scholarly journals Mixed Adsorbed Film and Micelles of Sodium Taurocholate and Sodium Taurodeoxycholate

1991 ◽  
Vol 64 (9) ◽  
pp. 2691-2694 ◽  
Author(s):  
Atsunori Wada ◽  
Norihiro Matubayasi ◽  
Kinsi Motomura
Keyword(s):  
Sodium Taurocholate ◽  
Adsorbed Film ◽  
Sodium Taurodeoxycholate

Behaviors of Sodium Taurocholate and Sodium Taurodeoxycholate in Binary Mixed Micelles of Bile Salt and Nonionic Surfactant

Langmuir ◽  
1996 ◽  
Vol 12 (23) ◽  
pp. 5536-5540 ◽  
Author(s):  
K. Suzuki ◽  
T. Hasegawa ◽  
Y. Takamura ◽  
K. Takahashi ◽  
H. Asano ◽  
...  
Keyword(s):  
Bile Salt ◽  
Nonionic Surfactant ◽  
Mixed Micelles ◽  
Sodium Taurocholate ◽  
Sodium Taurodeoxycholate

scholarly journals Enzymic hydrolysis of sphingomyelin in the presence of bile salts

1980 ◽  
Vol 185 (3) ◽  
pp. 749-754 ◽  
Author(s):  
S Yedgar ◽  
S Gatt
Keyword(s):  
Bile Salt ◽  
Bile Salts ◽  
Sodium Taurocholate ◽  
Absolute Concentration ◽  
Mixed Aggregates ◽  
Sodium Taurodeoxycholate ◽  
Rate Of Hydrolysis ◽  
The Absolute ◽  
Hydrolysis Of ◽  
Low Activity

Sphingomyelin in mixed dispersion with bile salts was hydrolysed by the solubilized sphingomyelinase of rat brain lysosomes. In parallel studies, physical properties of these dispersions were determined. The kinetic curves that described the rate of hydrolysis as a function of increasing concentrations of bile salt were multiphasic. A region of very low activity was followed by an ascending portion, a peak, a descending portion, a trough and a second ascending portion. The positions of the initiation points, peaks and troughs were found to be a function of the respective ratios of the bile salt to sphingomyelin for the detergent sodium taurodeoxycholate, but of the absolute concentration of the detergent for sodium taurocholate. Turbidity studies suggested that hydrolysis of sphingomyelin begins at a bile salt concentration that solubilizes the lipid and incorporates it into a mixed micelle with the detergent. Ultracentrifugation studies suggested that the sizes of the mixed aggregates of detergent and lipid were a function of the ratio of taurodeoxycholate to sphingomyelin, but of the absolute concentration of the bile salt, for sodium taurocholate.

scholarly journals Importance of Bile Composition for Diagnosis of Biliary Obstructions

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7279
Author(s):  
Łukasz Krupa ◽  
Robert Staroń ◽  
Dorota Dulko ◽  
Natalia Łozińska ◽  
Alan R. Mackie ◽  
...  
Keyword(s):  
Biliary Obstruction ◽  
Bile Salts ◽  
Serum Bilirubin ◽  
Sodium Taurocholate ◽  
Roc Curves ◽  
Sodium Cholate ◽  
Serum Markers ◽  
Sodium Taurodeoxycholate ◽  
Malignant Changes ◽  
Bile Cholesterol

Determination of the cause of a biliary obstruction is often inconclusive from serum analysis alone without further clinical tests. To this end, serum markers as well as the composition of bile of 74 patients with biliary obstructions were determined to improve the diagnoses. The samples were collected from the patients during an endoscopic retrograde cholangiopancreatography (ERCP). The concentration of eight bile salts, specifically sodium cholate, sodium glycocholate, sodium taurocholate, sodium glycodeoxycholate, sodium chenodeoxycholate, sodium glycochenodeoxycholate, sodium taurodeoxycholate, and sodium taurochenodeoxycholate as well as bile cholesterol were determined by HPLC-MS. Serum alanine aminotransferase (ALT), aspartate transaminase (AST), and bilirubin were measured before the ERCP. The aim was to determine a diagnostic factor and gain insights into the influence of serum bilirubin as well as bile salts on diseases. Ratios of conjugated/unconjugated, primary/secondary, and taurine/glycine conjugated bile salts were determined to facilitate the comparison to literature data. Receiver operating characteristic (ROC) curves were determined, and the cut-off values were calculated by determining the point closest to (0,1). It was found that serum bilirubin was a good indicator of the type of biliary obstruction; it was able to differentiate between benign obstructions such as choledocholithiasis (at the concentration of >11 µmol/L) and malignant changes such as pancreatic neoplasms or cholangiocarcinoma (at the concentration of >59 µmol/L). In addition, it was shown that conjugated/unconjugated bile salts confirm the presence of an obstruction. With lower levels of conjugated/unconjugated bile salts the possibility for inflammation and, thus, neoplasms increase.

scholarly journals ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems

2020 ◽  
Vol 70 (12) ◽  
pp. 4354-4359
Keyword(s):  
Electron Spin Resonance ◽  
Bile Salts ◽  
Esr Spectroscopy ◽  
Sodium Dodecyl ◽  
Sodium Taurocholate ◽  
Spin Probes ◽  
Sds Micelles ◽  
Membrane Mimetic ◽  
Spin Resonance ◽  
Sodium Taurodeoxycholate

The location of mitoxantrone molecule in micelles formed by bile salts (sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC)) and sodium dodecyl sulfate (SDS) have been investigated by electron spin resonance (ESR) spectroscopy, using three doxylstearic acid probes (5-, 12- and 16-doxylstearic acid abbreviated as 5-DSA, 12-DSA and 16-DSA). The analysis of ESR parameters of these spin probes evidenced slower dynamics induced by mitoxantrone that vary in the following order: 12-DSA > 5-DSA > 16-DSA for both bile salts micelles and 5-DSA > 12-DSA > 16-DSA for SDS micelles. The ESR parameters are slightly sensitive to variation of pH. These results indicate that the spin probes target different regions in these aggregates. Keywords: mitoxantrone, bile salts micelles, SDS micelles, ESR spectroscopy

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