Synthesis, Structure, and Reversible Deprotonation of a Half-sandwich Iridium Complex Bearing a Chelating Oxime Ligand

Megumi Watanabe; Yohei Kashiwame; Shigeki Kuwata; Takao Ikariya

doi:10.1246/cl.2010.758

Catalytic reactivity of an iridium complex with a proton responsive N-donor ligand in CO2 hydrogenation to formate

RSC Advances ◽

10.1039/c7ra12343d ◽

2018 ◽

Vol 8 (3) ◽

pp. 1346-1350 ◽

Cited By ~ 10

Author(s):

Gunniya Hariyanandam Gunasekar ◽

Yeahsel Yoon ◽

Il-hyun Baek ◽

Sungho Yoon

Keyword(s):

Structural Instability ◽

Co2 Hydrogenation ◽

Catalytic Cycle ◽

Iridium Complex ◽

Donor Ligand ◽

Excellent Activity ◽

Catalytic Reactivity ◽

Half Sandwich

A bibenzimidazole ligated half-sandwich Ir complex [Cp*Ir(BiBzImH2)Cl]Cl shows superior activity than that of its bipyridine counterpart. Owing to the structural instability, the initial excellent activity of [Cp*Ir(BiBzImH2)Cl]Cl was reduced when catalytic cycle proceeds.

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Dual Catalytic Cycle of H2 and H2O Oxidations by a Half-Sandwich Iridium Complex: A Theoretical Study

Inorganic Chemistry ◽

10.1021/acs.inorgchem.9b00307 ◽

2019 ◽

Vol 58 (11) ◽

pp. 7274-7284 ◽

Cited By ~ 2

Author(s):

Kei Ikeda ◽

Yuta Hori ◽

Muhammad Haris Mahyuddin ◽

Yoshihito Shiota ◽

Aleksandar Staykov ◽

...

Keyword(s):

Theoretical Study ◽

Catalytic Cycle ◽

Iridium Complex ◽

Half Sandwich

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Oxygen Atom Transfer to a Half-Sandwich Iridium Complex: Clean Oxidation Yielding a Molecular Product

Journal of the American Chemical Society ◽

10.1021/ja413023f ◽

2014 ◽

Vol 136 (10) ◽

pp. 3981-3994 ◽

Cited By ~ 25

Author(s):

Christopher R. Turlington ◽

Peter S. White ◽

Maurice Brookhart ◽

Joseph L. Templeton

Keyword(s):

Oxygen Atom ◽

Iridium Complex ◽

Atom Transfer ◽

Oxygen Atom Transfer ◽

Molecular Product ◽

Half Sandwich

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Sequential Nitrene Transfers to an Organometallic Half-Sandwich Iridium Complex

Organometallics ◽

10.1021/acs.organomet.5b00717 ◽

2015 ◽

Vol 34 (20) ◽

pp. 4810-4812 ◽

Cited By ~ 1

Author(s):

Christopher R. Turlington ◽

Peter S. White ◽

Maurice Brookhart ◽

Joseph L. Templeton

Keyword(s):

Iridium Complex ◽

Half Sandwich

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Chemoselective and efficient catalytic hydrogenation of furfural by iridium and ruthenium half-sandwich complexes

New Journal of Chemistry ◽

10.1039/d0nj01811b ◽

2020 ◽

Vol 44 (22) ◽

pp. 9382-9390 ◽

Cited By ~ 2

Author(s):

Novisi K. Oklu ◽

Banothile C. E. Makhubela

Keyword(s):

Catalytic Hydrogenation ◽

Furfuryl Alcohol ◽

Hydrogen Gas ◽

Iridium Complex ◽

Selective Synthesis ◽

Sandwich Complexes ◽

Half Sandwich

A recyclable homogeneous iridium complex for the selective synthesis of furfuryl alcohol from furfural without additional solvent and hydrogen gas.

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Synthesis of a Half-Sandwich Hydroxidoiridium(III) Complex Bearing a Nonprotic N-Sulfonyldiamine Ligand and Its Transformations Triggered by the Brønsted Basicity

Inorganics ◽

10.3390/inorganics7100125 ◽

2019 ◽

Vol 7 (10) ◽

pp. 125

Author(s):

Shoko Kamezaki ◽

Yoshihito Kayaki ◽

Shigeki Kuwata ◽

Takao Ikariya

Keyword(s):

Nmr Spectroscopy ◽

Elemental Analysis ◽

Hydride Transfer ◽

Iridium Complex ◽

Acetone Cyanohydrin ◽

X Ray ◽

Cyanide Anion ◽

X Ray Crystallography ◽

Chloride Ligand ◽

Half Sandwich

Synthesis and reactivities of a new mononuclear hydroxidoiridium(III) complex with a pentamethylcyclopentadienyl (Cp*) ligand are reported. The hydroxido ligand was introduced into an iridium complex having a nonprotic amine chelate derived from N-mesyl-N’,N’-dimethylethylenediamine by substitution of the chloride ligand using KOH. The resulting hydroxidoiridium complex was characterized by NMR spectroscopy, elemental analysis, and X-ray crystallography. The hydroxido complex was able to deprotonate benzamide and acetonitrile, and showed an ability to accept a hydride from 2-propanol to generate the corresponding hydrido complex quantitatively. In the reaction with mandelonitrile, a cyanide anion was transferred to the iridium center in preference to the hydride transfer. The cyanidoiridium complex was also identified in the reaction with acetone cyanohydrin, and could serve as catalyst species in the transfer hydrocyanation of benzaldehyde.

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Cyclometalated Half-Sandwich Iridium Complex for Catalytic Hydrogenation of Imines and Quinolines

Organometallics ◽

10.1021/acs.organomet.8b00553 ◽

2018 ◽

Vol 37 (21) ◽

pp. 3883-3892 ◽

Cited By ~ 6

Author(s):

Zi-Jian Yao ◽

Nan Lin ◽

Xin-Chao Qiao ◽

Jing-Wei Zhu ◽

Wei Deng

Keyword(s):

Catalytic Hydrogenation ◽

Iridium Complex ◽

Half Sandwich

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Regioselective B–H/C–H activation and metal–metal bond formation induced by half-sandwich metals complexes at hydroxy-substituted o-carboranes

Dalton Transactions ◽

10.1039/c8dt03104e ◽

2018 ◽

Vol 47 (38) ◽

pp. 13641-13646 ◽

Cited By ~ 5

Author(s):

Shu-Ting Guo ◽

Peng-Fei Cui ◽

Yang Gao ◽

Guo-Xin Jin

Keyword(s):

Bond Formation ◽

Iridium Complex ◽

Metal Bond ◽

Metal Metal ◽

Half Sandwich

A binuclear iridium complex, (Cp2*Ir2(CH2O)C2B10H8) (6), with a unique metal–metal bond has been synthesized and fully characterized.

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Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

10.26434/chemrxiv.12155178.v1 ◽

2020 ◽

Author(s):

Sofia Alexandra Milheiro ◽

Joana Gonçalves ◽

Ricardo Lopes ◽

Margarida Madureira ◽

Lis Lobo ◽

...

Keyword(s):

Mammalian Cells ◽

Blood Stage ◽

Nuclear Accumulation ◽

Selective Absorption ◽

Asexual Parasite ◽

Single Digit ◽

Liver Stage ◽

Dual Stage ◽

Fluorescent Compounds ◽

Half Sandwich

<a>A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds of general formula [(</a>η5-C5R5)Ru(PPh3)(N-N)][PF6], a scaffold hitherto unfeatured in the toolbox of antiplasmodials, was screened for activity against the blood stage of CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 Plasmodium falciparum strains, and the liver stage of P. berghei. The best performing compounds displayed dual-stage activity, with single-digit nM IC50 values against blood stage malaria parasites, nM activity against liver stage parasites, and residual cytotoxicity against mammalian cells (HepG2, Huh7). Parasitic absorption/distribution of 7-nitrobenzoxadiazole-appended fluorescent compounds Ru4 and Ru5 was investigated by confocal fluorescence microscopy, revealing parasite-selective absorption in infected erythrocytes and nuclear accumulation of both compounds. The lead compound Ru2 impaired asexual parasite differentiation, exhibiting fast parasiticidal activity against both ring and trophozoite stages of a synchronized P. falciparum 3D7 strain. These results point to cyclopentadienylruthenium(II) complexes as a highly promising chemotype for the development of dual-stage antiplasmodials.

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