scholarly journals Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

2012 ◽  
Vol 5 (4) ◽  
pp. 444-456 ◽  
Author(s):  
R. Robinson ◽  
V. A. Barathi ◽  
S. S. Chaurasia ◽  
T. Y. Wong ◽  
T. S. Kern
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models ◽  
Molecular Approaches

scholarly journals Animal Models of Diabetic Retinopathy

2017 ◽  
Vol 17 (10) ◽  
Author(s):  
Ana Maria Olivares ◽  
Kristen Althoff ◽  
Gloria Fanghua Chen ◽  
Siqi Wu ◽  
Margaux A. Morrisson ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models

Animal Models of Diabetic Retinopathy

2015 ◽  
Vol 40 (8) ◽  
pp. 761-771 ◽  
Author(s):  
Xiaoyan Jiang ◽  
Lizhu Yang ◽  
Yan Luo
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models

Animal Models of Diabetic Retinopathy

2009 ◽  
pp. 113-138 ◽  
Author(s):  
Adrian M. Timmers ◽  
Casey M. Miller ◽  
Li Zhu
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models

scholarly journals Mesenchymal marker expression is elevated in Müller cells exposed to high glucose and in animal models of diabetic retinopathy

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 4582-4594 ◽  
Author(s):  
Ti Zhou ◽  
Di Che ◽  
Yuqing Lan ◽  
Zhenzhen Fang ◽  
Jinye Xie ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models ◽  
High Glucose ◽  
Müller Cells ◽  
Muller Cells ◽  
Mesenchymal Marker ◽  
Marker Expression

scholarly journals Animal Models of Diabetic Retinopathy: Summary and Comparison

2013 ◽  
Vol 2013 ◽  
pp. 1-29 ◽  
Author(s):  
Angela Ka Wai Lai ◽  
Amy C. Y. Lo
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models ◽  
Chronic Exposure ◽  
Diabetic Patients ◽  
Pathophysiological Mechanism ◽  
Pathological Findings ◽  
Mechanistic Studies ◽  
Single Model ◽  
Advantages And Disadvantages ◽  
Functional Aspects

Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide. Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). In this review, we summarize the existing protocols to induce diabetes using STZ. We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models. The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed. Until now, there is no single model that displays all the clinical features of DR as seen in human. Yet, with the understanding of the pathological findings in these animal models, researchers can select the most suitable models for mechanistic studies or drug screening.

Lipoic acid in animal models and clinical use in diabetic retinopathy

2013 ◽  
Vol 14 (13) ◽  
pp. 1829-1838 ◽  
Author(s):  
Marcella Nebbioso ◽  
Federica Pranno ◽  
Nicola Pescosolido
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models ◽  
Lipoic Acid ◽  
Clinical Use

scholarly journals Botanical Compounds: Effects on Major Eye Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Tuan-Phat Huynh ◽  
Shivani N. Mann ◽  
Nawajes A. Mandal
Keyword(s):  
Diabetic Retinopathy ◽  
Animal Models ◽  
Retinitis Pigmentosa ◽  
Cell Cultures ◽  
Clinical Studies ◽  
Eye Diseases ◽  
Age Related Macular Degeneration ◽  
Ocular Diseases ◽  
Beneficial Effects ◽  
Age Related

Botanical compounds have been widely used throughout history as cures for various diseases and ailments. Many of these compounds exhibit strong antioxidative, anti-inflammatory, and antiapoptotic properties. These are also common damaging mechanisms apparent in several ocular diseases, including age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, cataract, and retinitis pigmentosa. In recent years, there have been many epidemiological and clinical studies that have demonstrated the beneficial effects of plant-derived compounds, such as curcumin, lutein and zeaxanthin, danshen, ginseng, and many more, on these ocular pathologies. Studies in cell cultures and animal models showed promising results for their uses in eye diseases. While there are many apparent significant correlations, further investigation is needed to uncover the mechanistic pathways of these botanical compounds in order to reach widespread pharmaceutical use and provide noninvasive alternatives for prevention and treatments of the major eye diseases.

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