Keyword(s):

Intermolecular Interaction ◽

Molecular Orbital ◽

Alder Reaction ◽

Diels Alder ◽

Reaction Systems ◽

Diels Alder Reaction

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ChemInform Abstract: Solvent Effect as the Result of Frontier Molecular-Orbital Interaction. Part 3. Hetero Diels-Alder Reaction with Inverse Electron Demand Between 4-Arylidenepyrazol-5-ones and Isobutyl Vinyl Ether.

ChemInform ◽

10.1002/chin.198946075 ◽

1989 ◽

Vol 20 (46) ◽

Author(s):

M. BURDISSO ◽

G. DESIMONI ◽

G. FAITA ◽

P. RIGHETTI ◽

G. TACCONI

Keyword(s):

Solvent Effect ◽

Vinyl Ether ◽

Molecular Orbital ◽

Alder Reaction ◽

Diels Alder ◽

Frontier Molecular Orbital ◽

Orbital Interaction ◽

Inverse Electron Demand ◽

Diels Alder Reaction ◽

Electron Demand

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Solvent effect as the result of frontier molecular orbital interaction. VII. The retro-diels-alder reaction.

Tetrahedron ◽

10.1016/s0040-4020(01)88725-1 ◽

1992 ◽

Vol 48 (9) ◽

pp. 1667-1674 ◽

Cited By ~ 21

Author(s):

G. Desimoni ◽

G. Faita ◽

D. Pasini ◽

P.P. Righetti

Keyword(s):

Solvent Effect ◽

Molecular Orbital ◽

Alder Reaction ◽

Diels Alder ◽

Frontier Molecular Orbital ◽

Orbital Interaction ◽

Diels Alder Reaction

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ChemInform Abstract: Solvent Effect as the Result of Frontier Molecular Orbital Interaction. Part 7. The Retro-Diels-Alder Reaction.

ChemInform ◽

10.1002/chin.199225057 ◽

2010 ◽

Vol 23 (25) ◽

pp. no-no

Author(s):

G. DESIMONI ◽

G. FAITA ◽

D. PASINI ◽

P. P. RIGHETTI

Keyword(s):

Solvent Effect ◽

Molecular Orbital ◽

Alder Reaction ◽

Diels Alder ◽

Frontier Molecular Orbital ◽

Orbital Interaction ◽

Diels Alder Reaction

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The Diels-Alder Reaction from the EDA-NOCV Perspective: A Re-Examination of the Frontier Molecular Orbital Model

European Journal of Organic Chemistry ◽

10.1002/ejoc.201800888 ◽

2018 ◽

Vol 2019 (2-3) ◽

pp. 478-485 ◽

Cited By ~ 5

Author(s):

Israel Fernández ◽

Gernot Frenking

Keyword(s):

Molecular Orbital ◽

Alder Reaction ◽

Diels Alder ◽

Frontier Molecular Orbital ◽

Diels Alder Reaction ◽

Molecular Orbital Model

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Solvent effect as the result of frontier molecular-orbital interaction. Part 3. Hetero Diels–Alder reaction with inverse electron demand between 4-arylidenepyrazol-5-ones and isobutyl vinyl ether

Journal of the Chemical Society Perkin Transactions 2 ◽

10.1039/p29890000845 ◽

1989 ◽

pp. 845-850 ◽

Cited By ~ 8

Author(s):

Marina Burdisso ◽

Giovanni Desimoni ◽

Giuseppe Faita ◽

Pierpaolo Righetti ◽

Gianfranco Tacconi

Keyword(s):

Solvent Effect ◽

Vinyl Ether ◽

Molecular Orbital ◽

Alder Reaction ◽

Diels Alder ◽

Frontier Molecular Orbital ◽

Orbital Interaction ◽

Inverse Electron Demand ◽

Diels Alder Reaction ◽

Electron Demand

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Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol

Journal of Medicinal Chemistry ◽

10.1021/jm00251a006 ◽

1974 ◽

Vol 17 (5) ◽

pp. 501-507 ◽

Cited By ~ 27

Author(s):

Carlo Petrongolo ◽

Jacopo Tomasi ◽

Bruno Macchia ◽

Franco Macchia

Keyword(s):

Molecular Orbital ◽

Receptor Interaction ◽

Adrenergic Drugs ◽

Drug Receptor ◽

Drug Receptor Interaction

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ChemInform Abstract: MOLECULAR ORBITAL STUDIES ON THE MECHANISM OF DRUG-RECEPTOR INTERACTION. 2. β-ADRENERGIC DRUGS. AN APPROACH TO EXPLAIN THE ROLE OF THE AROMATIC MOIETY

Chemischer Informationsdienst ◽

10.1002/chin.197816136 ◽

1978 ◽

Vol 9 (16) ◽

Author(s):

C. PETRONGOLO ◽

B. MACCHIA ◽

F. MACCHIA ◽

A. MARTINELLI

Keyword(s):

Molecular Orbital ◽

Receptor Interaction ◽

Aromatic Moiety ◽

Adrenergic Drugs ◽

Drug Receptor ◽

Drug Receptor Interaction

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Continuous flow of nitroso Diels–Alder reaction

Chemical Communications ◽

10.1039/c5cc03458b ◽

2015 ◽

Vol 51 (61) ◽

pp. 12309-12312 ◽

Cited By ~ 12

Author(s):

Erika Nakashima ◽

Hisashi Yamamoto

Keyword(s):

Continuous Flow ◽

Alder Reaction ◽

Diels Alder ◽

Reaction Systems ◽

Diels Alder Reaction ◽

Temperature And Pressure ◽

Flow Reaction ◽

Cyclic Dienes

Our flow reaction systems have provided quantitative yields of nitroso Diels–Alder products with no byproducts in cases of cyclic dienes without temperature and pressure controls.

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ChemInform Abstract: Solvent Effect as the Result of Frontier Molecular Orbital Interaction. Part 4. A Parallel Between Solvent Effect and Acid Catalysis in the Intramolecular Hetero-Diels-Alder Reaction.

ChemInform ◽

10.1002/chin.198926074 ◽

1989 ◽

Vol 20 (26) ◽

Author(s):

A. CORSICO CODA ◽

G. DESIMONI ◽

G. FAITA ◽

P. RIGHETTI ◽

G. TACCONI

Keyword(s):

Solvent Effect ◽

Molecular Orbital ◽

Acid Catalysis ◽

Alder Reaction ◽

Diels Alder ◽

Frontier Molecular Orbital ◽

Orbital Interaction ◽

Diels Alder Reaction

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