scholarly journals Mediator of DNA Damage Checkpoint Protein 1

2020 ◽  
Author(s):  
Keyword(s):  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein

scholarly journals The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease

Cell Cycle ◽  
2012 ◽  
Vol 11 (10) ◽  
pp. 1918-1928 ◽  
Author(s):  
Erin K. Daugherity ◽  
Gabriel Balmus ◽  
Ahmed Al Saei ◽  
Elizabeth S. Moore ◽  
Delbert Abi Abdallah ◽  
...  
Keyword(s):  
Dna Damage ◽  
Liver Disease ◽  
Mouse Model ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dna Damage Checkpoint ◽  
Alcoholic Fatty Liver ◽  
Checkpoint Protein ◽  
Hepatocellular Apoptosis ◽  
Alcoholic Fatty Liver Disease

TORC1 regulates the DNA damage checkpoint via checkpoint protein levels

2019 ◽  
Vol 510 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Ikuko Miyamoto ◽  
Ryota Ozaki ◽  
Kazuyuki Yamaguchi ◽  
Kaori Yamamoto ◽  
Atsuki Kaneko ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein ◽  
Protein Levels

The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse

Development ◽  
2013 ◽  
Vol 140 (19) ◽  
pp. e1907-e1907
Author(s):  
Ana Vasileva ◽  
Kevin M. Hopkins ◽  
Xiangyuan Wang ◽  
Melissa M. Weisbach ◽  
Richard A. Friedman ◽  
...  
Keyword(s):  
Dna Damage ◽  
Male Meiosis ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein

scholarly journals Sexual dimorphism in the meiotic requirement for PRDM9: a mammalian evolutionary safeguard

2020 ◽  
Author(s):  
Natalie R Powers ◽  
Beth L Dumont ◽  
Chihiro Emori ◽  
Raman Akinyanju Lawal ◽  
Catherine Brunton ◽  
...  
Keyword(s):  
Dna Damage ◽  
Meiotic Recombination ◽  
Genetic Background ◽  
Dna Damage Checkpoint ◽  
Human Female ◽  
Female Meiosis ◽  
Checkpoint Protein ◽  
Recombination System ◽  
Specific Regulation ◽  
Female Specific

AbstractIn many mammals, genomic sites for recombination are determined by histone methyltransferase PRMD9. Mice lacking PRDM9 are infertile, but instances of fertility or semi-fertility in the absence of PRDM9 have been reported in mice, canines and a human female. Such findings raise the question of how the loss of PRDM9 is circumvented to maintain reproductive fitness. We show that genetic background and sex-specific modifiers can obviate the requirement for PRDM9 in mice. Specifically, the meiotic DNA damage checkpoint protein CHK2 acts as a modifier allowing female-specific fertility in the absence of PRDM9. We also report that in the absence of PRDM9, a PRDM9-independent recombination system is compatible with female meiosis and fertility, suggesting sex-specific regulation of meiotic recombination, a finding with implications for speciation.One Sentence SummarySex-specific modulation of a meiotic DNA damage checkpoint limits the requirement for PRDM9 in mammalian fertility.

scholarly journals Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

1998 ◽  
Vol 17 (14) ◽  
pp. 4199-4209 ◽  
Author(s):  
Vera Paciotti ◽  
Giovanna Lucchini ◽  
Paolo Plevani ◽  
Maria Pia Longhese
Keyword(s):  
Dna Damage ◽  
Dna Damage Checkpoint ◽  
Checkpoint Protein
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