scholarly journals Synthetic Studies of Amino Acids by the Use of Copper(II) Complex. III. Syntheses of Several 2-Amino-2-deoxyaldonic Acids by the Use of Bisglycinato- andN-Pyruvylideneglycinatoaquocopper(II)

1973 ◽  
Vol 46 (3) ◽  
pp. 981-985 ◽  
Author(s):  
Shohji Ohdan ◽  
Toshiro Okamoto ◽  
Sadao Maeda ◽  
Tetsuya Ichikawa ◽  
Younosuke Araki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Complex Iii ◽  
Synthetic Studies

scholarly journals Monitoring mitochondrial translation by pulse SILAC

2021 ◽  
Author(s):  
Koshi Imami ◽  
Matthias Selbach ◽  
Yasushi Ishihama
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Membrane Proteins ◽  
Translational Regulation ◽  
Isotope Labeling ◽  
Protein Complexes ◽  
Complex Iii ◽  
Mitochondrial Translation ◽  
Mitochondrial Ribosomes ◽  
Hydrophobic Nature

SummaryMitochondrial ribosomes are specialized to translate the 13 membrane proteins encoded in the mitochondrial genome, but it is challenging to quantify mitochondrial translation products due to their hydrophobic nature. Here, we introduce a proteomic method that combines biochemical isolation of mitochondria with pulse stable isotope labeling by amino acids in cell culture (pSILAC). Our method provides the highest protein coverage (quantifying 12 out of the 13 inner-membrane proteins; average 2-fold improvement over previous studies) with the shortest measurement time. We applied this method to uncover the global picture of (post)translational regulation of both mitochondrial- and nuclear-encoded proteins involved in the assembly of protein complexes that mediate oxidative phosphorylation (OXPHOS). The results allow us to infer the assembly order of complex components and/or partners, as exemplified by complex III. This method should be applicable to study mitochondrial translation programs in many contexts, including oxidative stress and mitochondrial disease.

Synthetic studies of novel ninhydrin analogs

2001 ◽  
Vol 79 (11) ◽  
pp. 1632-1654 ◽  
Author(s):  
Richard R Hark ◽  
Diane B Hauze ◽  
Olga Petrovskaia ◽  
Madeleine M Joullié
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Latent Fingerprints ◽  
Cross Coupling Reactions ◽  
Essential Tool ◽  
Porous Surfaces ◽  
Synthetic Studies ◽  
Sulfur Containing

Ninhydrin is an essential tool in the analysis of amino acids, peptides, and proteins, and the preferred reagent for the detection of latent fingerprints on porous surfaces. The goal of this investigation was to prepare ninhydrin analogs with enhanced chromogenic and fluorogenic properties. Target compounds included structures with extended conjugation and (or) with the presence of sulfur-containing moieties. We have devised general convergent routes for novel heterocyclic and aryl-substituted ninhydrin analogs for use as reagents for amino acid detection.Key words: ninhydrin analogs, synthesis, ketals, Suzuki cross-coupling reactions, Stille cross-coupling reactions.

scholarly journals Amino acids and peptides. IX. Synthetic studies on Leu-enkephalin analogues containing a ureylene bond.

1988 ◽  
Vol 36 (5) ◽  
pp. 1766-1771 ◽  
Author(s):  
KOICHI KAWASAKI ◽  
MITSUKO MAEDA ◽  
JOE WATANABE ◽  
HIROSHI KANETO
Keyword(s):  
Amino Acids ◽  
Enkephalin Analogues ◽  
Synthetic Studies

Synthetic studies in unnatural cyclic amino acids

1979 ◽  
Vol 44 (14) ◽  
pp. 2487-2491 ◽  
Author(s):  
Ving J. Lee ◽  
R. B. Woodward
Keyword(s):  
Amino Acids ◽  
Synthetic Studies ◽  
Cyclic Amino Acids
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