scholarly journals A new family of transcription factors

Development ◽  
2008 ◽  
Vol 135 (18) ◽  
pp. 3093-3101 ◽  
Author(s):  
Y. Yamada ◽  
H. Y. Wang ◽  
M. Fukuzawa ◽  
G. J. Barton ◽  
J. G. Williams
Keyword(s):  
Transcription Factors ◽  
New Family

A new family of plant transcription factors displays a novel ssDNA-binding surface

2002 ◽  
Vol 9 (7) ◽  
pp. 512-517 ◽  
Author(s):  
Darrell Desveaux ◽  
Julie Allard ◽  
Normand Brisson ◽  
Jurgen Sygusch
Keyword(s):  
Transcription Factors ◽  
Ssdna Binding ◽  
New Family ◽  
Binding Surface

scholarly journals LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins

2007 ◽  
Vol 35 (19) ◽  
pp. 6663-6671 ◽  
Author(s):  
Aman Husbands ◽  
Elizabeth M. Bell ◽  
Bin Shuai ◽  
Harley M.S. Smith ◽  
Patricia S. Springer
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
New Family ◽  
Lateral Organ ◽  
Bhlh Proteins ◽  
Organ Boundaries

scholarly journals A Novel DNA-Binding Motif, Hallmark of a New Family of Plant Transcription Factors

2005 ◽  
Vol 137 (2) ◽  
pp. 602-606 ◽  
Author(s):  
José L. Carrasco ◽  
Gema Ancillo ◽  
María José Castelló ◽  
Pablo Vera
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Binding Motif ◽  
New Family

scholarly journals Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells

Blood ◽  
1993 ◽  
Vol 81 (11) ◽  
pp. 2854-2859 ◽  
Author(s):  
R Hromas ◽  
J Moore ◽  
T Johnston ◽  
C Socha ◽  
M Klemsz
Keyword(s):  
Polymerase Chain Reaction ◽  
Transcription Factors ◽  
Pcr Amplification ◽  
Amino Acid Sequences ◽  
Myelogenous Leukemia ◽  
Transcriptional Activators ◽  
Chain Reaction ◽  
New Family ◽  
Polymerase Chain ◽  
Forkhead Gene

Abstract The forkhead gene (FKH) regulates morphogenesis in Drosophila. It is the prototype of a new family of transcriptional activators. Partially degenerate oligonucleotides to two conserved amino acid sequences of this family were used to prime a polymerase chain reaction (PCR) amplification of HEL cell cDNA. Two unique clones, designated H3 and H8, were isolated that contained homologies to FKH. A third novel clone, 5–3, was isolated by low stringency screening of a chronic myelogenous leukemia cDNA library using H8 as a probe. H3 and 5–3 are preferentially expressed in restricted hematopoietic lineages, while the expression of H8 was ubiquitous. Southern analysis showed that FKH 5–3 is conserved through yeast, which is rare among tissue-specific transcription factors. The H3 and 5–3 clones provide evidence that FKH family members are present in a tissue-restricted manner in humans.

scholarly journals Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells

Blood ◽  
1993 ◽  
Vol 81 (11) ◽  
pp. 2854-2859 ◽  
Author(s):  
R Hromas ◽  
J Moore ◽  
T Johnston ◽  
C Socha ◽  
M Klemsz
Keyword(s):  
Polymerase Chain Reaction ◽  
Transcription Factors ◽  
Pcr Amplification ◽  
Amino Acid Sequences ◽  
Myelogenous Leukemia ◽  
Transcriptional Activators ◽  
Chain Reaction ◽  
New Family ◽  
Polymerase Chain ◽  
Forkhead Gene

The forkhead gene (FKH) regulates morphogenesis in Drosophila. It is the prototype of a new family of transcriptional activators. Partially degenerate oligonucleotides to two conserved amino acid sequences of this family were used to prime a polymerase chain reaction (PCR) amplification of HEL cell cDNA. Two unique clones, designated H3 and H8, were isolated that contained homologies to FKH. A third novel clone, 5–3, was isolated by low stringency screening of a chronic myelogenous leukemia cDNA library using H8 as a probe. H3 and 5–3 are preferentially expressed in restricted hematopoietic lineages, while the expression of H8 was ubiquitous. Southern analysis showed that FKH 5–3 is conserved through yeast, which is rare among tissue-specific transcription factors. The H3 and 5–3 clones provide evidence that FKH family members are present in a tissue-restricted manner in humans.

HIPK2: a multitalented partner for transcription factors in DNA damage response and developmentThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

2007 ◽  
Vol 85 (4) ◽  
pp. 411-418 ◽  
Author(s):  
Cinzia Rinaldo ◽  
Andrea Prodosmo ◽  
Francesca Siepi ◽  
Silvia Soddu
Keyword(s):  
Transcription Factors ◽  
Gene Transcription ◽  
Review Process ◽  
Peer Review Process ◽  
Post Translational Modification ◽  
Interacting Protein ◽  
Cellular Processes ◽  
New Family ◽  
Damage Response ◽  
Selection Of

Protein phosphorylation is a widely diffuse and versatile post-translational modification that controls many cellular processes, from signal transduction to gene transcription. The homeodomain-interacting protein kinases (HIPKs) belong to a new family of serine–threonine kinases first identified as corepressors for homeodomain transcription factors. Different screenings for the identification of new partners of transcription factors have indicated that HIPK2, the best characterized member of the HIPK family, is a multitalented coregulator of an increasing number of transcription factors and cofactors. The aim of this review is to describe the different mechanisms through which HIPK2 regulates gene transcription.

Microstructure and crystal symmetry of Pb2Sr2(Y/Ca)Cu3O9−δ

1990 ◽  
Vol 48 (4) ◽  
pp. 64-65
Author(s):  
Y. P. Lin ◽  
J. S. Xue ◽  
J. E. Greedan
Keyword(s):  
Electron Diffraction ◽  
High Temperature Superconductors ◽  
Carbon Film ◽  
Basic Structure ◽  
Crystal Symmetry ◽  
X Ray Diffraction ◽  
X Ray ◽  
Space Groups ◽  
New Family ◽  
Convergent Beam

A new family of high temperature superconductors based on Pb2Sr2YCu3O9−δ has recently been reported. One method of improving Tc has been to replace Y partially with Ca. Although the basic structure of this type of superconductors is known, the detailed structure is still unclear, and various space groups has been proposed. In our work, crystals of Pb2Sr2YCu3O9−δ with dimensions up to 1 × 1 × 0.25.mm and with Tc of 84 K have been grown and their superconducting properties described. The defects and crystal symmetry have been investigated using electron microscopy performed on crushed crystals supported on a holey carbon film.Electron diffraction confirmed x-ray diffraction results which showed that the crystals are primitive orthorhombic with a=0.5383, b=0.5423 and c=1.5765 nm. Convergent Beam Electron Diffraction (CBED) patterns for the and axes are shown in Figs. 1 and 2 respectively.

A new family of fluorescent calcium indicators designed to resist leakage or for measuring calcium near membranes

1994 ◽  
Vol 52 ◽  
pp. 168-169
Author(s):  
Martin Poenie ◽  
Akwasi Minta ◽  
Charles Vorndran
Keyword(s):  
Metal Binding ◽  
Acetoxymethyl Ester ◽  
Binding Properties ◽  
Fura 2 ◽  
New Family ◽  
Anion Transporter ◽  
Calcium Indicator ◽  
Calcium Indicators ◽  
High Calcium ◽  
Intracellular Compartmentalization

The use of fura-2 as an intracellular calcium indicator is complicated by problems of rapid dye leakage and intracellular compartmentalization which is due to a probenecid sensitive anion transporter. In addition there is increasing evidence for localized microdomains of high calcium signals which may not be faithfully reported by fura-2.We have developed a new family of fura-2 analogs aimed at addressing some of these problems. These new indicators are based on a modified bapta which can be readily derivatized to produce fura-2 analogs with a variety of new properties. The modifications do not affect the chromophore and have little impact on the spectral and metal binding properties of the indicator. One of these new derivatives known as FPE3 is a zwitterionic analog of fura-2 that can be loaded into cells as an acetoxymethyl ester and whose retention in cells is much improved. The improved retention of FPE3 is important for both cuvettebased measurements of cell suspensions and for calcium imaging.

Scanning tunneling microscopy and atomic force microscopy: New tools for biology

1989 ◽  
Vol 47 ◽  
pp. 778-779
Author(s):  
CE Bracker ◽  
P. K. Hansma
Keyword(s):  
Physical Property ◽  
Scanning Probe ◽  
Scanning Tunneling ◽  
Small Scale ◽  
Tunneling Microscopy ◽  
Force Microscopy ◽  
New Family ◽  
Small Probe ◽  
Atomic Force ◽  
Transmission Electron

A new family of scanning probe microscopes has emerged that is opening new horizons for investigating the fine structure of matter. The earliest and best known of these instruments is the scanning tunneling microscope (STM). First published in 1982, the STM earned the 1986 Nobel Prize in Physics for two of its inventors, G. Binnig and H. Rohrer. They shared the prize with E. Ruska for his work that had led to the development of the transmission electron microscope half a century earlier. It seems appropriate that the award embodied this particular blend of the old and the new because it demonstrated to the world a long overdue respect for the enormous contributions electron microscopy has made to the understanding of matter, and at the same time it signalled the dawn of a new age in microscopy. What we are seeing is a revolution in microscopy and a redefinition of the concept of a microscope.Several kinds of scanning probe microscopes now exist, and the number is increasing. What they share in common is a small probe that is scanned over the surface of a specimen and measures a physical property on a very small scale, at or near the surface. Scanning probes can measure temperature, magnetic fields, tunneling currents, voltage, force, and ion currents, among others.

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