scholarly journals The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse

2013 ◽  
Vol 126 (17) ◽  
pp. 3927-3938 ◽  
Author(s):  
A. Vasileva ◽  
K. M. Hopkins ◽  
X. Wang ◽  
M. M. Weisbach ◽  
R. A. Friedman ◽  
...  
Keyword(s):  
Dna Damage ◽  
Male Meiosis ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein

The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse

Development ◽  
2013 ◽  
Vol 140 (19) ◽  
pp. e1907-e1907
Author(s):  
Ana Vasileva ◽  
Kevin M. Hopkins ◽  
Xiangyuan Wang ◽  
Melissa M. Weisbach ◽  
Richard A. Friedman ◽  
...  
Keyword(s):  
Dna Damage ◽  
Male Meiosis ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein

scholarly journals The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease

Cell Cycle ◽  
2012 ◽  
Vol 11 (10) ◽  
pp. 1918-1928 ◽  
Author(s):  
Erin K. Daugherity ◽  
Gabriel Balmus ◽  
Ahmed Al Saei ◽  
Elizabeth S. Moore ◽  
Delbert Abi Abdallah ◽  
...  
Keyword(s):  
Dna Damage ◽  
Liver Disease ◽  
Mouse Model ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dna Damage Checkpoint ◽  
Alcoholic Fatty Liver ◽  
Checkpoint Protein ◽  
Hepatocellular Apoptosis ◽  
Alcoholic Fatty Liver Disease

TORC1 regulates the DNA damage checkpoint via checkpoint protein levels

2019 ◽  
Vol 510 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Ikuko Miyamoto ◽  
Ryota Ozaki ◽  
Kazuyuki Yamaguchi ◽  
Kaori Yamamoto ◽  
Atsuki Kaneko ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein ◽  
Protein Levels

scholarly journals Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguard

2020 ◽  
Author(s):  
Natalie R Powers ◽  
Beth L Dumont ◽  
Chihiro Emori ◽  
Raman Akinyanju Lawal ◽  
Catherine Brunton ◽  
...  
Keyword(s):  
Dna Damage ◽  
Meiotic Recombination ◽  
Genetic Background ◽  
Dna Damage Checkpoint ◽  
Human Female ◽  
Female Meiosis ◽  
Checkpoint Protein ◽  
Recombination System ◽  
Specific Regulation ◽  
Female Specific

AbstractIn many mammals, genomic sites for recombination are determined by histone methyltransferase PRMD9. Mice lacking PRDM9 are infertile, but instances of fertility or semi-fertility in the absence of PRDM9 have been reported in mice, canines and a human female. Such findings raise the question of how the loss of PRDM9 is circumvented to maintain reproductive fitness. We show that genetic background and sex-specific modifiers can obviate the requirement for PRDM9 in mice. Specifically, the meiotic DNA damage checkpoint protein CHK2 acts as a modifier allowing female-specific fertility in the absence of PRDM9. We also report that in the absence of PRDM9, a PRDM9-independent recombination system is compatible with female meiosis and fertility, suggesting sex-specific regulation of meiotic recombination, a finding with implications for speciation.One Sentence SummarySex-specific modulation of a meiotic DNA damage checkpoint limits the requirement for PRDM9 in mammalian fertility.

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