scholarly journals Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26

2017 ◽  
Vol 292 (20) ◽  
pp. 8149-8157 ◽  
Author(s):  
Kasper Røjkjær Andersen
Keyword(s):  
Crystal Structure ◽  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein

scholarly journals The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease

Cell Cycle ◽  
2012 ◽  
Vol 11 (10) ◽  
pp. 1918-1928 ◽  
Author(s):  
Erin K. Daugherity ◽  
Gabriel Balmus ◽  
Ahmed Al Saei ◽  
Elizabeth S. Moore ◽  
Delbert Abi Abdallah ◽  
...  
Keyword(s):  
Dna Damage ◽  
Liver Disease ◽  
Mouse Model ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dna Damage Checkpoint ◽  
Alcoholic Fatty Liver ◽  
Checkpoint Protein ◽  
Hepatocellular Apoptosis ◽  
Alcoholic Fatty Liver Disease

scholarly journals Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp

2019 ◽  
Vol 295 (4) ◽  
pp. 899-904
Author(s):  
Kodai Hara ◽  
Nao Iida ◽  
Ryota Tamafune ◽  
Eiji Ohashi ◽  
Hitomi Sakurai ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Damage ◽  
Enzymatic Activities ◽  
The Other ◽  
Nuclear Proteins ◽  
Dna Damage Checkpoint ◽  
Specific Interactions ◽  
Related Protein ◽  
Biological Functions ◽  
Central Pore

DNA clamp, a highly conserved ring-shaped protein, binds dsDNA within its central pore. Also, DNA clamp interacts with various nuclear proteins on its front, thereby stimulating their enzymatic activities and biological functions. It has been assumed that the DNA clamp is a functionally single-faced ring from bacteria to humans. Here, we report the crystal structure of the heterotrimeric RAD9-RAD1-HUS1 (9-1-1) checkpoint clamp bound to a peptide of RHINO, a recently identified cancer-related protein that interacts with 9-1-1 and promotes activation of the DNA damage checkpoint. This is the first structure of 9-1-1 bound to its partner. The structure reveals that RHINO is unexpectedly bound to the edge and around the back of the 9-1-1 ring through specific interactions with the RAD1 subunit of 9-1-1. Our finding indicates that 9-1-1 is a functionally double-faced DNA clamp.

TORC1 regulates the DNA damage checkpoint via checkpoint protein levels

2019 ◽  
Vol 510 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Ikuko Miyamoto ◽  
Ryota Ozaki ◽  
Kazuyuki Yamaguchi ◽  
Kaori Yamamoto ◽  
Atsuki Kaneko ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein ◽  
Protein Levels

The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse

Development ◽  
2013 ◽  
Vol 140 (19) ◽  
pp. e1907-e1907
Author(s):  
Ana Vasileva ◽  
Kevin M. Hopkins ◽  
Xiangyuan Wang ◽  
Melissa M. Weisbach ◽  
Richard A. Friedman ◽  
...  
Keyword(s):  
Dna Damage ◽  
Male Meiosis ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein

scholarly journals Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguard

2020 ◽  
Author(s):  
Natalie R Powers ◽  
Beth L Dumont ◽  
Chihiro Emori ◽  
Raman Akinyanju Lawal ◽  
Catherine Brunton ◽  
...  
Keyword(s):  
Dna Damage ◽  
Meiotic Recombination ◽  
Genetic Background ◽  
Dna Damage Checkpoint ◽  
Human Female ◽  
Female Meiosis ◽  
Checkpoint Protein ◽  
Recombination System ◽  
Specific Regulation ◽  
Female Specific

AbstractIn many mammals, genomic sites for recombination are determined by histone methyltransferase PRMD9. Mice lacking PRDM9 are infertile, but instances of fertility or semi-fertility in the absence of PRDM9 have been reported in mice, canines and a human female. Such findings raise the question of how the loss of PRDM9 is circumvented to maintain reproductive fitness. We show that genetic background and sex-specific modifiers can obviate the requirement for PRDM9 in mice. Specifically, the meiotic DNA damage checkpoint protein CHK2 acts as a modifier allowing female-specific fertility in the absence of PRDM9. We also report that in the absence of PRDM9, a PRDM9-independent recombination system is compatible with female meiosis and fertility, suggesting sex-specific regulation of meiotic recombination, a finding with implications for speciation.One Sentence SummarySex-specific modulation of a meiotic DNA damage checkpoint limits the requirement for PRDM9 in mammalian fertility.

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