The Time and Place of Fertilization of the Golden Hamster Egg

Development ◽  
1956 ◽  
Vol 4 (1) ◽  
pp. 42-56
Author(s):  
Fritz Strauss

There is little precise information in the literature as to the exact place where the union of the male and female gametes occurs in the genital tract of mammals. Yet it seems that an exact knowledge of the place of fertilization might be of great significance, not only for our understanding of the process of fertilization itself, but in its relation to the manifold problems associated with the limited span of time during which the capacity for fertilization persists in the sperm and egg, and to the physiology of later development and implantation. In most writings about the early development of Man and other mammals, it is assumed that the egg is fertilized in the cephalic part of the oviduct. However, there is still insufficient evidence to justify such general assumptions. It would not be surprising if it should be shown that different species have different topographical positions of the fertilization site correlated for instance with such factors as spontaneous versus induced ovulation.

Blood ◽  
1952 ◽  
Vol 7 (9) ◽  
pp. 948-949 ◽  
Author(s):  
KENNETH OTTIS ◽  
OSCAR E. TAUBER

Abstract Healthy, adult male and female golden hamsters, 3 months of age, showed blood platelet count means of 688,000 ± 141,000 per cu. mm. and 742,000 ± 120,000 per cu. mm., respectively, when direct counts were made with siliconized pipets and with Rees and Ecker fluid as a diluent.


1986 ◽  
Vol 20 (4) ◽  
pp. 379-389 ◽  
Author(s):  
Francien H. de Jonge ◽  
Bengt J. Meyerson ◽  
Nanne E. van de Poll

2014 ◽  
Vol 42 ◽  
pp. 17-24 ◽  
Author(s):  
Renee N. Sadowski ◽  
Pul Park ◽  
Steven L. Neese ◽  
Duncan C. Ferguson ◽  
Susan L. Schantz ◽  
...  

2021 ◽  
Author(s):  
Ajay Pradhan ◽  
Subrata Pramanik ◽  
Per-Erik Olsson

Abstract BackgroundThe classical concept of brain sex differentiation suggests that steroid hormones released from the gonads program male and female brains differently. However, several studies indicate that steroid hormones are not the only determinant of brain sex differentiation and that genetic differences could also be involved.MethodsIn this study, we have performed RNA sequencing of rat brains at embryonic days 12 (E12), E13, and E14. The aim was to identify differentially expressed genes between male and female rat brains during early development. ResultsAnalysis of genes expressed with the highest sex differences showed that Xist was highly expressed in females having XX genotype with an increasing ratio over time. Analysis of genes expressed with the highest male expression identified three main genes. At E12, two genes located in the azoospermia factor A (AZFa) region on the Y chromosome were highly expressed in males. These were Ddx3y (1552-fold higher in males) and Kdm6c (147-fold higher in males). The expression of Kdm6c, but not Ddx3y, remained high at both E13 and E14. In qRT-PCR analysis, these two genes were highly expressed in all the stages in male brain. In addition to these genes, one of the several copies of Sry in the rat genome, Sry4, showed a high expression in the male brains at all three time points. At all three time points several other genes were also found to show sex bias, but with lower differences in gene expression. ConclusionThe observed sex-specific expression of genes at early development suggests that the rat brain is sexually dimorphic prior to gonadal action on the brain and identifies the AZFa region genes as a possible contributor to male brain development.


Blood ◽  
1964 ◽  
Vol 23 (3) ◽  
pp. 375-388 ◽  
Author(s):  
JOSEPH D. SHERMAN ◽  
MARVIN M. ADNER ◽  
WILLIAM DAMESHEK

Abstract Thymectomy in our hamster colony produced two major changes: (1) wasting disease, and (2) impaired immune response. Wasting occurred in 36 per cent of all males of all ages and was noted even when thymectomy was performed at 4 weeks of age. Lymphoid atrophy was profound and lymphocytopenia sustained. In the non-wasted hamster, the lymphoid atrophy was less striking and there was only transient lymphocytopenia. Experiments in this study were limited to the non-wasted animals. An impaired immune response was demonstrated in both humoral antibody production and in delayed hypersensitivity (heterograft rejection). Male and female hamsters thymectomized at 2 weeks showed an impaired ability to make antibodies against HGG and exhibited prolonged survival of mouse (AJAX) skin. In animals thymectomized at 4 to 8 weeks of age, impaired humoral antibody production could not be demonstrated. Antigen administered on the day of thymectomy was not associated with impaired humoral antibody production. Splenectomy appeared to be more effective than thymectomy in the adult (8-week) hamster in inhibiting humoral antibody production. From these studies, it is evident that the thymectomized, non-wasted male and female hamster has an impaired immune mechanism for both humoral antibody production and heterologous skin rejection.


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