Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol

1974 ◽  
Vol 17 (5) ◽  
pp. 501-507 ◽  
Author(s):  
Carlo Petrongolo ◽  
Jacopo Tomasi ◽  
Bruno Macchia ◽  
Franco Macchia
Keyword(s):  
Molecular Orbital ◽  
Receptor Interaction ◽  
Adrenergic Drugs ◽  
Drug Receptor ◽  
Drug Receptor Interaction

scholarly journals Computer-Controlled Muscle Paralysis with Atracurium in the Sheep

1986 ◽  
Vol 14 (1) ◽  
pp. 7-11 ◽  
Author(s):  
D. G. Lampard ◽  
W. A. Brown ◽  
N. M. Cass ◽  
K. C. Ng
Keyword(s):  
Infusion Rate ◽  
Recovery Time ◽  
Neuromuscular Transmission ◽  
Receptor Interaction ◽  
Muscle Paralysis ◽  
Observed Behaviour ◽  
Integrated Electromyogram ◽  
Computer Controlled ◽  
Drug Receptor ◽  
Drug Receptor Interaction

Paralysis was maintained in sheep by computer-controlled infusion of atracurium, using the integrated electromyogram as a measure of neuromuscular transmission. A number of experiments were conducted to ascertain the average infusion rate required to achieve a given level of paralysis for one hour. Each experiment yielded a point on a plot of paralysis versus infusion rate. A dose-response curve based upon a simple model of drug receptor interaction at the neuromuscular junction was fitted to the experimental points by least squares and is able to provide a useful explanation of clinically observed behaviour. The recovery time was also measured in each experiment and plotted against both prior level of paralysis and prior average infusion rate.

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