ChemInform Abstract: MOLECULAR ORBITAL STUDIES ON THE MECHANISM OF DRUG-RECEPTOR INTERACTION. 2. β-ADRENERGIC DRUGS. AN APPROACH TO EXPLAIN THE ROLE OF THE AROMATIC MOIETY

1978 ◽  
Vol 9 (16) ◽  
Author(s):  
C. PETRONGOLO ◽  
B. MACCHIA ◽  
F. MACCHIA ◽  
A. MARTINELLI
Keyword(s):  
Molecular Orbital ◽  
Receptor Interaction ◽  
Aromatic Moiety ◽  
Adrenergic Drugs ◽  
Drug Receptor ◽  
Drug Receptor Interaction

scholarly journals Integrated Role of Nanotechnology and Pharmacogenetics in Diagnosis and Treatment of Diseases

2021 ◽  
Author(s):  
Ruchi Chawla ◽  
Varsha Rani ◽  
Mohini Mishra ◽  
Krishan Kumar
Keyword(s):  
Dosage Form ◽  
Drug Response ◽  
Research Area ◽  
Diagnosis And Treatment ◽  
Receptor Interaction ◽  
Disease Etiology ◽  
Drug Receptor ◽  
Treatment And Diagnosis ◽  
Drug Receptor Interaction

“One size fits all” is an erroneous paradigm in drug delivery, due to side effects/adverse effects and variability observed in drug response. The variability is a result of geneotypic variations (variability in genomic constitution) which is studied in the branch of science called Pharmacogenomics. The variability in drug response is studied by multigene analysis or profiling of whole-genome single nucleotide polymorphism (SNP) and is recorded in terms of the pharmacokinetic (absorption, distribution, metabolism and elimination) and pharmacodynamic (drug-receptor interaction, immune response, etc.) response of the drug. Therefore, a foray into this research area can provide valuable information for designing of drug therapies, identifying disease etiology, therapeutic targets and biomarkers for application in treatment and diagnosis of diseases. Lately, with the integration of pharmacogenomics and nanotechnology, a new facade for the diagnosis and treatment of diseases has opened up, and the prescription pattern of drugs has moved to pharmacotyping (individualized dose and dosage-form adjusted therapy) using nanoplatforms like nanobioconjugates, nanotheranostics, etc.

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